A4J7F3 (DNAK_DESRM) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Chaperone protein DnaK

Alternative name(s):
HSP70
Heat shock 70 kDa protein
Heat shock protein 70

Gene names

Name:	dnaK
Ordered Locus Names:	Dred_2496

Organism

Desulfotomaculum reducens (strain MI-1) [Complete proteome] [HAMAP]

Taxonomic identifier

349161 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Peptococcaceae › Desulfotomaculum

Protein attributes

Sequence length	615 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Acts as a chaperone By similarity. HAMAP MF_00332
Induction	By stress conditions e.g. heat shock By similarity. HAMAP MF_00332
Sequence similarities	Belongs to the heat shock protein 70 family.

Ontologies

Keywords
Biological process	Stress response
Ligand	ATP-binding Nucleotide-binding
Molecular function	Chaperone
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	protein folding Inferred from electronic annotation. Source: InterPro response to stress Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW unfolded protein binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 615	615	Chaperone protein DnaK HAMAP MF_00332		PRO_1000072035
Amino acid modifications
	Modified residue	174	1	Phosphothreonine; by autocatalysis By similarity

Sequences

	Sequence		Length	Mass (Da)
	A4J7F3 [UniParc]. Last modified May 1, 2007. Version 1. Checksum: D067A1407B322DBA	FASTA	615	65,530
	10 20 30 40 50 60 MGKVIGIDLG TTNSCVAVME GGEAVVIPNA EGARTTPSVV GFSKTGERLV GQVAKRQAVS 70 80 90 100 110 120 NPDRTIQSIK RYMGTNHKVS IDGKDYSPQE ISAMILSKLK ADAEAYLGES VTQAVITVPA 130 140 150 160 170 180 YFSDAQRQAT KDAGKIAGLE VLRIINEPTA AALAYGLDKE GDQTIQVFDL GGGTFDVSIL 190 200 210 220 230 240 ELGDGVFEVK STSGNNRLGG DDFDQRIVDF LVAEFKKETG VDLSKDKMAM QRLKESAEKA 250 260 270 280 290 300 KIELSGVLST NVNLPFISVG ADGPLHLDVN ISRAKFDELT ADLVEKTMGP TRQALADSGL 310 320 330 340 350 360 ETNEINKVLM VGGSTRIPAV QEAVRKFLGK EPHKGINPDE CVALGAAIQA GVLAGEVKDV 370 380 390 400 410 420 LLLDVTPLSL GIETLGGVFT KLIDRNTTIP TSKSQIFSTA ADNQPSVEIH VLQGERQMAA 430 440 450 460 470 480 DNKTLGRFQL SGIPPAPRGV PQIEVKFDID VNGIVSVSAK DMGTGTVQSI SITGGTGGLS 490 500 510 520 530 540 DDEINRMVNE AEKFAEEDKK RKEAVEVKNQ ADSLIYQAEK TIKDLGENAD KAKVEAVQKA 550 560 570 580 590 600 VEELRTAMNG NDTDLIKNKL EELTKPLHEL TADLYQQQQA QQAAAQGGCA GGNCGGQAEK 610 DNVVDADYEV KDDNK

References

[1]

"Complete sequence of Desulfotomaculum reducens MI-1." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Sims D., Brettin T., Bruce D., Han C., Tapia R., Schmutz J., Larimer F. , Land M., Hauser L., Kyrpides N., Kim E., Tebo B.M., Richardson P. Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MI-1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000612 Genomic DNA. Translation: ABO51006.1.
RefSeq	YP_001113831.1. NC_009253.1.
3D structure databases
ProteinModelPortal	A4J7F3.
SMR	A4J7F3. Positions 1-507.
ModBase	Search...
Protein-protein interaction databases
STRING	A4J7F3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4957787.
GenomeReviews	Gene locus Dred_2496 in contig CP000612_GR.
KEGG	drm:Dred_2496.
PATRIC	21731347. VBIDesRed82656_2730.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0443.
HOGENOM	HBG334976.
OMA	PDRSVNP.
PhylomeDB	A4J7F3.
ProtClustDB	PRK00290.
Enzyme and pathway databases
BioCyc	DRED349161:DRED_2496-MONOMER.
Family and domain databases
HAMAP	MF_00332. DnaK. [Tree]
InterPro	IPR012725. Chaperone_DnaK. IPR018181. Heat_shock_70_CS. IPR001023. Hsp70. IPR013126. Hsp_70. [Graphical view]
KO	K04043.
PANTHER	PTHR19375. Hsp70. 1 hit.
Pfam	PF00012. HSP70. 1 hit. [Graphical view]
PRINTS	PR00301. HEATSHOCK70.
TIGRFAMs	TIGR02350. Prok_dnaK. 1 hit.
PROSITE	PS00297. HSP70_1. 1 hit. PS00329. HSP70_2. 1 hit. PS01036. HSP70_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DNAK_DESRM

Accession

Primary (citable) accession number: A4J7F3

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	May 1, 2007
Last modified:	January 25, 2012
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program