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Protein

Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha

Gene

accA

Organism
Desulfotomaculum reducens (strain MI-1)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO2 group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.UniRule annotationSAAS annotation

Catalytic activityi

ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA.UniRule annotationSAAS annotation

Pathwayi: malonyl-CoA biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes malonyl-CoA from acetyl-CoA.UniRule annotationSAAS annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha (accA), Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta (accD)
This subpathway is part of the pathway malonyl-CoA biosynthesis, which is itself part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes malonyl-CoA from acetyl-CoA, the pathway malonyl-CoA biosynthesis and in Lipid metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationSAAS annotation, TransferaseImported
Biological processFatty acid biosynthesisUniRule annotationSAAS annotation, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00655; UER00711.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alphaUniRule annotationSAAS annotation (EC:6.4.1.2UniRule annotationSAAS annotation)
Short name:
ACCase subunit alphaUniRule annotation
Short name:
Acetyl-CoA carboxylase carboxyltransferase subunit alphaUniRule annotation
Gene namesi
Name:accAUniRule annotation
Ordered Locus Names:Dred_2314Imported
OrganismiDesulfotomaculum reducens (strain MI-1)Imported
Taxonomic identifieri349161 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptococcaceaeDesulfotomaculum
Proteomesi
  • UP000001556 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).UniRule annotationSAAS annotation

Protein-protein interaction databases

STRINGi349161.Dred_2314.

Structurei

3D structure databases

ProteinModelPortaliA4J6X1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 290CoA carboxyltransferase C-terminalInterPro annotationAdd BLAST255

Sequence similaritiesi

Belongs to the AccA family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4108FRU. Bacteria.
COG0825. LUCA.
HOGENOMiHOG000273832.
KOiK01962.
OMAiCSSILWR.
OrthoDBiPOG091H0647.

Family and domain databases

HAMAPiMF_00823. AcetylCoA_CT_alpha. 1 hit.
InterProiView protein in InterPro
IPR001095. Acetyl_CoA_COase_a_su.
IPR029045. ClpP/crotonase-like_dom.
IPR011763. COA_CT_C.
PANTHERiPTHR42853. PTHR42853. 1 hit.
PfamiView protein in Pfam
PF03255. ACCA. 1 hit.
PRINTSiPR01069. ACCCTRFRASEA.
SUPFAMiSSF52096. SSF52096. 1 hit.
TIGRFAMsiTIGR00513. accA. 1 hit.
PROSITEiView protein in PROSITE
PS50989. COA_CT_CTER. 1 hit.

Sequencei

Sequence statusi: Complete.

A4J6X1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALDFERPIL ELEAKIEELK RFTNEKGIDF SEEIILLEKK SRDMKEKIYS
60 70 80 90 100
NLNPWQKVQI ARHSARPNAL DYINALFSDF LEMHGDRLYG DDPAVIGGIS
110 120 130 140 150
WYKGIPVTVI GHLKGHDTKE NVERNFGMAH PEGFRKALRL MKQAEKFNRP
160 170 180 190 200
VICFVDTSGA YPGMGAEERG QGEAIAKNLM AMSALKIPVI SIVIGEGGSG
210 220 230 240 250
GALALGVANK ILMQEHAIFS VSSPEAAASI LWKDGTKAKE AAQALNLTAQ
260 270 280 290 300
DLLRLGVIDE IVSEPLGGAH NDLPKAYGLI DESLERNLKA ILERDPAELV
310
ESRYAKFRAM GQTG
Length:314
Mass (Da):34,557
Last modified:May 1, 2007 - v1
Checksum:i01859A6A9024CF6C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000612 Genomic DNA. Translation: ABO50824.1.
RefSeqiWP_011878622.1. NC_009253.1.

Genome annotation databases

EnsemblBacteriaiABO50824; ABO50824; Dred_2314.
KEGGidrm:Dred_2314.

Similar proteinsi

Entry informationi

Entry nameiA4J6X1_DESRM
AccessioniPrimary (citable) accession number: A4J6X1
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2007
Last sequence update: May 1, 2007
Last modified: September 27, 2017
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported