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Protein

Porphobilinogen deaminase

Gene

hemC

Organism
Desulfotomaculum reducens (strain MI-1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.UniRule annotation

Miscellaneous

The porphobilinogen subunits are added to the dipyrromethane group.UniRule annotation

Catalytic activityi

4 porphobilinogen + H2O = hydroxymethylbilane + 4 NH3.UniRule annotation

Cofactori

dipyrromethaneUniRule annotationNote: Binds 1 dipyrromethane group covalently.UniRule annotation

Pathwayi: protoporphyrin-IX biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes coproporphyrinogen-III from 5-aminolevulinate.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Porphobilinogen deaminase (hemC)
  3. no protein annotated in this organism
  4. no protein annotated in this organism
This subpathway is part of the pathway protoporphyrin-IX biosynthesis, which is itself part of Porphyrin-containing compound metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes coproporphyrinogen-III from 5-aminolevulinate, the pathway protoporphyrin-IX biosynthesis and in Porphyrin-containing compound metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processPorphyrin biosynthesis

Enzyme and pathway databases

BioCyciDRED349161:G1G8H-2337-MONOMER
UniPathwayiUPA00251; UER00319

Names & Taxonomyi

Protein namesi
Recommended name:
Porphobilinogen deaminaseUniRule annotation (EC:2.5.1.61UniRule annotation)
Short name:
PBGUniRule annotation
Alternative name(s):
Hydroxymethylbilane synthaseUniRule annotation
Short name:
HMBSUniRule annotation
Pre-uroporphyrinogen synthaseUniRule annotation
Gene namesi
Name:hemCUniRule annotation
Ordered Locus Names:Dred_2163
OrganismiDesulfotomaculum reducens (strain MI-1)
Taxonomic identifieri349161 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptococcaceaeDesulfotomaculum
Proteomesi
  • UP000001556 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000786081 – 309Porphobilinogen deaminaseAdd BLAST309

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei241S-(dipyrrolylmethanemethyl)cysteineUniRule annotation1

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi349161.Dred_2163

Structurei

3D structure databases

ProteinModelPortaliA4J6H7
SMRiA4J6H7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HMBS family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D6W Bacteria
COG0181 LUCA
HOGENOMiHOG000228587
KOiK01749
OMAiCQVPIGV
OrthoDBiPOG091H064B

Family and domain databases

Gene3Di3.30.160.40, 1 hit
HAMAPiMF_00260 Porphobil_deam, 1 hit
InterProiView protein in InterPro
IPR000860 HemC
IPR022419 Porphobilin_deaminase_cofac_BS
IPR022417 Porphobilin_deaminase_N
IPR022418 Porphobilinogen_deaminase_C
IPR036803 Porphobilinogen_deaminase_C_sf
PANTHERiPTHR11557 PTHR11557, 1 hit
PfamiView protein in Pfam
PF01379 Porphobil_deam, 1 hit
PF03900 Porphobil_deamC, 1 hit
PIRSFiPIRSF001438 4pyrrol_synth_OHMeBilane_synth, 1 hit
PRINTSiPR00151 PORPHBDMNASE
SUPFAMiSSF54782 SSF54782, 1 hit
TIGRFAMsiTIGR00212 hemC, 1 hit
PROSITEiView protein in PROSITE
PS00533 PORPHOBILINOGEN_DEAM, 1 hit

Sequencei

Sequence statusi: Complete.

A4J6H7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKHKITVGSR DSALALWQTR WVVEQLEKQN PDVTFEITTM KTKGDKMLDV
60 70 80 90 100
ALAKIGDKGL FTKELEVAML QKEIDFAVHS LKDMPTALPE GLIIGAVCKR
110 120 130 140 150
DNPGDALISK DGRKLDELPK GARIGTSSLR RCAQLLNYRP DFQLEALRGN
160 170 180 190 200
LNTRMKKLVS EQLDGIILAA AGITRMGWED MIAEIIPFQV CLPAVGQGAI
210 220 230 240 250
SVECREDDPE ILNLLKGIEH TETKAATEAE RSLLRYLEGG CQVPIGAHSE
260 270 280 290 300
VKNNRLMLTA VVATLDGTKV IRAQGENEVN KAVELGIEVA EKLMAMGGKK

ILEEVRAGE
Length:309
Mass (Da):33,894
Last modified:May 1, 2007 - v1
Checksum:i6AC721C7C4D99181
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000612 Genomic DNA Translation: ABO50680.1
RefSeqiWP_011878482.1, NC_009253.1

Genome annotation databases

EnsemblBacteriaiABO50680; ABO50680; Dred_2163
KEGGidrm:Dred_2163

Similar proteinsi

Entry informationi

Entry nameiHEM3_DESRM
AccessioniPrimary (citable) accession number: A4J6H7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 1, 2007
Last modified: May 23, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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