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A4J5W6

- PNP_DESRM

UniProt

A4J5W6 - PNP_DESRM

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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Desulfotomaculum reducens (strain MI-1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi496 – 4961MagnesiumUniRule annotation
Metal bindingi502 – 5021MagnesiumUniRule annotation

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
  4. RNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. mRNA catabolic process Source: UniProtKB-HAMAP
  2. RNA processing Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciDRED349161:GHP6-2005-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:Dred_1950
OrganismiDesulfotomaculum reducens (strain MI-1)
Taxonomic identifieri349161 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptococcaceaeDesulfotomaculum
ProteomesiUP000001556: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 740740Polyribonucleotide nucleotidyltransferasePRO_0000329624Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi349161.Dred_1950.

Structurei

3D structure databases

ProteinModelPortaliA4J5W6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini563 – 62260KHUniRule annotationAdd
BLAST
Domaini632 – 70675S1 motifUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
Contains 1 KH domain.UniRule annotation
Contains 1 S1 motif domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218326.
KOiK00962.
OMAiRRIITHD.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4J5W6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSENQVLIRE ISLGGRTLTL ETGRMAKQAS GAVLVTYGET VVLVTATVAK
60 70 80 90 100
NTRDIDFFPL TVDYEERLYA VGKIPGGFIK REGRPSEKAI LSGRLIDRPI
110 120 130 140 150
RPLFPKHMRN EVQVVATVMS VDQDNAPEIA AMIGASAALH ISKIPLKKPI
160 170 180 190 200
GGVIVGRVDG QFVINPMVRQ AENSDMHLVV AGTDDAVMMV EAGAKEVPES
210 220 230 240 250
EMLEGIMYGH EKVKEIVKFI EDFRTEALGM GLAFEKMEIP EPQFDSNMSE
260 270 280 290 300
AILTIAEEAI REAVLHCSRE KLTKKQREVY MDEVMSGLQE KFLEQFPENP
310 320 330 340 350
KEVTMLIEKA EKKVVRRIIT HDKLRIDGRA IDEIRPISVE VGVLPRTHGT
360 370 380 390 400
GLFTRGQTQI LSVATLGSIS EEQILDGLGV EESKRYMHHY NFPPFSTGET
410 420 430 440 450
KPMRSPGRRE IGHGALAERA LEPMIPPEEV FPYTIRVVSE AIESNGSTSM
460 470 480 490 500
GSVCGSTLSL MDAGVPLKAP VAGVAMGLIM EEDQFTVLTD IQGLEDHLGD
510 520 530 540 550
MDFKVAGSAN GVTALQMDIK IPGITREVFE QALEQAHRGR MFILGKMLEV
560 570 580 590 600
LSTPRAEISV HAPAIIRTSI HPDKIRDIIG PGGKIIKKLV EETGADIDIE
610 620 630 640 650
DDGRVFIAAV DREKGKRALE IIQSITAEVQ VGKLYNGKVT RVTDFGCFVE
660 670 680 690 700
VIPGVMGLPG KEGLVHISQL AFQRVEKTED IVKEGEVIAV KAIGYDQQGR
710 720 730 740
LKLSKKEAMR DMGLAPAEST SEQPEKRERR PFSRPKATKE
Length:740
Mass (Da):81,425
Last modified:May 1, 2007 - v1
Checksum:iDB1993E12F953C1C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000612 Genomic DNA. Translation: ABO50469.1.
RefSeqiYP_001113294.1. NC_009253.1.

Genome annotation databases

EnsemblBacteriaiABO50469; ABO50469; Dred_1950.
GeneIDi4955875.
KEGGidrm:Dred_1950.
PATRICi21730135. VBIDesRed82656_2140.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000612 Genomic DNA. Translation: ABO50469.1 .
RefSeqi YP_001113294.1. NC_009253.1.

3D structure databases

ProteinModelPortali A4J5W6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 349161.Dred_1950.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABO50469 ; ABO50469 ; Dred_1950 .
GeneIDi 4955875.
KEGGi drm:Dred_1950.
PATRICi 21730135. VBIDesRed82656_2140.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218326.
KOi K00962.
OMAi RRIITHD.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci DRED349161:GHP6-2005-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MI-1.

Entry informationi

Entry nameiPNP_DESRM
AccessioniPrimary (citable) accession number: A4J5W6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: May 1, 2007
Last modified: November 26, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3