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A4J5V7

- A4J5V7_DESRM

UniProt

A4J5V7 - A4J5V7_DESRM

Protein

Aspartate-semialdehyde dehydrogenase

Gene

asd

Organism
Desulfotomaculum reducens (strain MI-1)
Status
Unreviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (01 May 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.UniRule annotation

    Catalytic activityi

    L-aspartate 4-semialdehyde + phosphate + NADP+ = L-4-aspartyl phosphate + NADPH.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei99 – 991PhosphateUniRule annotation
    Active sitei128 – 1281Acyl-thioester intermediateUniRule annotation
    Binding sitei155 – 1551SubstrateUniRule annotation
    Binding sitei234 – 2341SubstrateUniRule annotation
    Active sitei241 – 2411Proton acceptorUniRule annotation
    Binding sitei314 – 3141NADPUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi12 – 154NADPUniRule annotation
    Nucleotide bindingi40 – 412NADPUniRule annotation
    Nucleotide bindingi158 – 1592NADPUniRule annotation

    GO - Molecular functioni

    1. aspartate-semialdehyde dehydrogenase activity Source: UniProtKB-HAMAP
    2. N-acetyl-gamma-glutamyl-phosphate reductase activity Source: InterPro
    3. NAD binding Source: InterPro
    4. NADP binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' L-methionine biosynthetic process Source: UniProtKB-HAMAP
    2. diaminopimelate biosynthetic process Source: UniProtKB-HAMAP
    3. isoleucine biosynthetic process Source: InterPro
    4. lysine biosynthetic process via diaminopimelate Source: UniProtKB-HAMAP
    5. threonine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotationImported

    Keywords - Biological processi

    Amino-acid biosynthesis, Diaminopimelate biosynthesisUniRule annotation, Lysine biosynthesisUniRule annotation, Methionine biosynthesisUniRule annotation, Threonine biosynthesisUniRule annotation

    Keywords - Ligandi

    NADPUniRule annotation

    Enzyme and pathway databases

    BioCyciDRED349161:GHP6-1996-MONOMER.
    UniPathwayiUPA00034; UER00016.
    UPA00050; UER00463.
    UPA00051; UER00464.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aspartate-semialdehyde dehydrogenaseUniRule annotation (EC:1.2.1.11UniRule annotation)
    Short name:
    ASA dehydrogenaseUniRule annotation
    Short name:
    ASADHUniRule annotation
    Alternative name(s):
    Aspartate-beta-semialdehyde dehydrogenaseUniRule annotation
    Gene namesi
    Name:asdUniRule annotation
    Ordered Locus Names:Dred_1941Imported
    OrganismiDesulfotomaculum reducens (strain MI-1)Imported
    Taxonomic identifieri349161 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptococcaceaeDesulfotomaculum
    ProteomesiUP000001556: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: InterPro

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi349161.Dred_1941.

    Structurei

    3D structure databases

    ProteinModelPortaliA4J5V7.
    SMRiA4J5V7. Positions 5-331.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the aspartate-semialdehyde dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0136.
    HOGENOMiHOG000013357.
    KOiK00133.
    OMAiANKGCIV.
    OrthoDBiEOG6JB158.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_02121. ASADH.
    InterProiIPR012080. Asp_semialdehyde_DH.
    IPR005986. Asp_semialdehyde_DH_beta.
    IPR016040. NAD(P)-bd_dom.
    IPR000534. Semialdehyde_DH_NAD-bd.
    IPR012280. Semialdhyde_DH_dimer_dom.
    [Graphical view]
    PfamiPF01118. Semialdhyde_dh. 1 hit.
    PF02774. Semialdhyde_dhC. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000148. ASA_dh. 1 hit.
    SMARTiSM00859. Semialdhyde_dh. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR01296. asd_B. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A4J5V7-1 [UniParc]FASTAAdd to Basket

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    MNTVNLVIVG ATGAVGKEIL NILKERNFPI NKLRLCATSR SAGTEIEFQG    50
    HKYLVEETTP DSFNGMDVAL FAGGKASLEF GKAAVERGCV VIDNSSNYRM 100
    DPEVPLVVPE VNPEDVKKHK GIIANPNCST IIMVVALKPL HDAAGIKRVV 150
    VSTYQAVSGA GKEGIEELTE QVKATLDGRE YPPNKFAHQI AFNLIPHIDV 200
    FQEMDYTKEE WKMVKETQKI MHDDNIKITA TTVRVPIYRS HSESINIETE 250
    EKITADQARE ILANAPGIIV QDDVTNKVYP MPLFTSDRDE VFVGRIREDN 300
    TIDKGLNLWV VGDQIRKGAA TNAVQIAELV LKYDSLMKKE 340
    Length:340
    Mass (Da):37,691
    Last modified:May 1, 2007 - v1
    Checksum:iC54DCB13E948F775
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000612 Genomic DNA. Translation: ABO50460.1.
    RefSeqiYP_001113285.1. NC_009253.1.

    Genome annotation databases

    EnsemblBacteriaiABO50460; ABO50460; Dred_1941.
    GeneIDi4956285.
    KEGGidrm:Dred_1941.
    PATRICi21730117. VBIDesRed82656_2131.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000612 Genomic DNA. Translation: ABO50460.1 .
    RefSeqi YP_001113285.1. NC_009253.1.

    3D structure databases

    ProteinModelPortali A4J5V7.
    SMRi A4J5V7. Positions 5-331.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 349161.Dred_1941.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABO50460 ; ABO50460 ; Dred_1941 .
    GeneIDi 4956285.
    KEGGi drm:Dred_1941.
    PATRICi 21730117. VBIDesRed82656_2131.

    Phylogenomic databases

    eggNOGi COG0136.
    HOGENOMi HOG000013357.
    KOi K00133.
    OMAi ANKGCIV.
    OrthoDBi EOG6JB158.

    Enzyme and pathway databases

    UniPathwayi UPA00034 ; UER00016 .
    UPA00050 ; UER00463 .
    UPA00051 ; UER00464 .
    BioCyci DRED349161:GHP6-1996-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_02121. ASADH.
    InterProi IPR012080. Asp_semialdehyde_DH.
    IPR005986. Asp_semialdehyde_DH_beta.
    IPR016040. NAD(P)-bd_dom.
    IPR000534. Semialdehyde_DH_NAD-bd.
    IPR012280. Semialdhyde_DH_dimer_dom.
    [Graphical view ]
    Pfami PF01118. Semialdhyde_dh. 1 hit.
    PF02774. Semialdhyde_dhC. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000148. ASA_dh. 1 hit.
    SMARTi SM00859. Semialdhyde_dh. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR01296. asd_B. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MI-1Imported.

    Entry informationi

    Entry nameiA4J5V7_DESRM
    AccessioniPrimary (citable) accession number: A4J5V7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 1, 2007
    Last sequence update: May 1, 2007
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3