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A4J2F9

- GCSPB_DESRM

UniProt

A4J2F9 - GCSPB_DESRM

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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 2

Gene

gcvPB

Organism
Desulfotomaculum reducens (strain MI-1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciDRED349161:GHP6-766-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 2UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 2UniRule annotation
Glycine decarboxylase subunit 2UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 2UniRule annotation
Gene namesi
Name:gcvPBUniRule annotation
Ordered Locus Names:Dred_0723
OrganismiDesulfotomaculum reducens (strain MI-1)
Taxonomic identifieri349161 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptococcaceaeDesulfotomaculum
ProteomesiUP000001556: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 484484Probable glycine dehydrogenase (decarboxylating) subunit 2PRO_1000072771Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei270 – 2701N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

STRINGi349161.Dred_0723.

Structurei

3D structure databases

ProteinModelPortaliA4J2F9.
SMRiA4J2F9. Positions 4-482.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. C-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239368.
KOiK00283.
OMAiWTGLMMI.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00713. GcvPB.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

A4J2F9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTEKLIFELG SPGRQGVLFP ANDVPEIPPH ELLPRDLIRE QEVPLPEVSE
60 70 80 90 100
GDAVRHFVRL SRMNFGVDVG FYPLGSCTMK YNPKVAEDAA GLSGFANIHP
110 120 130 140 150
YQPDEISQGA LQLMYETQQD LAEITGMDAF TLQPAAGAQG ELTGMLIIKA
160 170 180 190 200
YLESKGETGR NKVIVPDSAH GTNPATAALC GFKVVEVKSD QRGGVDLAAL
210 220 230 240 250
KQLLGPDVAA LMLTNPSTLG LFEDNITEIA ALVHQAGGLL YYDGANLNAI
260 270 280 290 300
MGYARPGDMG FDVVHLNLHK TFGTPHGGGG PGSGPVGVKA ELAPFLPKPV
310 320 330 340 350
IIQREGNYLP DYHRPQSIGR VKAFFANFSV IVKAYTYLRS LGGKGLKEVS
360 370 380 390 400
EHAVLNANYL MKQLSDHFRV PYQRTCMHEF VVSPPEDMKE QGIKTLDIAK
410 420 430 440 450
RLLDYGYHPP TVYFPLIVEE ALMFEPTETE SKETLDEFAH NLIKVLAEAR
460 470 480
ENPDKLRNAP YTTPIRRLDE VMAARKPLVG WFPE
Length:484
Mass (Da):53,106
Last modified:May 1, 2007 - v1
Checksum:iDF3EA3E9F8930C33
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000612 Genomic DNA. Translation: ABO49262.1.
RefSeqiWP_011877098.1. NC_009253.1.
YP_001112087.1. NC_009253.1.

Genome annotation databases

EnsemblBacteriaiABO49262; ABO49262; Dred_0723.
GeneIDi4957321.
KEGGidrm:Dred_0723.
PATRICi21727429. VBIDesRed82656_0802.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000612 Genomic DNA. Translation: ABO49262.1 .
RefSeqi WP_011877098.1. NC_009253.1.
YP_001112087.1. NC_009253.1.

3D structure databases

ProteinModelPortali A4J2F9.
SMRi A4J2F9. Positions 4-482.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 349161.Dred_0723.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABO49262 ; ABO49262 ; Dred_0723 .
GeneIDi 4957321.
KEGGi drm:Dred_0723.
PATRICi 21727429. VBIDesRed82656_0802.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239368.
KOi K00283.
OMAi WTGLMMI.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci DRED349161:GHP6-766-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00713. GcvPB.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MI-1.

Entry informationi

Entry nameiGCSPB_DESRM
AccessioniPrimary (citable) accession number: A4J2F9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: May 1, 2007
Last modified: November 26, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3