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A4J2F8

- GCSPA_DESRM

UniProt

A4J2F8 - GCSPA_DESRM

Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene

gcvPA

Organism
Desulfotomaculum reducens (strain MI-1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (01 May 2007)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine catabolic process Source: InterPro
    2. nucleoside metabolic process Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Enzyme and pathway databases

    BioCyciDRED349161:GHP6-765-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-protein subunit 1UniRule annotation
    Glycine decarboxylase subunit 1UniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring) subunit 1UniRule annotation
    Gene namesi
    Name:gcvPAUniRule annotation
    Ordered Locus Names:Dred_0722
    OrganismiDesulfotomaculum reducens (strain MI-1)
    Taxonomic identifieri349161 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptococcaceaeDesulfotomaculum
    ProteomesiUP000001556: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 446446Probable glycine dehydrogenase (decarboxylating) subunit 1PRO_1000072768Add
    BLAST

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

    Protein-protein interaction databases

    STRINGi349161.Dred_0722.

    Structurei

    3D structure databases

    ProteinModelPortaliA4J2F8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family. N-terminal subunit subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0403.
    HOGENOMiHOG000132025.
    KOiK00282.
    OMAiRLVGQTE.
    OrthoDBiEOG6XWV3B.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    HAMAPiMF_00712. GcvPA.
    InterProiIPR023010. GcvPA.
    IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006815. GcvPA. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A4J2F8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKFIPHTDEE RRQMLKHLAV ENTDQLFKDI PSELRLNRDL AVEGGLSEME    50
    LQSHMNSLAG LNTGVDQTIC FLGAGAYDHY IPSAVKHILS RSEFYTAYTP 100
    YQPEISQGVL QSIFEYQSMI CLLTGMDAAN ASMYDGASAL AEAALMACAV 150
    TRRDKVLVAS TLHPEYREVV KTYLHGPGIE ISEIAYQEGL SQLADIDQKL 200
    DKKTAAVLVQ YPNFFGCIED LGKIAEQAHA KGALLVVCVD PIALGILKSP 250
    GQCGADIVVG EGQSLGIPLS YGGPYLGFMA CKDKYLRKMP GRIVGQTVDV 300
    EGRRGYVLTL QAREQHIRRD KATSNICSNQ ALCALAATVY LSLVGRQGFK 350
    QVAELCLQKT AYAKELLAAL PGYQLPWQTP VFKEFVLKTK EAPEVINREL 400
    LKENILGGLD LGGYYPELAG HMLFCVTEKR SRREIELLAA RLGAIS 446
    Length:446
    Mass (Da):48,997
    Last modified:May 1, 2007 - v1
    Checksum:i955973E13FA38D95
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000612 Genomic DNA. Translation: ABO49261.1.
    RefSeqiWP_011877097.1. NC_009253.1.
    YP_001112086.1. NC_009253.1.

    Genome annotation databases

    EnsemblBacteriaiABO49261; ABO49261; Dred_0722.
    GeneIDi4957320.
    KEGGidrm:Dred_0722.
    PATRICi21727427. VBIDesRed82656_0801.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000612 Genomic DNA. Translation: ABO49261.1 .
    RefSeqi WP_011877097.1. NC_009253.1.
    YP_001112086.1. NC_009253.1.

    3D structure databases

    ProteinModelPortali A4J2F8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 349161.Dred_0722.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABO49261 ; ABO49261 ; Dred_0722 .
    GeneIDi 4957320.
    KEGGi drm:Dred_0722.
    PATRICi 21727427. VBIDesRed82656_0801.

    Phylogenomic databases

    eggNOGi COG0403.
    HOGENOMi HOG000132025.
    KOi K00282.
    OMAi RLVGQTE.
    OrthoDBi EOG6XWV3B.

    Enzyme and pathway databases

    BioCyci DRED349161:GHP6-765-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    HAMAPi MF_00712. GcvPA.
    InterProi IPR023010. GcvPA.
    IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006815. GcvPA. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MI-1.

    Entry informationi

    Entry nameiGCSPA_DESRM
    AccessioniPrimary (citable) accession number: A4J2F8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: May 1, 2007
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3