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A4J2F8

- GCSPA_DESRM

UniProt

A4J2F8 - GCSPA_DESRM

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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene

gcvPA

Organism
Desulfotomaculum reducens (strain MI-1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine catabolic process Source: InterPro
  2. nucleoside metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciDRED349161:GHP6-765-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 1UniRule annotation
Glycine decarboxylase subunit 1UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 1UniRule annotation
Gene namesi
Name:gcvPAUniRule annotation
Ordered Locus Names:Dred_0722
OrganismiDesulfotomaculum reducens (strain MI-1)
Taxonomic identifieri349161 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptococcaceaeDesulfotomaculum
ProteomesiUP000001556: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 446446Probable glycine dehydrogenase (decarboxylating) subunit 1PRO_1000072768Add
BLAST

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

STRINGi349161.Dred_0722.

Structurei

3D structure databases

ProteinModelPortaliA4J2F8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. N-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0403.
HOGENOMiHOG000132025.
KOiK00282.
OMAiRLVGQTE.
OrthoDBiEOG6XWV3B.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00712. GcvPA.
InterProiIPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFiPIRSF006815. GcvPA. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

A4J2F8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKFIPHTDEE RRQMLKHLAV ENTDQLFKDI PSELRLNRDL AVEGGLSEME
60 70 80 90 100
LQSHMNSLAG LNTGVDQTIC FLGAGAYDHY IPSAVKHILS RSEFYTAYTP
110 120 130 140 150
YQPEISQGVL QSIFEYQSMI CLLTGMDAAN ASMYDGASAL AEAALMACAV
160 170 180 190 200
TRRDKVLVAS TLHPEYREVV KTYLHGPGIE ISEIAYQEGL SQLADIDQKL
210 220 230 240 250
DKKTAAVLVQ YPNFFGCIED LGKIAEQAHA KGALLVVCVD PIALGILKSP
260 270 280 290 300
GQCGADIVVG EGQSLGIPLS YGGPYLGFMA CKDKYLRKMP GRIVGQTVDV
310 320 330 340 350
EGRRGYVLTL QAREQHIRRD KATSNICSNQ ALCALAATVY LSLVGRQGFK
360 370 380 390 400
QVAELCLQKT AYAKELLAAL PGYQLPWQTP VFKEFVLKTK EAPEVINREL
410 420 430 440
LKENILGGLD LGGYYPELAG HMLFCVTEKR SRREIELLAA RLGAIS
Length:446
Mass (Da):48,997
Last modified:May 1, 2007 - v1
Checksum:i955973E13FA38D95
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000612 Genomic DNA. Translation: ABO49261.1.
RefSeqiWP_011877097.1. NC_009253.1.
YP_001112086.1. NC_009253.1.

Genome annotation databases

EnsemblBacteriaiABO49261; ABO49261; Dred_0722.
GeneIDi4957320.
KEGGidrm:Dred_0722.
PATRICi21727427. VBIDesRed82656_0801.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000612 Genomic DNA. Translation: ABO49261.1 .
RefSeqi WP_011877097.1. NC_009253.1.
YP_001112086.1. NC_009253.1.

3D structure databases

ProteinModelPortali A4J2F8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 349161.Dred_0722.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABO49261 ; ABO49261 ; Dred_0722 .
GeneIDi 4957320.
KEGGi drm:Dred_0722.
PATRICi 21727427. VBIDesRed82656_0801.

Phylogenomic databases

eggNOGi COG0403.
HOGENOMi HOG000132025.
KOi K00282.
OMAi RLVGQTE.
OrthoDBi EOG6XWV3B.

Enzyme and pathway databases

BioCyci DRED349161:GHP6-765-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00712. GcvPA.
InterProi IPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
PIRSFi PIRSF006815. GcvPA. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MI-1.

Entry informationi

Entry nameiGCSPA_DESRM
AccessioniPrimary (citable) accession number: A4J2F8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: May 1, 2007
Last modified: October 1, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3