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A4J2F6 (GCST_DESRM) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 32. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Aminomethyltransferase
EC=2.1.2.10
Alternative name(s):
Glycine cleavage system T protein
Gene names
Name:gcvT
Ordered Locus Names:Dred_0720
OrganismDesulfotomaculum reducens (strain MI-1) [Complete proteome] [HAMAP]
Taxonomic identifier349161 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Clostridia › Clostridiales › Peptococcaceae › Desulfotomaculum

Protein attributes

Sequence length364 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine By similarity. HAMAP MF_00259

Catalytic activity

[Protein]-S(8)-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH3. HAMAP MF_00259

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvT family.

Ontologies

Keywords
   Molecular functionAminotransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processglycine catabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: InterPro

   Molecular functionaminomethyltransferase activity

Inferred from electronic annotation. Source: EC

transaminase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 364364Aminomethyltransferase HAMAP MF_00259
PRO_1000071885

Sequences

Sequence LengthMass (Da)Tools
A4J2F6 [UniParc].

Last modified May 1, 2007. Version 1.
Checksum: 10460ECC7C1A902B

FASTA36440,239
        10         20         30         40         50         60 
MQELKRTPLY NIHLAAGAKM VEFGGWLMPV QYEGIIAEHQ AVRSAAGLFD VSHMGEIQIS 

        70         80         90        100        110        120 
GPTAREFVQR LVTNDISRLK PGCAIYSPMC NPQGGTVDDL LVYQLEDQQY LLVVNASNTD 

       130        140        150        160        170        180 
KDFHWIVSQQ VPGVEIQNVS EVTCQLALQG PQAEKILQRL TAVDLSHIKS FCFVYGAVEG 

       190        200        210        220        230        240 
IHCLISRTGY TGEAGFELYF PASHAERVWQ AIMATGATDG LRPVGLGARD TLRFEACLAL 

       250        260        270        280        290        300 
YGHELTDDIS PLMAGLGWTV KFNKPEFVGK EPLLKQKEAG TTYQLVGLEM IDRGIPRQGY 

       310        320        330        340        350        360 
AIFKEGQEVG WITSGTFAPT LGKNMGLGYV EIPFADVGKE LNIMVRNKPL KARIVKKPFY 


KREV

« Hide

References

[1]"Complete sequence of Desulfotomaculum reducens MI-1."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Sims D., Brettin T., Bruce D., Han C., Tapia R., Schmutz J., Larimer F. expand/collapse author list , Land M., Hauser L., Kyrpides N., Kim E., Tebo B.M., Richardson P.
Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MI-1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000612 Genomic DNA. Translation: ABO49259.1.
RefSeqYP_001112084.1. NC_009253.1.

3D structure databases

ProteinModelPortalA4J2F6.
SMRA4J2F6. Positions 4-359.
ModBaseSearch...

Protein-protein interaction databases

STRINGA4J2F6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4957262.
GenomeReviewsGene locus Dred_0720 in contig CP000612_GR.
KEGGdrm:Dred_0720.
PATRIC21727423. VBIDesRed82656_0799.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0404.
HOGENOMHBG299834.
OMAGWEMPIS.
PhylomeDBA4J2F6.

Enzyme and pathway databases

BioCycDRED349161:DRED_0720-MONOMER.

Family and domain databases

HAMAPMF_00259. GcvT.
[Tree]
InterProIPR013977. GCV_T_C.
IPR006222. GCV_T_N.
IPR006223. GcvT.
IPR022903. NH2_Me_Trfase.
[Graphical view]
KOK00605.
PANTHERPTHR13847:SF5. PTHR13847:SF5. 1 hit.
PfamPF01571. GCV_T. 1 hit.
PF08669. GCV_T_C. 1 hit.
[Graphical view]
PIRSFPIRSF006487. GcvT. 1 hit.
TIGRFAMsTIGR00528. GcvT. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCST_DESRM
AccessionPrimary (citable) accession number: A4J2F6
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: May 1, 2007
Last modified: January 25, 2012
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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