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Protein

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Gene

mraY

Organism
Desulfotomaculum reducens (strain MI-1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan.UniRule annotation

Catalytic activityi

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferaseUniRule annotation (EC:2.7.8.13UniRule annotation)
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferaseUniRule annotation
Gene namesi
Name:mraYUniRule annotation
Ordered Locus Names:Dred_0672
OrganismiDesulfotomaculum reducens (strain MI-1)
Taxonomic identifieri349161 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptococcaceaeDesulfotomaculum
Proteomesi
  • UP000001556 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei5 – 25HelicalUniRule annotationAdd BLAST21
Transmembranei52 – 72HelicalUniRule annotationAdd BLAST21
Transmembranei81 – 101HelicalUniRule annotationAdd BLAST21
Transmembranei116 – 136HelicalUniRule annotationAdd BLAST21
Transmembranei148 – 168HelicalUniRule annotationAdd BLAST21
Transmembranei181 – 200HelicalUniRule annotationAdd BLAST20
Transmembranei204 – 223HelicalUniRule annotationAdd BLAST20
Transmembranei230 – 250HelicalUniRule annotationAdd BLAST21
Transmembranei256 – 276HelicalUniRule annotationAdd BLAST21
Transmembranei309 – 329HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000906211 – 334Phospho-N-acetylmuramoyl-pentapeptide-transferaseAdd BLAST334

Interactioni

Protein-protein interaction databases

STRINGi349161.Dred_0672.

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 4 family. MraY subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CPY. Bacteria.
COG0472. LUCA.
HOGENOMiHOG000275124.
KOiK01000.
OMAiLMSPLHH.
OrthoDBiPOG091H00VH.

Family and domain databases

CDDicd06852. GT_MraY. 1 hit.
HAMAPiMF_00038. MraY. 1 hit.
InterProiView protein in InterPro
IPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
PANTHERiPTHR22926. PTHR22926. 1 hit.
PfamiView protein in Pfam
PF00953. Glycos_transf_4. 1 hit.
TIGRFAMsiTIGR00445. mraY. 1 hit.
PROSITEiView protein in PROSITE
PS01347. MRAY_1. 1 hit.
PS01348. MRAY_2. 1 hit.

Sequencei

Sequence statusi: Complete.

A4J2A8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDYTVVWLAA GISFLVTLVL GPVTIPLLQR LKFGQTIRAE GPAAHMAKTG
60 70 80 90 100
TPTMGGIMFL IGIAVAGAVL LVSNIPGRAE GLVVLAVTLG YGLIGFLDDF
110 120 130 140 150
IKVVLKRNLG LKAREKILGQ LVFATVLAVV AVFKLGRGTD YIIPFSSGIS
160 170 180 190 200
FDLGWWPFFF LTLFVLLGTS NGVNLTDGLD GLASGATVFT ATAFAILALV
210 220 230 240 250
TGKIGLAIVL AAVVGGCLGF LFYNRHPAKV FMGDTGSLAL GGALGAGAVV
260 270 280 290 300
TRNELLLVVI GGLYVLETLS VIIQVISFKT TGRRVFRMSP LHHHFELSGW
310 320 330
SERKVVRNFW LLSFLFSLVG LLGAQDFWLW LSNR
Length:334
Mass (Da):35,657
Last modified:May 1, 2007 - v1
Checksum:iD5C01943E7538267
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000612 Genomic DNA. Translation: ABO49211.1.
RefSeqiWP_011877047.1. NC_009253.1.

Genome annotation databases

EnsemblBacteriaiABO49211; ABO49211; Dred_0672.
KEGGidrm:Dred_0672.

Similar proteinsi

Entry informationi

Entry nameiMRAY_DESRM
AccessioniPrimary (citable) accession number: A4J2A8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: May 1, 2007
Last modified: June 7, 2017
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families