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Protein

Anthranilate phosphoribosyltransferase

Gene

trpD

Organism
Desulfotomaculum reducens (strain MI-1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).UniRule annotation

Catalytic activityi

N-(5-phospho-D-ribosyl)-anthranilate + diphosphate = anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 2 magnesium ions per monomer.UniRule annotation

Pathwayi: L-tryptophan biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes L-tryptophan from chorismate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Anthranilate phosphoribosyltransferase (Dred_3255), Anthranilate phosphoribosyltransferase (trpD)
  3. N-(5'-phosphoribosyl)anthranilate isomerase (trpF)
  4. Indole-3-glycerol phosphate synthase (trpC)
  5. Tryptophan synthase beta chain (trpB), Tryptophan synthase beta chain (trpB), Tryptophan synthase alpha chain (trpA)
This subpathway is part of the pathway L-tryptophan biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-tryptophan from chorismate, the pathway L-tryptophan biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei80 – 801Anthranilate 1; via carbonyl oxygenUniRule annotation
Binding sitei80 – 801Phosphoribosylpyrophosphate; via amide nitrogenUniRule annotation
Binding sitei88 – 881PhosphoribosylpyrophosphateUniRule annotation
Metal bindingi92 – 921Magnesium 1UniRule annotation
Binding sitei111 – 1111Anthranilate 1UniRule annotation
Binding sitei120 – 1201Phosphoribosylpyrophosphate; via amide nitrogenUniRule annotation
Binding sitei166 – 1661Anthranilate 2UniRule annotation
Metal bindingi225 – 2251Magnesium 2UniRule annotation
Metal bindingi226 – 2261Magnesium 1UniRule annotation
Metal bindingi226 – 2261Magnesium 2UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciDRED349161:GHP6-276-MONOMER.
UniPathwayiUPA00035; UER00041.

Names & Taxonomyi

Protein namesi
Recommended name:
Anthranilate phosphoribosyltransferaseUniRule annotation (EC:2.4.2.18UniRule annotation)
Gene namesi
Name:trpDUniRule annotation
Ordered Locus Names:Dred_0250
OrganismiDesulfotomaculum reducens (strain MI-1)
Taxonomic identifieri349161 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptococcaceaeDesulfotomaculum
Proteomesi
  • UP000001556 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 345345Anthranilate phosphoribosyltransferasePRO_0000325422Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi349161.Dred_0250.

Structurei

3D structure databases

ProteinModelPortaliA4J146.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni83 – 842Phosphoribosylpyrophosphate bindingUniRule annotation
Regioni90 – 934Phosphoribosylpyrophosphate bindingUniRule annotation
Regioni108 – 1169Phosphoribosylpyrophosphate bindingUniRule annotation

Sequence similaritiesi

Belongs to the anthranilate phosphoribosyltransferase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108I0Q. Bacteria.
COG0547. LUCA.
HOGENOMiHOG000230451.
KOiK00766.
OMAiMIVLNAG.
OrthoDBiEOG6D5G6B.

Family and domain databases

Gene3Di3.40.1030.10. 1 hit.
HAMAPiMF_00211. TrpD.
InterProiIPR005940. Anthranilate_Pribosyl_Tfrase.
IPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
[Graphical view]
PfamiPF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
[Graphical view]
SUPFAMiSSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
TIGRFAMsiTIGR01245. trpD. 1 hit.

Sequencei

Sequence statusi: Complete.

A4J146-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MITEAIQKVV AGINLSEAEA METMQEVMEG KATQAQIASL LTALHLKGET
60 70 80 90 100
VPEITGFART MRTKVIRVQT KRRNLVDTCG TGGDGANTFN ISTACAFVLA
110 120 130 140 150
GAGLPVAKHG NRSVSSKCGS ADVLEQLGVF VQLTPEEAGL CLDQVGIAFL
160 170 180 190 200
FAPLLHGAMK YAAAPRKEIG IRTVFNILGP LTNPAFAENQ VLGVYSSDLA
210 220 230 240 250
PVLAQVLANL GTKRSFVIHG CGGLDEISLA GEALVYEVKD NQVKEMIIDP
260 270 280 290 300
MDYGLDRAPI SALAGGDAKR NARMIKNILS GAPGPQRDTI IINAALGLIA
310 320 330 340
GGLVRDLAMG IRLAEQIIDE GYALKKLNLL VEFSQTLVGR RSAAL
Length:345
Mass (Da):36,422
Last modified:May 1, 2007 - v1
Checksum:i6AAFD32683CB30DD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000612 Genomic DNA. Translation: ABO48799.1.
RefSeqiWP_011876637.1. NC_009253.1.

Genome annotation databases

EnsemblBacteriaiABO48799; ABO48799; Dred_0250.
KEGGidrm:Dred_0250.
PATRICi21726300. VBIDesRed82656_0259.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000612 Genomic DNA. Translation: ABO48799.1.
RefSeqiWP_011876637.1. NC_009253.1.

3D structure databases

ProteinModelPortaliA4J146.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi349161.Dred_0250.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABO48799; ABO48799; Dred_0250.
KEGGidrm:Dred_0250.
PATRICi21726300. VBIDesRed82656_0259.

Phylogenomic databases

eggNOGiENOG4108I0Q. Bacteria.
COG0547. LUCA.
HOGENOMiHOG000230451.
KOiK00766.
OMAiMIVLNAG.
OrthoDBiEOG6D5G6B.

Enzyme and pathway databases

UniPathwayiUPA00035; UER00041.
BioCyciDRED349161:GHP6-276-MONOMER.

Family and domain databases

Gene3Di3.40.1030.10. 1 hit.
HAMAPiMF_00211. TrpD.
InterProiIPR005940. Anthranilate_Pribosyl_Tfrase.
IPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
[Graphical view]
PfamiPF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
[Graphical view]
SUPFAMiSSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
TIGRFAMsiTIGR01245. trpD. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MI-1.

Entry informationi

Entry nameiTRPD_DESRM
AccessioniPrimary (citable) accession number: A4J146
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: May 1, 2007
Last modified: November 11, 2015
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.