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A4J0S6

- FTHS_DESRM

UniProt

A4J0S6 - FTHS_DESRM

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Protein
Formate--tetrahydrofolate ligase
Gene
fhs, Dred_0129
Organism
Desulfotomaculum reducens (strain MI-1)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi68 – 758ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciDRED349161:GHP6-142-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs
Ordered Locus Names:Dred_0129
OrganismiDesulfotomaculum reducens (strain MI-1)
Taxonomic identifieri349161 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptococcaceaeDesulfotomaculum
ProteomesiUP000001556: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 567567Formate--tetrahydrofolate ligaseUniRule annotation
PRO_0000333314Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi349161.Dred_0129.

Structurei

3D structure databases

ProteinModelPortaliA4J0S6.
SMRiA4J0S6. Positions 7-565.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiCIMHAGP.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4J0S6-1 [UniParc]FASTAAdd to Basket

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MKKVPSDLEI AQAHEMIPIA EIAKNIGLGE DDIDLYGKYK AKISLDVLRK    50
FNDRAMGKLI DITAITPTPL GEGKTVTTIG LCQGLGKIGK KVITTLRQPS 100
MGPVFGIKGG AAGGGYSQVV PMEDINIHFT GDIHAVEAAN NLLAAMIDTS 150
ILLGNPLNID PMTVMWNRVL DTNDRALRDI VVGLGGKENG YPRQTSFDMA 200
VASEVMAILA LAENLHDLRQ RLGRIIVAYT YDGKPVTAED LKAAGAMTVI 250
MKEALKPNLV QTLEGQACIM HAGPFANIAH GNNSVLADKI ALNLADYVVT 300
ESGFGSDLGM EKFMDIKCRQ SGLRPSCVVI TCTIRALKMH GGLGNVVAGK 350
PLPEELTREN LPALEKGCAN LAHHIKVASY YGVPVVVSIN RFTPDTDAEV 400
DLVRKKALEA GALGAYPITV WAEGGEGAIE LAEAVVAACE KTADFQLLYP 450
DNLSIKEKIE VLATKVYNAD GVVFEPLAER KIKQFEDLGL GHLPICMAKT 500
HLSISHDPAM KGLPKNYIFP IRDIRASVGA GFLYPLAGAM RTMPGLGSKP 550
AAHNVDIDEY GRTVGLF 567
Length:567
Mass (Da):60,771
Last modified:May 1, 2007 - v1
Checksum:i246CA1784F2A0B40
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000612 Genomic DNA. Translation: ABO48679.1.
RefSeqiWP_011876523.1. NC_009253.1.
YP_001111504.1. NC_009253.1.

Genome annotation databases

EnsemblBacteriaiABO48679; ABO48679; Dred_0129.
GeneIDi4958473.
KEGGidrm:Dred_0129.
PATRICi21726028. VBIDesRed82656_0137.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000612 Genomic DNA. Translation: ABO48679.1 .
RefSeqi WP_011876523.1. NC_009253.1.
YP_001111504.1. NC_009253.1.

3D structure databases

ProteinModelPortali A4J0S6.
SMRi A4J0S6. Positions 7-565.
ModBasei Search...

Protein-protein interaction databases

STRINGi 349161.Dred_0129.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABO48679 ; ABO48679 ; Dred_0129 .
GeneIDi 4958473.
KEGGi drm:Dred_0129.
PATRICi 21726028. VBIDesRed82656_0137.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi CIMHAGP.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci DRED349161:GHP6-142-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MI-1.

Entry informationi

Entry nameiFTHS_DESRM
AccessioniPrimary (citable) accession number: A4J0S6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 1, 2007
Last modified: September 3, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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