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A4J0S6

- FTHS_DESRM

UniProt

A4J0S6 - FTHS_DESRM

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Desulfotomaculum reducens (strain MI-1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 48 (01 Oct 2014)
      Sequence version 1 (01 May 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi68 – 758ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciDRED349161:GHP6-142-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:Dred_0129
    OrganismiDesulfotomaculum reducens (strain MI-1)
    Taxonomic identifieri349161 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptococcaceaeDesulfotomaculum
    ProteomesiUP000001556: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 567567Formate--tetrahydrofolate ligasePRO_0000333314Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi349161.Dred_0129.

    Structurei

    3D structure databases

    ProteinModelPortaliA4J0S6.
    SMRiA4J0S6. Positions 7-565.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiCIMHAGP.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A4J0S6-1 [UniParc]FASTAAdd to Basket

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    MKKVPSDLEI AQAHEMIPIA EIAKNIGLGE DDIDLYGKYK AKISLDVLRK    50
    FNDRAMGKLI DITAITPTPL GEGKTVTTIG LCQGLGKIGK KVITTLRQPS 100
    MGPVFGIKGG AAGGGYSQVV PMEDINIHFT GDIHAVEAAN NLLAAMIDTS 150
    ILLGNPLNID PMTVMWNRVL DTNDRALRDI VVGLGGKENG YPRQTSFDMA 200
    VASEVMAILA LAENLHDLRQ RLGRIIVAYT YDGKPVTAED LKAAGAMTVI 250
    MKEALKPNLV QTLEGQACIM HAGPFANIAH GNNSVLADKI ALNLADYVVT 300
    ESGFGSDLGM EKFMDIKCRQ SGLRPSCVVI TCTIRALKMH GGLGNVVAGK 350
    PLPEELTREN LPALEKGCAN LAHHIKVASY YGVPVVVSIN RFTPDTDAEV 400
    DLVRKKALEA GALGAYPITV WAEGGEGAIE LAEAVVAACE KTADFQLLYP 450
    DNLSIKEKIE VLATKVYNAD GVVFEPLAER KIKQFEDLGL GHLPICMAKT 500
    HLSISHDPAM KGLPKNYIFP IRDIRASVGA GFLYPLAGAM RTMPGLGSKP 550
    AAHNVDIDEY GRTVGLF 567
    Length:567
    Mass (Da):60,771
    Last modified:May 1, 2007 - v1
    Checksum:i246CA1784F2A0B40
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000612 Genomic DNA. Translation: ABO48679.1.
    RefSeqiWP_011876523.1. NC_009253.1.
    YP_001111504.1. NC_009253.1.

    Genome annotation databases

    EnsemblBacteriaiABO48679; ABO48679; Dred_0129.
    GeneIDi4958473.
    KEGGidrm:Dred_0129.
    PATRICi21726028. VBIDesRed82656_0137.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000612 Genomic DNA. Translation: ABO48679.1 .
    RefSeqi WP_011876523.1. NC_009253.1.
    YP_001111504.1. NC_009253.1.

    3D structure databases

    ProteinModelPortali A4J0S6.
    SMRi A4J0S6. Positions 7-565.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 349161.Dred_0129.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABO48679 ; ABO48679 ; Dred_0129 .
    GeneIDi 4958473.
    KEGGi drm:Dred_0129.
    PATRICi 21726028. VBIDesRed82656_0137.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi CIMHAGP.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci DRED349161:GHP6-142-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MI-1.

    Entry informationi

    Entry nameiFTHS_DESRM
    AccessioniPrimary (citable) accession number: A4J0S6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: May 1, 2007
    Last modified: October 1, 2014
    This is version 48 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3