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A4IZL2 (A4IZL2_FRATW) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Peptide deformylase 1 HAMAP MF_00163
Short name=PDF 1 HAMAP MF_00163
EC=3.5.1.88 HAMAP MF_00163
Alternative name(s):
Polypeptide deformylase 1 HAMAP MF_00163
Gene names
Name:def1 HAMAP MF_00163 EMBL ABO47362.1
Ordered Locus Names:FTW_1671
OrganismFrancisella tularensis subsp. tularensis (strain WY96-3418) [Complete proteome] [HAMAP]
Taxonomic identifier418136 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Thiotrichales › Francisellaceae › Francisella

Protein attributes

Sequence length210 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions By similarity. HAMAP MF_00163

Catalytic activity

Formyl-L-methionyl peptide + H2O = formate + methionyl peptide. HAMAP MF_00163 SAAS SAAS000181

Cofactor

Binds 1 Fe2+ ion By similarity. HAMAP MF_00163

Sequence similarities

Belongs to the polypeptide deformylase family. HAMAP MF_00163 RuleBase RU003335

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site1561 By similarity HAMAP MF_00163
Metal binding1121Iron By similarity HAMAP MF_00163
Metal binding1551Iron By similarity HAMAP MF_00163
Metal binding1591Iron By similarity HAMAP MF_00163

Sequences

Sequence LengthMass (Da)Tools
A4IZL2 [UniParc].

Last modified May 1, 2007. Version 1.
Checksum: 6A6952A86B639AD7

FASTA21024,144
        10         20         30         40         50         60 
MVVNIKMQQM KSQFIQYNDS NNKVLYQKCK PVADIQNAEI QNIITEMHEK MQGNGIGLAA 

        70         80         90        100        110        120 
NQIGYPYQIF MIEFDSSNAR YPFSFDSVPY QVFINPKITK ASKQRVSFWH GCLSALGEKR 

       130        140        150        160        170        180 
GKLATYKEIE YEAYNQHGEK ITGKLDSIAA IIFQHEFNHL LGSVYVDFDT EYIDNEELQA 

       190        200        210 
KFASGELKPY QECGEEVPLL LEKYQIGKNI

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References

[1]"Complete genomic characterization of a pathogenic A.II strain of Francisella tularensis subspecies tularensis."
Beckstrom-Sternberg S.M., Auerbach R.K., Godbole S., Pearson J.V., Beckstrom-Sternberg J.S., Deng Z., Munk C., Kubota K., Zhou Y., Bruce D., Noronha J., Scheuermann R.H., Wang A., Wei X., Wang J., Hao J., Wagner D.M., Brettin T.S. expand/collapse author list , Brown N., Gilna P., Keim P.S.
PLoS ONE 2:E947-E947(2007) [PubMed: 17895988] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000608 Genomic DNA. Translation: ABO47362.1.
RefSeqYP_001122484.1. NC_009257.1.

3D structure databases

ProteinModelPortalA4IZL2.
ModBaseSearch...

Protein-protein interaction databases

STRINGA4IZL2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4959206.
GenomeReviewsGene locus FTW_1671 in contig CP000608_GR.
KEGGftw:FTW_1671.
PATRIC17970823. VBIFraTul58433_1715.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0242.
HOGENOMHBG482680.
OMAHNERYPD.
ProtClustDBCLSK934502.

Family and domain databases

HAMAPMF_00163. Pep_deformylase.
[Tree]
InterProIPR000181. Fmet_deformylase.
IPR023635. Peptide_deformylase.
[Graphical view]
Gene3DG3DSA:3.90.45.10. Fmet_deformylase. 1 hit.
KOK01462.
PANTHERPTHR10458. Fmet_deformylase. 1 hit.
PfamPF01327. Pep_deformylase. 1 hit.
[Graphical view]
PIRSFPIRSF004749. Pep_def. 1 hit.
PRINTSPR01576. PDEFORMYLASE.
SUPFAMSSF56420. Fmet_deformylase. 1 hit.
ProtoNetSearch...

Entry information

Entry nameA4IZL2_FRATW
AccessionPrimary (citable) accession number: A4IZL2
Entry history
Integrated into UniProtKB/TrEMBL: May 1, 2007
Last sequence update: May 1, 2007
Last modified: December 14, 2011
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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