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A4IZH1 (A4IZH1_FRATW) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Phosphoenolpyruvate carboxykinase [ATP] HAMAP-Rule MF_00453

Short name=PCK HAMAP-Rule MF_00453
Short name=PEP carboxykinase HAMAP-Rule MF_00453
Short name=PEPCK HAMAP-Rule MF_00453
EC=4.1.1.49 HAMAP-Rule MF_00453
Alternative name(s):
Phosphoenolpyruvate carboxylase HAMAP-Rule MF_00453
Gene names
Name:pckA HAMAP-Rule MF_00453 EMBL ABO47321.1
Ordered Locus Names:FTW_1621 EMBL ABO47321.1
OrganismFrancisella tularensis subsp. tularensis (strain WY96-3418) [Complete proteome] [HAMAP] EMBL ABO47321.1
Taxonomic identifier418136 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella

Protein attributes

Sequence length530 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA By similarity. HAMAP-Rule MF_00453

Catalytic activity

ATP + oxaloacetate = ADP + phosphoenolpyruvate + CO2. HAMAP-Rule MF_00453 SAAS SAAS001272

Cofactor

Binds 1 manganese ion per subunit By similarity. HAMAP-Rule MF_00453

Pathway

Carbohydrate biosynthesis; gluconeogenesis. HAMAP-Rule MF_00453 SAAS SAAS001272

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00453

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00453.

Sequence similarities

Belongs to the phosphoenolpyruvate carboxykinase [ATP] family. HAMAP-Rule MF_00453

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding439 – 4402ATP By similarity HAMAP-Rule MF_00453

Sites

Metal binding2021Manganese By similarity HAMAP-Rule MF_00453
Binding site571Substrate By similarity HAMAP-Rule MF_00453
Binding site1961Substrate By similarity HAMAP-Rule MF_00453
Binding site2021ATP By similarity HAMAP-Rule MF_00453
Binding site2021Substrate By similarity HAMAP-Rule MF_00453
Binding site4451ATP By similarity HAMAP-Rule MF_00453

Sequences

Sequence LengthMass (Da)Tools
A4IZH1 [UniParc].

Last modified May 1, 2007. Version 1.
Checksum: 5D6C06091201432B

FASTA53060,751
        10         20         30         40         50         60 
MLMDPSTIDE YKYLYTCENV HKNLSLQELA KYAHNSDGFI CYDNKTLVVD SGEIKGRLPD 

        70         80         90        100        110        120 
DKYIVETKYA KKNIWWSENG SDNKRLKRKN WKLIKQRLCQ EVATKDLFVV DGFYNHDERY 

       130        140        150        160        170        180 
TIAVRLITTQ ASAAYFFKLI SITPSEKELQ SFEPQWVIMH SPQTQIEDYQ DLDLNSSKVI 

       190        200        210        220        230        240 
ATNLKQRESI LVGTMYLAEI NKVLLSIMSY YLLLNDIGVF YCAVSVDAEA NSTIFFGLSG 

       250        260        270        280        290        300 
SGKTTLALDQ NKSLVANEAI AWTEMRGVYS LESGLTIKSA SFKKDDPRIK QALAGDLLIE 

       310        320        330        340        350        360 
NPNFDDSHNI IFGEKNSSQS NTYVTFPREN FVNVINTDNP NTIIFLVKDA KGVLPRVAKL 

       370        380        390        400        410        420 
SKGQAIYYFL SGYTSTSIGV EAGVTEPKPE FTSCYAQPFL LLKPTRYASI LRQRLKHSNA 

       430        440        450        460        470        480 
KIYMINVGWI EGDYKTGRRV PVEETKLIVN YLLTKPENVS FKFTRQKYFN FKALTSINDN 

       490        500        510        520        530 
GQELQLTNNW SDSAEYKKEY KSLARAFIKN YEQFENDDFA LKYKKFEPII 

« Hide

References

[1]"Complete genomic characterization of a pathogenic A.II strain of Francisella tularensis subspecies tularensis."
Beckstrom-Sternberg S.M., Auerbach R.K., Godbole S., Pearson J.V., Beckstrom-Sternberg J.S., Deng Z., Munk C., Kubota K., Zhou Y., Bruce D., Noronha J., Scheuermann R.H., Wang A., Wei X., Wang J., Hao J., Wagner D.M., Brettin T.S. expand/collapse author list , Brown N., Gilna P., Keim P.S.
PLoS ONE 2:E947-E947(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: WY96-3418 EMBL ABO47321.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000608 Genomic DNA. Translation: ABO47321.1.
RefSeqYP_001122443.1. NC_009257.1.

3D structure databases

ProteinModelPortalA4IZH1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING418136.FTW_1621.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABO47321; ABO47321; FTW_1621.
GeneID4959977.
KEGGftw:FTW_1621.
PATRIC17970721. VBIFraTul58433_1665.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1866.
HOGENOMHOG000062821.
KOK01610.
OMARYAGEMK.
OrthoDBEOG6DG2RK.
ProtClustDBPRK09344.

Enzyme and pathway databases

BioCycFTUL418136:GHXJ-1499-MONOMER.
UniPathwayUPA00138.

Family and domain databases

Gene3D3.40.449.10. 1 hit.
3.90.228.20. 2 hits.
HAMAPMF_00453. PEPCK_ATP.
InterProIPR001272. PEP_carboxykinase_ATP.
IPR013035. PEP_carboxykinase_C.
IPR008210. PEP_carboxykinase_N.
[Graphical view]
PfamPF01293. PEPCK_ATP. 1 hit.
[Graphical view]
PIRSFPIRSF006294. PEP_crbxkin. 1 hit.
SUPFAMSSF68923. SSF68923. 1 hit.
ProtoNetSearch...

Entry information

Entry nameA4IZH1_FRATW
AccessionPrimary (citable) accession number: A4IZH1
Entry history
Integrated into UniProtKB/TrEMBL: May 1, 2007
Last sequence update: May 1, 2007
Last modified: February 19, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)