SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

A4IZH1

- A4IZH1_FRATW

UniProt

A4IZH1 - A4IZH1_FRATW

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Phosphoenolpyruvate carboxykinase [ATP]

Gene
pckA, FTW_1621
Organism
Francisella tularensis subsp. tularensis (strain WY96-3418)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA By similarity.UniRule annotation

Catalytic activityi

ATP + oxaloacetate = ADP + phosphoenolpyruvate + CO2.UniRule annotationSAAS annotations

Cofactori

Binds 1 manganese ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei57 – 571Substrate By similarityUniRule annotation
Binding sitei196 – 1961Substrate By similarityUniRule annotation
Metal bindingi202 – 2021Manganese By similarityUniRule annotation
Binding sitei202 – 2021ATP By similarityUniRule annotation
Binding sitei202 – 2021Substrate By similarityUniRule annotation
Binding sitei445 – 4451ATP By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi439 – 4402ATP By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. kinase activity Source: UniProtKB-KW
  3. metal ion binding Source: UniProtKB-KW
  4. phosphoenolpyruvate carboxykinase (ATP) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

DecarboxylaseUniRule annotationSAAS annotations, KinaseImported, Lyase, Transferase

Keywords - Biological processi

GluconeogenesisUniRule annotationSAAS annotations

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, ManganeseUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding, PyruvateImported

Enzyme and pathway databases

BioCyciFTUL418136:GHXJ-1499-MONOMER.
UniPathwayiUPA00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxykinase [ATP]UniRule annotation (EC:4.1.1.49UniRule annotation)
Short name:
PCKUniRule annotation
Short name:
PEP carboxykinaseUniRule annotation
Short name:
PEPCKUniRule annotation
Alternative name(s):
Phosphoenolpyruvate carboxylase
Gene namesi
Name:pckAUniRule annotationImported
Ordered Locus Names:FTW_1621Imported
OrganismiFrancisella tularensis subsp. tularensis (strain WY96-3418)Imported
Taxonomic identifieri418136 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella
ProteomesiUP000002285: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi418136.FTW_1621.

Structurei

3D structure databases

ProteinModelPortaliA4IZH1.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1866.
HOGENOMiHOG000062821.
KOiK01610.
OMAiGADPEHY.
OrthoDBiEOG6DG2RK.

Family and domain databases

Gene3Di3.40.449.10. 1 hit.
3.90.228.20. 2 hits.
HAMAPiMF_00453. PEPCK_ATP.
InterProiIPR001272. PEP_carboxykinase_ATP.
IPR013035. PEP_carboxykinase_C.
IPR008210. PEP_carboxykinase_N.
[Graphical view]
PfamiPF01293. PEPCK_ATP. 1 hit.
[Graphical view]
PIRSFiPIRSF006294. PEP_crbxkin. 1 hit.
SUPFAMiSSF68923. SSF68923. 1 hit.

Sequencei

Sequence statusi: Complete.

A4IZH1-1 [UniParc]FASTAAdd to Basket

« Hide

MLMDPSTIDE YKYLYTCENV HKNLSLQELA KYAHNSDGFI CYDNKTLVVD    50
SGEIKGRLPD DKYIVETKYA KKNIWWSENG SDNKRLKRKN WKLIKQRLCQ 100
EVATKDLFVV DGFYNHDERY TIAVRLITTQ ASAAYFFKLI SITPSEKELQ 150
SFEPQWVIMH SPQTQIEDYQ DLDLNSSKVI ATNLKQRESI LVGTMYLAEI 200
NKVLLSIMSY YLLLNDIGVF YCAVSVDAEA NSTIFFGLSG SGKTTLALDQ 250
NKSLVANEAI AWTEMRGVYS LESGLTIKSA SFKKDDPRIK QALAGDLLIE 300
NPNFDDSHNI IFGEKNSSQS NTYVTFPREN FVNVINTDNP NTIIFLVKDA 350
KGVLPRVAKL SKGQAIYYFL SGYTSTSIGV EAGVTEPKPE FTSCYAQPFL 400
LLKPTRYASI LRQRLKHSNA KIYMINVGWI EGDYKTGRRV PVEETKLIVN 450
YLLTKPENVS FKFTRQKYFN FKALTSINDN GQELQLTNNW SDSAEYKKEY 500
KSLARAFIKN YEQFENDDFA LKYKKFEPII 530
Length:530
Mass (Da):60,751
Last modified:May 1, 2007 - v1
Checksum:i5D6C06091201432B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000608 Genomic DNA. Translation: ABO47321.1.
RefSeqiYP_001122443.1. NC_009257.1.

Genome annotation databases

EnsemblBacteriaiABO47321; ABO47321; FTW_1621.
GeneIDi4959977.
KEGGiftw:FTW_1621.
PATRICi17970721. VBIFraTul58433_1665.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000608 Genomic DNA. Translation: ABO47321.1 .
RefSeqi YP_001122443.1. NC_009257.1.

3D structure databases

ProteinModelPortali A4IZH1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 418136.FTW_1621.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABO47321 ; ABO47321 ; FTW_1621 .
GeneIDi 4959977.
KEGGi ftw:FTW_1621.
PATRICi 17970721. VBIFraTul58433_1665.

Phylogenomic databases

eggNOGi COG1866.
HOGENOMi HOG000062821.
KOi K01610.
OMAi GADPEHY.
OrthoDBi EOG6DG2RK.

Enzyme and pathway databases

UniPathwayi UPA00138 .
BioCyci FTUL418136:GHXJ-1499-MONOMER.

Family and domain databases

Gene3Di 3.40.449.10. 1 hit.
3.90.228.20. 2 hits.
HAMAPi MF_00453. PEPCK_ATP.
InterProi IPR001272. PEP_carboxykinase_ATP.
IPR013035. PEP_carboxykinase_C.
IPR008210. PEP_carboxykinase_N.
[Graphical view ]
Pfami PF01293. PEPCK_ATP. 1 hit.
[Graphical view ]
PIRSFi PIRSF006294. PEP_crbxkin. 1 hit.
SUPFAMi SSF68923. SSF68923. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: WY96-3418Imported.

Entry informationi

Entry nameiA4IZH1_FRATW
AccessioniPrimary (citable) accession number: A4IZH1
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2007
Last sequence update: May 1, 2007
Last modified: June 11, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

Similar proteinsi