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A4IZH1

- A4IZH1_FRATW

UniProt

A4IZH1 - A4IZH1_FRATW

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Protein

Phosphoenolpyruvate carboxykinase [ATP]

Gene

pckA

Organism
Francisella tularensis subsp. tularensis (strain WY96-3418)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.UniRule annotation

Catalytic activityi

ATP + oxaloacetate = ADP + phosphoenolpyruvate + CO2.UniRule annotationSAAS annotation

Cofactori

Note: Binds 1 manganese ion per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei57 – 571SubstrateUniRule annotation
Binding sitei196 – 1961SubstrateUniRule annotation
Metal bindingi202 – 2021ManganeseUniRule annotation
Binding sitei202 – 2021ATPUniRule annotation
Binding sitei202 – 2021SubstrateUniRule annotation
Binding sitei445 – 4451ATPUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi439 – 4402ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. kinase activity Source: UniProtKB-KW
  3. metal ion binding Source: UniProtKB-KW
  4. phosphoenolpyruvate carboxykinase (ATP) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

DecarboxylaseUniRule annotationSAAS annotation, KinaseImported, Lyase, Transferase

Keywords - Biological processi

GluconeogenesisUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding, PyruvateImported

Enzyme and pathway databases

BioCyciFTUL418136:GHXJ-1499-MONOMER.
UniPathwayiUPA00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxykinase [ATP]UniRule annotation (EC:4.1.1.49UniRule annotation)
Short name:
PCKUniRule annotation
Short name:
PEP carboxykinaseUniRule annotation
Short name:
PEPCKUniRule annotation
Alternative name(s):
Phosphoenolpyruvate carboxylaseUniRule annotation
Gene namesi
Name:pckAUniRule annotationImported
Ordered Locus Names:FTW_1621Imported
OrganismiFrancisella tularensis subsp. tularensis (strain WY96-3418)Imported
Taxonomic identifieri418136 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella
ProteomesiUP000002285: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi418136.FTW_1621.

Structurei

3D structure databases

ProteinModelPortaliA4IZH1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the phosphoenolpyruvate carboxykinase [ATP] family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1866.
HOGENOMiHOG000062821.
KOiK01610.
OMAiGADPEHY.
OrthoDBiEOG6DG2RK.

Family and domain databases

Gene3Di3.40.449.10. 1 hit.
3.90.228.20. 2 hits.
HAMAPiMF_00453. PEPCK_ATP.
InterProiIPR001272. PEP_carboxykinase_ATP.
IPR013035. PEP_carboxykinase_C.
IPR008210. PEP_carboxykinase_N.
[Graphical view]
PfamiPF01293. PEPCK_ATP. 1 hit.
[Graphical view]
PIRSFiPIRSF006294. PEP_crbxkin. 1 hit.
SUPFAMiSSF68923. SSF68923. 1 hit.

Sequencei

Sequence statusi: Complete.

A4IZH1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLMDPSTIDE YKYLYTCENV HKNLSLQELA KYAHNSDGFI CYDNKTLVVD
60 70 80 90 100
SGEIKGRLPD DKYIVETKYA KKNIWWSENG SDNKRLKRKN WKLIKQRLCQ
110 120 130 140 150
EVATKDLFVV DGFYNHDERY TIAVRLITTQ ASAAYFFKLI SITPSEKELQ
160 170 180 190 200
SFEPQWVIMH SPQTQIEDYQ DLDLNSSKVI ATNLKQRESI LVGTMYLAEI
210 220 230 240 250
NKVLLSIMSY YLLLNDIGVF YCAVSVDAEA NSTIFFGLSG SGKTTLALDQ
260 270 280 290 300
NKSLVANEAI AWTEMRGVYS LESGLTIKSA SFKKDDPRIK QALAGDLLIE
310 320 330 340 350
NPNFDDSHNI IFGEKNSSQS NTYVTFPREN FVNVINTDNP NTIIFLVKDA
360 370 380 390 400
KGVLPRVAKL SKGQAIYYFL SGYTSTSIGV EAGVTEPKPE FTSCYAQPFL
410 420 430 440 450
LLKPTRYASI LRQRLKHSNA KIYMINVGWI EGDYKTGRRV PVEETKLIVN
460 470 480 490 500
YLLTKPENVS FKFTRQKYFN FKALTSINDN GQELQLTNNW SDSAEYKKEY
510 520 530
KSLARAFIKN YEQFENDDFA LKYKKFEPII
Length:530
Mass (Da):60,751
Last modified:May 1, 2007 - v1
Checksum:i5D6C06091201432B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000608 Genomic DNA. Translation: ABO47321.1.
RefSeqiYP_001122443.1. NC_009257.1.

Genome annotation databases

EnsemblBacteriaiABO47321; ABO47321; FTW_1621.
GeneIDi4959977.
KEGGiftw:FTW_1621.
PATRICi17970721. VBIFraTul58433_1665.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000608 Genomic DNA. Translation: ABO47321.1 .
RefSeqi YP_001122443.1. NC_009257.1.

3D structure databases

ProteinModelPortali A4IZH1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 418136.FTW_1621.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABO47321 ; ABO47321 ; FTW_1621 .
GeneIDi 4959977.
KEGGi ftw:FTW_1621.
PATRICi 17970721. VBIFraTul58433_1665.

Phylogenomic databases

eggNOGi COG1866.
HOGENOMi HOG000062821.
KOi K01610.
OMAi GADPEHY.
OrthoDBi EOG6DG2RK.

Enzyme and pathway databases

UniPathwayi UPA00138 .
BioCyci FTUL418136:GHXJ-1499-MONOMER.

Family and domain databases

Gene3Di 3.40.449.10. 1 hit.
3.90.228.20. 2 hits.
HAMAPi MF_00453. PEPCK_ATP.
InterProi IPR001272. PEP_carboxykinase_ATP.
IPR013035. PEP_carboxykinase_C.
IPR008210. PEP_carboxykinase_N.
[Graphical view ]
Pfami PF01293. PEPCK_ATP. 1 hit.
[Graphical view ]
PIRSFi PIRSF006294. PEP_crbxkin. 1 hit.
SUPFAMi SSF68923. SSF68923. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: WY96-3418Imported.

Entry informationi

Entry nameiA4IZH1_FRATW
AccessioniPrimary (citable) accession number: A4IZH1
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2007
Last sequence update: May 1, 2007
Last modified: November 26, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3