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A4IZH1

- A4IZH1_FRATW

UniProt

A4IZH1 - A4IZH1_FRATW

Protein

Phosphoenolpyruvate carboxykinase [ATP]

Gene

pckA

Organism
Francisella tularensis subsp. tularensis (strain WY96-3418)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (01 May 2007)
      Previous versions | rss
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    Functioni

    Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.UniRule annotation

    Catalytic activityi

    ATP + oxaloacetate = ADP + phosphoenolpyruvate + CO2.UniRule annotationSAAS annotation

    Cofactori

    Binds 1 manganese ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei57 – 571SubstrateUniRule annotation
    Binding sitei196 – 1961SubstrateUniRule annotation
    Metal bindingi202 – 2021ManganeseUniRule annotation
    Binding sitei202 – 2021ATPUniRule annotation
    Binding sitei202 – 2021SubstrateUniRule annotation
    Binding sitei445 – 4451ATPUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi439 – 4402ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. kinase activity Source: UniProtKB-KW
    3. metal ion binding Source: UniProtKB-KW
    4. phosphoenolpyruvate carboxykinase (ATP) activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. gluconeogenesis Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    DecarboxylaseUniRule annotationSAAS annotation, KinaseImported, Lyase, Transferase

    Keywords - Biological processi

    GluconeogenesisUniRule annotationSAAS annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding, PyruvateImported

    Enzyme and pathway databases

    BioCyciFTUL418136:GHXJ-1499-MONOMER.
    UniPathwayiUPA00138.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoenolpyruvate carboxykinase [ATP]UniRule annotation (EC:4.1.1.49UniRule annotation)
    Short name:
    PCKUniRule annotation
    Short name:
    PEP carboxykinaseUniRule annotation
    Short name:
    PEPCKUniRule annotation
    Alternative name(s):
    Phosphoenolpyruvate carboxylaseUniRule annotation
    Gene namesi
    Name:pckAUniRule annotationImported
    Ordered Locus Names:FTW_1621Imported
    OrganismiFrancisella tularensis subsp. tularensis (strain WY96-3418)Imported
    Taxonomic identifieri418136 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella
    ProteomesiUP000002285: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotation

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi418136.FTW_1621.

    Structurei

    3D structure databases

    ProteinModelPortaliA4IZH1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the phosphoenolpyruvate carboxykinase [ATP] family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1866.
    HOGENOMiHOG000062821.
    KOiK01610.
    OMAiGADPEHY.
    OrthoDBiEOG6DG2RK.

    Family and domain databases

    Gene3Di3.40.449.10. 1 hit.
    3.90.228.20. 2 hits.
    HAMAPiMF_00453. PEPCK_ATP.
    InterProiIPR001272. PEP_carboxykinase_ATP.
    IPR013035. PEP_carboxykinase_C.
    IPR008210. PEP_carboxykinase_N.
    [Graphical view]
    PfamiPF01293. PEPCK_ATP. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006294. PEP_crbxkin. 1 hit.
    SUPFAMiSSF68923. SSF68923. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A4IZH1-1 [UniParc]FASTAAdd to Basket

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    MLMDPSTIDE YKYLYTCENV HKNLSLQELA KYAHNSDGFI CYDNKTLVVD    50
    SGEIKGRLPD DKYIVETKYA KKNIWWSENG SDNKRLKRKN WKLIKQRLCQ 100
    EVATKDLFVV DGFYNHDERY TIAVRLITTQ ASAAYFFKLI SITPSEKELQ 150
    SFEPQWVIMH SPQTQIEDYQ DLDLNSSKVI ATNLKQRESI LVGTMYLAEI 200
    NKVLLSIMSY YLLLNDIGVF YCAVSVDAEA NSTIFFGLSG SGKTTLALDQ 250
    NKSLVANEAI AWTEMRGVYS LESGLTIKSA SFKKDDPRIK QALAGDLLIE 300
    NPNFDDSHNI IFGEKNSSQS NTYVTFPREN FVNVINTDNP NTIIFLVKDA 350
    KGVLPRVAKL SKGQAIYYFL SGYTSTSIGV EAGVTEPKPE FTSCYAQPFL 400
    LLKPTRYASI LRQRLKHSNA KIYMINVGWI EGDYKTGRRV PVEETKLIVN 450
    YLLTKPENVS FKFTRQKYFN FKALTSINDN GQELQLTNNW SDSAEYKKEY 500
    KSLARAFIKN YEQFENDDFA LKYKKFEPII 530
    Length:530
    Mass (Da):60,751
    Last modified:May 1, 2007 - v1
    Checksum:i5D6C06091201432B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000608 Genomic DNA. Translation: ABO47321.1.
    RefSeqiYP_001122443.1. NC_009257.1.

    Genome annotation databases

    EnsemblBacteriaiABO47321; ABO47321; FTW_1621.
    GeneIDi4959977.
    KEGGiftw:FTW_1621.
    PATRICi17970721. VBIFraTul58433_1665.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000608 Genomic DNA. Translation: ABO47321.1 .
    RefSeqi YP_001122443.1. NC_009257.1.

    3D structure databases

    ProteinModelPortali A4IZH1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 418136.FTW_1621.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABO47321 ; ABO47321 ; FTW_1621 .
    GeneIDi 4959977.
    KEGGi ftw:FTW_1621.
    PATRICi 17970721. VBIFraTul58433_1665.

    Phylogenomic databases

    eggNOGi COG1866.
    HOGENOMi HOG000062821.
    KOi K01610.
    OMAi GADPEHY.
    OrthoDBi EOG6DG2RK.

    Enzyme and pathway databases

    UniPathwayi UPA00138 .
    BioCyci FTUL418136:GHXJ-1499-MONOMER.

    Family and domain databases

    Gene3Di 3.40.449.10. 1 hit.
    3.90.228.20. 2 hits.
    HAMAPi MF_00453. PEPCK_ATP.
    InterProi IPR001272. PEP_carboxykinase_ATP.
    IPR013035. PEP_carboxykinase_C.
    IPR008210. PEP_carboxykinase_N.
    [Graphical view ]
    Pfami PF01293. PEPCK_ATP. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006294. PEP_crbxkin. 1 hit.
    SUPFAMi SSF68923. SSF68923. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: WY96-3418Imported.

    Entry informationi

    Entry nameiA4IZH1_FRATW
    AccessioniPrimary (citable) accession number: A4IZH1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 1, 2007
    Last sequence update: May 1, 2007
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3