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Protein

Catalase-peroxidase

Gene

katG

Organism
Francisella tularensis subsp. tularensis (strain WY96-3418)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei99 – 991Transition state stabilizerUniRule annotation
Active sitei103 – 1031Proton acceptorUniRule annotation
Metal bindingi264 – 2641Iron (heme axial ligand)UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciFTUL418136:GHXJ-1406-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidaseUniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CPUniRule annotation
Alternative name(s):
Peroxidase/catalaseUniRule annotation
Gene namesi
Name:katGUniRule annotation
Ordered Locus Names:FTW_1518
OrganismiFrancisella tularensis subsp. tularensis (strain WY96-3418)
Taxonomic identifieri418136 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323UniRule annotationAdd
BLAST
Chaini24 – 741718Catalase-peroxidasePRO_0000354796Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki102 ↔ 223Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-249)UniRule annotation
Cross-linki223 ↔ 249Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-102)UniRule annotation

Post-translational modificationi

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA4IZ86.
SMRiA4IZ86. Positions 28-739.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000218110.
KOiK03782.
OMAiYGATTMG.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A4IZ86-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKKIVTALG MSGMLLASSN AIAEDTTTKN DNLSPQSVDL SPLRNLNKLD
60 70 80 90 100
SPMDKDYNYH QAFKKLDTEQ LKKDMQDLLT QSQDWWPADF GNYGPFFIRL
110 120 130 140 150
SWHDAGTYRI YDGRGGANRG QQRFSPLNSW PDNVNLDKAR QLLWPIKQKY
160 170 180 190 200
GDAVSWSDLI VLAGTVSLES MGMKPIGFAF GREDDWQGDD TNWGLSPEEI
210 220 230 240 250
MSSNVRDGKL APAYAATQMG LIYVNPEGPD GKPDIKGAAS EIRQAFRAMG
260 270 280 290 300
MTDKETVALI AGGHTFGKTH GAVPEDKVKQ TIGPAPDKAP IEQQGLGWHN
310 320 330 340 350
SYGTGNGDDT MGSGLEGSWT STPTFWNHDF LHNLYNLDWK KTLSPAGAHQ
360 370 380 390 400
WTPTNAKPEN MVPDAHKPGV KHKPIMFTTD LALKEDDGFN KYTQEFYNNP
410 420 430 440 450
EEFKEEFAKA WFKLTHRDMG PKSRYIGPWI PEQNFIWQDP VPAADYKQVS
460 470 480 490 500
TQDIAQLEQD IINSGLTNQQ LIKTAWDSAS TYRKTDYRGG SNGARIALAP
510 520 530 540 550
EKDWQMNEPA KLEVVLTKLK EIQTNFNNSK TDGTKVSLAD LIVLGGNVGV
560 570 580 590 600
EQAAKQAGYN IQMPFVPGRT DATQAQTDIE SFNYLKTKSD GFINYTDGSV
610 620 630 640 650
SADKLPQTLV EKASMLDLNI PEMTVLVGGM RALDVNYDNS QEGVLTTTPG
660 670 680 690 700
QLNNSFFVNL LDMSTQWKKS DKKDGEYIGI DRKTGKQKWT ASPVDLIFGS
710 720 730 740
NSELKAVAQV YAENGNEQKF VNDFAKAWHK VMMLGRFDVQ Q
Length:741
Mass (Da):82,531
Last modified:May 1, 2007 - v1
Checksum:iEC1228913065308A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000608 Genomic DNA. Translation: ABO47237.1.
RefSeqiWP_003026820.1. NC_009257.1.

Genome annotation databases

EnsemblBacteriaiABO47237; ABO47237; FTW_1518.
KEGGiftw:FTW_1518.
PATRICi17970510. VBIFraTul58433_1561.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000608 Genomic DNA. Translation: ABO47237.1.
RefSeqiWP_003026820.1. NC_009257.1.

3D structure databases

ProteinModelPortaliA4IZ86.
SMRiA4IZ86. Positions 28-739.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABO47237; ABO47237; FTW_1518.
KEGGiftw:FTW_1518.
PATRICi17970510. VBIFraTul58433_1561.

Phylogenomic databases

HOGENOMiHOG000218110.
KOiK03782.
OMAiYGATTMG.

Enzyme and pathway databases

BioCyciFTUL418136:GHXJ-1406-MONOMER.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKATG_FRATW
AccessioniPrimary (citable) accession number: A4IZ86
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: May 1, 2007
Last modified: September 7, 2016
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.