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A4IYB8

- A4IYB8_FRATW

UniProt

A4IYB8 - A4IYB8_FRATW

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Protein
Thymidine kinase
Gene
tdk, FTW_1107
Organism
Francisella tularensis subsp. tularensis (strain WY96-3418)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotations

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei88 – 881Proton acceptor By similarityUniRule annotation
Metal bindingi145 – 1451Zinc By similarityUniRule annotation
Metal bindingi147 – 1471Zinc By similarityUniRule annotation
Metal bindingi187 – 1871Zinc By similarityUniRule annotation
Metal bindingi190 – 1901Zinc By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi9 – 168ATP By similarityUniRule annotation
Nucleotide bindingi87 – 904ATP By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidine kinase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotationsImported, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotationSAAS annotations

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, Metal-bindingUniRule annotation, Nucleotide-binding, ZincUniRule annotation

Enzyme and pathway databases

BioCyciFTUL418136:GHXJ-1043-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotationImported
Ordered Locus Names:FTW_1107Imported
OrganismiFrancisella tularensis subsp. tularensis (strain WY96-3418)Imported
Taxonomic identifieri418136 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella
ProteomesiUP000002285: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi418136.FTW_1107.

Structurei

3D structure databases

ProteinModelPortaliA4IYB8.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1435.
HOGENOMiHOG000076391.
KOiK00857.
OMAiELKTVCH.
OrthoDBiEOG69D3J2.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

A4IYB8-1 [UniParc]FASTAAdd to Basket

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MAKLYFRYSA MDAGKTLDLL KVAYNYEDRD RKPLVLTSAI DKRAGLNKVK    50
SRIGIDQDAY SLTDRDNIFE FVENYNSSNK IDCVLIDEIH FFTQEQVWQL 100
AEIVDELNIP VICYGLRTNY LGQPFETAAL LLAIADTLEE VKTICHCGKK 150
ASFNMMVQNG KAIKQGNPIV VDDDSLKEID TKYVSVCRKH WKEGVYE 197
Length:197
Mass (Da):22,532
Last modified:May 1, 2007 - v1
Checksum:i9C69380805514FB5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000608 Genomic DNA. Translation: ABO46919.1.
RefSeqiYP_001122040.1. NC_009257.1.

Genome annotation databases

EnsemblBacteriaiABO46919; ABO46919; FTW_1107.
GeneIDi4960356.
KEGGiftw:FTW_1107.
PATRICi17969660. VBIFraTul58433_1142.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000608 Genomic DNA. Translation: ABO46919.1 .
RefSeqi YP_001122040.1. NC_009257.1.

3D structure databases

ProteinModelPortali A4IYB8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 418136.FTW_1107.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABO46919 ; ABO46919 ; FTW_1107 .
GeneIDi 4960356.
KEGGi ftw:FTW_1107.
PATRICi 17969660. VBIFraTul58433_1142.

Phylogenomic databases

eggNOGi COG1435.
HOGENOMi HOG000076391.
KOi K00857.
OMAi ELKTVCH.
OrthoDBi EOG69D3J2.

Enzyme and pathway databases

BioCyci FTUL418136:GHXJ-1043-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
HAMAPi MF_00124. Thymidine_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020634. Thymidine_kinase_subgr.
[Graphical view ]
PANTHERi PTHR11441. PTHR11441. 1 hit.
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: WY96-3418Imported.

Entry informationi

Entry nameiA4IYB8_FRATW
AccessioniPrimary (citable) accession number: A4IYB8
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2007
Last sequence update: May 1, 2007
Last modified: June 11, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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