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A4IY87

- RUVC_FRATW

UniProt

A4IY87 - RUVC_FRATW

Protein

Crossover junction endodeoxyribonuclease RuvC

Gene

ruvC

Organism
Francisella tularensis subsp. tularensis (strain WY96-3418)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 48 (01 Oct 2014)
      Sequence version 1 (01 May 2007)
      Previous versions | rss
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    Functioni

    Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.UniRule annotation

    Catalytic activityi

    Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).UniRule annotation

    Cofactori

    Binds 1 magnesium ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi7 – 71MagnesiumUniRule annotation
    Metal bindingi66 – 661MagnesiumUniRule annotation
    Metal bindingi138 – 1381MagnesiumUniRule annotation
    Metal bindingi141 – 1411MagnesiumUniRule annotation

    GO - Molecular functioni

    1. crossover junction endodeoxyribonuclease activity Source: UniProtKB-HAMAP
    2. magnesium ion binding Source: UniProtKB-HAMAP
    3. nucleic acid binding Source: InterPro

    GO - Biological processi

    1. DNA recombination Source: UniProtKB-HAMAP
    2. DNA repair Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase, Nuclease

    Keywords - Biological processi

    DNA damage, DNA recombination, DNA repair

    Keywords - Ligandi

    Magnesium, Metal-binding

    Enzyme and pathway databases

    BioCyciFTUL418136:GHXJ-1010-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Crossover junction endodeoxyribonuclease RuvCUniRule annotation (EC:3.1.22.4UniRule annotation)
    Alternative name(s):
    Holliday junction nuclease RuvCUniRule annotation
    Holliday junction resolvase RuvCUniRule annotation
    Gene namesi
    Name:ruvCUniRule annotation
    Ordered Locus Names:FTW_1072
    OrganismiFrancisella tularensis subsp. tularensis (strain WY96-3418)
    Taxonomic identifieri418136 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella
    ProteomesiUP000002285: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 171171Crossover junction endodeoxyribonuclease RuvCPRO_1000002759Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi418136.FTW_1072.

    Structurei

    3D structure databases

    ProteinModelPortaliA4IY87.
    SMRiA4IY87. Positions 2-156.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the RuvC family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0817.
    HOGENOMiHOG000012181.
    KOiK01159.
    OMAiMQIKLAL.
    OrthoDBiEOG6RG044.

    Family and domain databases

    Gene3Di3.30.420.10. 1 hit.
    HAMAPiMF_00034. RuvC.
    InterProiIPR012337. RNaseH-like_dom.
    IPR020563. X-over_junc_endoDNase_Mg_BS.
    IPR002176. X-over_junc_endoDNase_RuvC.
    [Graphical view]
    PfamiPF02075. RuvC. 1 hit.
    [Graphical view]
    PRINTSiPR00696. RSOLVASERUVC.
    SUPFAMiSSF53098. SSF53098. 1 hit.
    TIGRFAMsiTIGR00228. ruvC. 1 hit.
    PROSITEiPS01321. RUVC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A4IY87-1 [UniParc]FASTAAdd to Basket

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    MVILGIDPGS RITGFGVIKV QDNKIYYVAS GCIRITEITT PKRLKQIADG    50
    ITQIINIYAP TEAAIEQIFM FQNPMGAIKL GQARGVAMCT LAINNLEVSE 100
    YSAKQIKQAV VGTGGAAKSQ VQHMVQSLLG LSKKPPEDAA DALAIAICHY 150
    HSSKSLAKIS GASRVSQKRI K 171
    Length:171
    Mass (Da):18,297
    Last modified:May 1, 2007 - v1
    Checksum:iB0F8E840F4C22DAD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000608 Genomic DNA. Translation: ABO46888.1.
    RefSeqiYP_001122009.1. NC_009257.1.

    Genome annotation databases

    EnsemblBacteriaiABO46888; ABO46888; FTW_1072.
    GeneIDi4958814.
    KEGGiftw:FTW_1072.
    PATRICi17969586. VBIFraTul58433_1105.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000608 Genomic DNA. Translation: ABO46888.1 .
    RefSeqi YP_001122009.1. NC_009257.1.

    3D structure databases

    ProteinModelPortali A4IY87.
    SMRi A4IY87. Positions 2-156.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 418136.FTW_1072.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABO46888 ; ABO46888 ; FTW_1072 .
    GeneIDi 4958814.
    KEGGi ftw:FTW_1072.
    PATRICi 17969586. VBIFraTul58433_1105.

    Phylogenomic databases

    eggNOGi COG0817.
    HOGENOMi HOG000012181.
    KOi K01159.
    OMAi MQIKLAL.
    OrthoDBi EOG6RG044.

    Enzyme and pathway databases

    BioCyci FTUL418136:GHXJ-1010-MONOMER.

    Family and domain databases

    Gene3Di 3.30.420.10. 1 hit.
    HAMAPi MF_00034. RuvC.
    InterProi IPR012337. RNaseH-like_dom.
    IPR020563. X-over_junc_endoDNase_Mg_BS.
    IPR002176. X-over_junc_endoDNase_RuvC.
    [Graphical view ]
    Pfami PF02075. RuvC. 1 hit.
    [Graphical view ]
    PRINTSi PR00696. RSOLVASERUVC.
    SUPFAMi SSF53098. SSF53098. 1 hit.
    TIGRFAMsi TIGR00228. ruvC. 1 hit.
    PROSITEi PS01321. RUVC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: WY96-3418.

    Entry informationi

    Entry nameiRUVC_FRATW
    AccessioniPrimary (citable) accession number: A4IY87
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: May 1, 2007
    Last modified: October 1, 2014
    This is version 48 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3