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Protein

Pyruvate dehydrogenase E1 component

Gene

aceE

Organism
Francisella tularensis subsp. tularensis (strain WY96-3418)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.UniRule annotation

Catalytic activityi

Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2.UniRule annotation

Cofactori

thiamine diphosphateUniRule annotation

GO - Molecular functioni

  1. pyruvate dehydrogenase (acetyl-transferring) activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Ligandi

PyruvateUniRule annotationImported, Thiamine pyrophosphateUniRule annotation

Enzyme and pathway databases

BioCyciFTUL418136:GHXJ-770-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate dehydrogenase E1 componentUniRule annotation (EC:1.2.4.1UniRule annotation)
Gene namesi
Name:aceEImported
Ordered Locus Names:FTW_0808Imported
OrganismiFrancisella tularensis subsp. tularensis (strain WY96-3418)Imported
Taxonomic identifieri418136 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella
ProteomesiUP000002285 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi418136.FTW_0808.

Structurei

3D structure databases

ProteinModelPortaliA4IXM8.
SMRiA4IXM8. Positions 57-891.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiCOG2609.
HOGENOMiHOG000115215.
KOiK00163.
OMAiEVIKVIW.
OrthoDBiEOG6BW4TW.

Family and domain databases

Gene3Di3.40.50.920. 1 hit.
3.40.50.970. 2 hits.
InterProiIPR004660. 2-oxoA_DH_E1.
IPR029061. THDP-binding.
IPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR005474. Transketolase_N.
[Graphical view]
PfamiPF00456. Transketolase_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000156. Pyruvate_dh_E1. 1 hit.
SUPFAMiSSF52518. SSF52518. 2 hits.
SSF52922. SSF52922. 1 hit.
TIGRFAMsiTIGR00759. aceE. 1 hit.

Sequencei

Sequence statusi: Complete.

A4IXM8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDFTKDIDV LETQEWLEAF EDVIKREGAD RAKFLFEQLL AKGSELGIKS
60 70 80 90 100
AYSTAKVKNY VNSIDVSEQP SYPGDIELEQ KIEAINRWNS TVIVAAANKK
110 120 130 140 150
DGSIGGHIGT GAGAMTLYEV GFNHFWKAPN DEHAGDLIFY QGHLSPIVYA
160 170 180 190 200
RSFLEGRITA EQLENFRKQA FNGQNAVSSY PHPYLQPTYW QFPTVSMGLG
210 220 230 240 250
PLQAIYQARF MKYLEARGLA KTSDRKVWAF CGDGEMDEPE SIGSITRAGR
260 270 280 290 300
EGLDNLIFVV NCNLQRLDGL VNGNGNIVEE LADVFAGAGW NVIKVLWSSD
310 320 330 340 350
WDKLLQDPRG GKKLAQRLSE LNDGQFHTIK AHGGAECRRV VFSGDEDLEA
360 370 380 390 400
LAKDMTDDDI QALRRGGHDP LKIYAAYKKA VENPNGRPTL ILPMTVKGYG
410 420 430 440 450
LGEWGESKNI AHNVKKLDTD ALEHIKNRFN VPASKEDIEN YRLIKLDENS
460 470 480 490 500
PEMKYLHSKR KDLGGYIPKR LENKQALEIP SYKDFAKSLL DDSGDREFST
510 520 530 540 550
TTAFVRILSH LAKDKNLGKH IVPITVDESR TFGMEGLFRQ LGIYNPHGQQ
560 570 580 590 600
YVPEDKQQVM FYKESVDGQI LQEGINEQGG FCSWIAAATS YSVHKVPMIP
610 620 630 640 650
FMIYYSMFGF QRFGDLAWAA GDSMAKGFVI GGTSGRTTLN GEGLQHEDGH
660 670 680 690 700
SHIQAGLIPN CISYDPTYAY ELAVILGEGM KRMYVDGDHV YYYITVMNEN
710 720 730 740 750
YSHRAMPEGC EEGIIKGLYK LDEEKKPASK HVQLLGSGSI LREVEAAAKM
760 770 780 790 800
LKEEYGITSN VWSMTSANEL YREAKDVARA NMLHPTAEKK ESYIEKCFKN
810 820 830 840 850
EQGPVIASTD YIKLYTDQLR EFIPHAFVNL GTDGFGRSDT RAALRSFFEV
860 870 880 890
DRYHVVVASL YALYLDGKVE ASEVKAAIEK YNIDPERMAP FYS
Length:893
Mass (Da):100,152
Last modified:May 1, 2007 - v1
Checksum:iBC1FB41EF64DF391
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000608 Genomic DNA. Translation: ABO46680.1.
RefSeqiYP_001121800.1. NC_009257.1.

Genome annotation databases

EnsemblBacteriaiABO46680; ABO46680; FTW_0808.
KEGGiftw:FTW_0808.
PATRICi17969016. VBIFraTul58433_0824.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000608 Genomic DNA. Translation: ABO46680.1.
RefSeqiYP_001121800.1. NC_009257.1.

3D structure databases

ProteinModelPortaliA4IXM8.
SMRiA4IXM8. Positions 57-891.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi418136.FTW_0808.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABO46680; ABO46680; FTW_0808.
KEGGiftw:FTW_0808.
PATRICi17969016. VBIFraTul58433_0824.

Phylogenomic databases

eggNOGiCOG2609.
HOGENOMiHOG000115215.
KOiK00163.
OMAiEVIKVIW.
OrthoDBiEOG6BW4TW.

Enzyme and pathway databases

BioCyciFTUL418136:GHXJ-770-MONOMER.

Family and domain databases

Gene3Di3.40.50.920. 1 hit.
3.40.50.970. 2 hits.
InterProiIPR004660. 2-oxoA_DH_E1.
IPR029061. THDP-binding.
IPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR005474. Transketolase_N.
[Graphical view]
PfamiPF00456. Transketolase_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000156. Pyruvate_dh_E1. 1 hit.
SUPFAMiSSF52518. SSF52518. 2 hits.
SSF52922. SSF52922. 1 hit.
TIGRFAMsiTIGR00759. aceE. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: WY96-3418Imported.

Entry informationi

Entry nameiA4IXM8_FRATW
AccessioniPrimary (citable) accession number: A4IXM8
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2007
Last sequence update: May 1, 2007
Last modified: April 1, 2015
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.