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A4IXM8

- A4IXM8_FRATW

UniProt

A4IXM8 - A4IXM8_FRATW

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Protein

Pyruvate dehydrogenase E1 component

Gene
aceE, FTW_0808
Organism
Francisella tularensis subsp. tularensis (strain WY96-3418)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2 By similarity.UniRule annotation

Catalytic activityi

Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2.UniRule annotation

Cofactori

Thiamine pyrophosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. pyruvate dehydrogenase (acetyl-transferring) activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Ligandi

PyruvateUniRule annotationImported, Thiamine pyrophosphateUniRule annotation

Enzyme and pathway databases

BioCyciFTUL418136:GHXJ-770-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate dehydrogenase E1 componentUniRule annotation (EC:1.2.4.1UniRule annotation)
Gene namesi
Name:aceEImported
Ordered Locus Names:FTW_0808Imported
OrganismiFrancisella tularensis subsp. tularensis (strain WY96-3418)Imported
Taxonomic identifieri418136 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella
ProteomesiUP000002285: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi418136.FTW_0808.

Structurei

3D structure databases

ProteinModelPortaliA4IXM8.
SMRiA4IXM8. Positions 57-891.

Family & Domainsi

Phylogenomic databases

eggNOGiCOG2609.
HOGENOMiHOG000115215.
KOiK00163.
OMAiKGIYKLD.
OrthoDBiEOG6BW4TW.

Family and domain databases

Gene3Di3.40.50.920. 1 hit.
3.40.50.970. 2 hits.
InterProiIPR004660. 2-oxoA_DH_E1.
IPR029061. THDP-binding.
IPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR005474. Transketolase_N.
[Graphical view]
PfamiPF00456. Transketolase_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000156. Pyruvate_dh_E1. 1 hit.
SUPFAMiSSF52518. SSF52518. 2 hits.
SSF52922. SSF52922. 1 hit.
TIGRFAMsiTIGR00759. aceE. 1 hit.

Sequencei

Sequence statusi: Complete.

A4IXM8-1 [UniParc]FASTAAdd to Basket

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MSDFTKDIDV LETQEWLEAF EDVIKREGAD RAKFLFEQLL AKGSELGIKS    50
AYSTAKVKNY VNSIDVSEQP SYPGDIELEQ KIEAINRWNS TVIVAAANKK 100
DGSIGGHIGT GAGAMTLYEV GFNHFWKAPN DEHAGDLIFY QGHLSPIVYA 150
RSFLEGRITA EQLENFRKQA FNGQNAVSSY PHPYLQPTYW QFPTVSMGLG 200
PLQAIYQARF MKYLEARGLA KTSDRKVWAF CGDGEMDEPE SIGSITRAGR 250
EGLDNLIFVV NCNLQRLDGL VNGNGNIVEE LADVFAGAGW NVIKVLWSSD 300
WDKLLQDPRG GKKLAQRLSE LNDGQFHTIK AHGGAECRRV VFSGDEDLEA 350
LAKDMTDDDI QALRRGGHDP LKIYAAYKKA VENPNGRPTL ILPMTVKGYG 400
LGEWGESKNI AHNVKKLDTD ALEHIKNRFN VPASKEDIEN YRLIKLDENS 450
PEMKYLHSKR KDLGGYIPKR LENKQALEIP SYKDFAKSLL DDSGDREFST 500
TTAFVRILSH LAKDKNLGKH IVPITVDESR TFGMEGLFRQ LGIYNPHGQQ 550
YVPEDKQQVM FYKESVDGQI LQEGINEQGG FCSWIAAATS YSVHKVPMIP 600
FMIYYSMFGF QRFGDLAWAA GDSMAKGFVI GGTSGRTTLN GEGLQHEDGH 650
SHIQAGLIPN CISYDPTYAY ELAVILGEGM KRMYVDGDHV YYYITVMNEN 700
YSHRAMPEGC EEGIIKGLYK LDEEKKPASK HVQLLGSGSI LREVEAAAKM 750
LKEEYGITSN VWSMTSANEL YREAKDVARA NMLHPTAEKK ESYIEKCFKN 800
EQGPVIASTD YIKLYTDQLR EFIPHAFVNL GTDGFGRSDT RAALRSFFEV 850
DRYHVVVASL YALYLDGKVE ASEVKAAIEK YNIDPERMAP FYS 893
Length:893
Mass (Da):100,152
Last modified:May 1, 2007 - v1
Checksum:iBC1FB41EF64DF391
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000608 Genomic DNA. Translation: ABO46680.1.
RefSeqiYP_001121800.1. NC_009257.1.

Genome annotation databases

EnsemblBacteriaiABO46680; ABO46680; FTW_0808.
GeneIDi4960340.
KEGGiftw:FTW_0808.
PATRICi17969016. VBIFraTul58433_0824.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000608 Genomic DNA. Translation: ABO46680.1 .
RefSeqi YP_001121800.1. NC_009257.1.

3D structure databases

ProteinModelPortali A4IXM8.
SMRi A4IXM8. Positions 57-891.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 418136.FTW_0808.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABO46680 ; ABO46680 ; FTW_0808 .
GeneIDi 4960340.
KEGGi ftw:FTW_0808.
PATRICi 17969016. VBIFraTul58433_0824.

Phylogenomic databases

eggNOGi COG2609.
HOGENOMi HOG000115215.
KOi K00163.
OMAi KGIYKLD.
OrthoDBi EOG6BW4TW.

Enzyme and pathway databases

BioCyci FTUL418136:GHXJ-770-MONOMER.

Family and domain databases

Gene3Di 3.40.50.920. 1 hit.
3.40.50.970. 2 hits.
InterProi IPR004660. 2-oxoA_DH_E1.
IPR029061. THDP-binding.
IPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR005474. Transketolase_N.
[Graphical view ]
Pfami PF00456. Transketolase_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000156. Pyruvate_dh_E1. 1 hit.
SUPFAMi SSF52518. SSF52518. 2 hits.
SSF52922. SSF52922. 1 hit.
TIGRFAMsi TIGR00759. aceE. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: WY96-3418Imported.

Entry informationi

Entry nameiA4IXM8_FRATW
AccessioniPrimary (citable) accession number: A4IXM8
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2007
Last sequence update: May 1, 2007
Last modified: June 11, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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