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A4IXM8

- A4IXM8_FRATW

UniProt

A4IXM8 - A4IXM8_FRATW

Protein

Pyruvate dehydrogenase E1 component

Gene

aceE

Organism
Francisella tularensis subsp. tularensis (strain WY96-3418)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (01 May 2007)
      Previous versions | rss
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    Functioni

    Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.UniRule annotation

    Catalytic activityi

    Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2.UniRule annotation

    Cofactori

    Thiamine pyrophosphate.UniRule annotation

    GO - Molecular functioni

    1. pyruvate dehydrogenase (acetyl-transferring) activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotationImported

    Keywords - Ligandi

    PyruvateUniRule annotationImported, Thiamine pyrophosphateUniRule annotation

    Enzyme and pathway databases

    BioCyciFTUL418136:GHXJ-770-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pyruvate dehydrogenase E1 componentUniRule annotation (EC:1.2.4.1UniRule annotation)
    Gene namesi
    Name:aceEImported
    Ordered Locus Names:FTW_0808Imported
    OrganismiFrancisella tularensis subsp. tularensis (strain WY96-3418)Imported
    Taxonomic identifieri418136 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella
    ProteomesiUP000002285: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi418136.FTW_0808.

    Structurei

    3D structure databases

    ProteinModelPortaliA4IXM8.
    SMRiA4IXM8. Positions 57-891.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiCOG2609.
    HOGENOMiHOG000115215.
    KOiK00163.
    OMAiKGIYKLD.
    OrthoDBiEOG6BW4TW.

    Family and domain databases

    Gene3Di3.40.50.920. 1 hit.
    3.40.50.970. 2 hits.
    InterProiIPR004660. 2-oxoA_DH_E1.
    IPR029061. THDP-binding.
    IPR009014. Transketo_C/Pyr-ferredox_oxred.
    IPR005474. Transketolase_N.
    [Graphical view]
    PfamiPF00456. Transketolase_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000156. Pyruvate_dh_E1. 1 hit.
    SUPFAMiSSF52518. SSF52518. 2 hits.
    SSF52922. SSF52922. 1 hit.
    TIGRFAMsiTIGR00759. aceE. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A4IXM8-1 [UniParc]FASTAAdd to Basket

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    MSDFTKDIDV LETQEWLEAF EDVIKREGAD RAKFLFEQLL AKGSELGIKS    50
    AYSTAKVKNY VNSIDVSEQP SYPGDIELEQ KIEAINRWNS TVIVAAANKK 100
    DGSIGGHIGT GAGAMTLYEV GFNHFWKAPN DEHAGDLIFY QGHLSPIVYA 150
    RSFLEGRITA EQLENFRKQA FNGQNAVSSY PHPYLQPTYW QFPTVSMGLG 200
    PLQAIYQARF MKYLEARGLA KTSDRKVWAF CGDGEMDEPE SIGSITRAGR 250
    EGLDNLIFVV NCNLQRLDGL VNGNGNIVEE LADVFAGAGW NVIKVLWSSD 300
    WDKLLQDPRG GKKLAQRLSE LNDGQFHTIK AHGGAECRRV VFSGDEDLEA 350
    LAKDMTDDDI QALRRGGHDP LKIYAAYKKA VENPNGRPTL ILPMTVKGYG 400
    LGEWGESKNI AHNVKKLDTD ALEHIKNRFN VPASKEDIEN YRLIKLDENS 450
    PEMKYLHSKR KDLGGYIPKR LENKQALEIP SYKDFAKSLL DDSGDREFST 500
    TTAFVRILSH LAKDKNLGKH IVPITVDESR TFGMEGLFRQ LGIYNPHGQQ 550
    YVPEDKQQVM FYKESVDGQI LQEGINEQGG FCSWIAAATS YSVHKVPMIP 600
    FMIYYSMFGF QRFGDLAWAA GDSMAKGFVI GGTSGRTTLN GEGLQHEDGH 650
    SHIQAGLIPN CISYDPTYAY ELAVILGEGM KRMYVDGDHV YYYITVMNEN 700
    YSHRAMPEGC EEGIIKGLYK LDEEKKPASK HVQLLGSGSI LREVEAAAKM 750
    LKEEYGITSN VWSMTSANEL YREAKDVARA NMLHPTAEKK ESYIEKCFKN 800
    EQGPVIASTD YIKLYTDQLR EFIPHAFVNL GTDGFGRSDT RAALRSFFEV 850
    DRYHVVVASL YALYLDGKVE ASEVKAAIEK YNIDPERMAP FYS 893
    Length:893
    Mass (Da):100,152
    Last modified:May 1, 2007 - v1
    Checksum:iBC1FB41EF64DF391
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000608 Genomic DNA. Translation: ABO46680.1.
    RefSeqiYP_001121800.1. NC_009257.1.

    Genome annotation databases

    EnsemblBacteriaiABO46680; ABO46680; FTW_0808.
    GeneIDi4960340.
    KEGGiftw:FTW_0808.
    PATRICi17969016. VBIFraTul58433_0824.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000608 Genomic DNA. Translation: ABO46680.1 .
    RefSeqi YP_001121800.1. NC_009257.1.

    3D structure databases

    ProteinModelPortali A4IXM8.
    SMRi A4IXM8. Positions 57-891.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 418136.FTW_0808.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABO46680 ; ABO46680 ; FTW_0808 .
    GeneIDi 4960340.
    KEGGi ftw:FTW_0808.
    PATRICi 17969016. VBIFraTul58433_0824.

    Phylogenomic databases

    eggNOGi COG2609.
    HOGENOMi HOG000115215.
    KOi K00163.
    OMAi KGIYKLD.
    OrthoDBi EOG6BW4TW.

    Enzyme and pathway databases

    BioCyci FTUL418136:GHXJ-770-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.920. 1 hit.
    3.40.50.970. 2 hits.
    InterProi IPR004660. 2-oxoA_DH_E1.
    IPR029061. THDP-binding.
    IPR009014. Transketo_C/Pyr-ferredox_oxred.
    IPR005474. Transketolase_N.
    [Graphical view ]
    Pfami PF00456. Transketolase_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000156. Pyruvate_dh_E1. 1 hit.
    SUPFAMi SSF52518. SSF52518. 2 hits.
    SSF52922. SSF52922. 1 hit.
    TIGRFAMsi TIGR00759. aceE. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: WY96-3418Imported.

    Entry informationi

    Entry nameiA4IXM8_FRATW
    AccessioniPrimary (citable) accession number: A4IXM8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 1, 2007
    Last sequence update: May 1, 2007
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3