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Protein

S-adenosylmethionine:tRNA ribosyltransferase-isomerase

Gene

queA

Organism
Francisella tularensis subsp. tularensis (strain WY96-3418)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + 7-aminomethyl-7-carbaguanosine(34) in tRNA = L-methionine + adenine + epoxyqueuosine(34) in tRNA.UniRule annotation

Pathwayi: tRNA-queuosine biosynthesis

This protein is involved in the pathway tRNA-queuosine biosynthesis, which is part of tRNA modification.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway tRNA-queuosine biosynthesis and in tRNA modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processQueuosine biosynthesis
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciFTUL418136:G1G8F-701-MONOMER
UniPathwayiUPA00392

Names & Taxonomyi

Protein namesi
Recommended name:
S-adenosylmethionine:tRNA ribosyltransferase-isomeraseUniRule annotation (EC:2.4.99.17UniRule annotation)
Alternative name(s):
Queuosine biosynthesis protein QueAUniRule annotation
Gene namesi
Name:queAUniRule annotation
Ordered Locus Names:FTW_0731
OrganismiFrancisella tularensis subsp. tularensis (strain WY96-3418)
Taxonomic identifieri418136 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000713391 – 338S-adenosylmethionine:tRNA ribosyltransferase-isomeraseAdd BLAST338

Interactioni

Subunit structurei

Monomer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA4IXG2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the QueA family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000004402
KOiK07568
OMAiYSYGDGM

Family and domain databases

HAMAPiMF_00113 QueA, 1 hit
InterProiView protein in InterPro
IPR003699 QueA
IPR036100 QueA_sf
PANTHERiPTHR30307 PTHR30307, 1 hit
PfamiView protein in Pfam
PF02547 Queuosine_synth, 1 hit
SUPFAMiSSF111337 SSF111337, 1 hit
TIGRFAMsiTIGR00113 queA, 1 hit

Sequencei

Sequence statusi: Complete.

A4IXG2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTDDFDYKL PEELIASYPL ENRDASRLLK LNKQTGEIAD YKFTDFIDFI
60 70 80 90 100
NPGDLLVFNN SKVMLARLYG SKTTGAKLEY LIERIKNPKL FETHIKANRS
110 120 130 140 150
PAIGSEIYVE DTLAKVLDKD GGMYLLEIQG DKDIYQLMEE FGHIPLPPYM
160 170 180 190 200
KRDDEEFDAE RYQTVYAQDL GSVAAPTAGL HFSKELMQQI KDKGVDIAYI
210 220 230 240 250
TLHVGSGTFK PVQVDDVESH KMHAEVISVP VEVCQKIRQT KENGGRVIAI
260 270 280 290 300
GTTSVRSLET AGQNGQIEPY QGETDIFLYP GKKFNVVDAM ITNFHLPKST
310 320 330
LIMLVSAFAD KEKIIKAYEH AIAERYRFFS YGDAMFIF
Length:338
Mass (Da):38,312
Last modified:May 1, 2007 - v1
Checksum:iC51662CA8F3F6D37
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000608 Genomic DNA Translation: ABO46614.1
RefSeqiWP_003025806.1, NC_009257.1

Genome annotation databases

EnsemblBacteriaiABO46614; ABO46614; FTW_0731
KEGGiftw:FTW_0731

Similar proteinsi

Entry informationi

Entry nameiQUEA_FRATW
AccessioniPrimary (citable) accession number: A4IXG2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: May 1, 2007
Last modified: April 25, 2018
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health