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A4IWI7

- UNG_FRATW

UniProt

A4IWI7 - UNG_FRATW

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Protein
Uracil-DNA glycosylase
Gene
ung, FTW_0348
Organism
Francisella tularensis subsp. tularensis (strain WY96-3418)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine By similarity.UniRule annotation

Catalytic activityi

Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei60 – 601Proton acceptor By similarity

GO - Molecular functioni

  1. uracil DNA N-glycosylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. base-excision repair Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

DNA damage, DNA repair

Enzyme and pathway databases

BioCyciFTUL418136:GHXJ-321-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Uracil-DNA glycosylase (EC:3.2.2.27)
Short name:
UDG
Gene namesi
Name:ung
Ordered Locus Names:FTW_0348
OrganismiFrancisella tularensis subsp. tularensis (strain WY96-3418)
Taxonomic identifieri418136 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella
ProteomesiUP000002285: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 220220Uracil-DNA glycosylaseUniRule annotation
PRO_1000009893Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi418136.FTW_0348.

Structurei

3D structure databases

ProteinModelPortaliA4IWI7.
SMRiA4IWI7. Positions 2-216.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0692.
HOGENOMiHOG000229528.
KOiK03648.
OMAiWARQGVM.
OrthoDBiEOG6MSS63.

Family and domain databases

Gene3Di3.40.470.10. 1 hit.
HAMAPiMF_00148. UDG.
InterProiIPR018085. Ura-DNA_Glyclase_AS.
IPR002043. Ura_DNA_glycsylse.
IPR005122. Uracil-DNA_glycosylase-like.
[Graphical view]
PANTHERiPTHR11264. PTHR11264. 1 hit.
PfamiPF03167. UDG. 1 hit.
[Graphical view]
SMARTiSM00986. UDG. 1 hit.
[Graphical view]
SUPFAMiSSF52141. SSF52141. 1 hit.
TIGRFAMsiTIGR00628. ung. 1 hit.
PROSITEiPS00130. U_DNA_GLYCOSYLASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4IWI7-1 [UniParc]FASTAAdd to Basket

« Hide

MTWSDILAEE KQKPYFKQIL DFLACESAKG KVIFPTKENI FNAFKYTELD    50
NLKVVILGQD PYHNYNQAHG LAFSVQKGVD IPPSLQNIYK ELARSIPEFK 100
TPNHGYLVDW AKQGVFLLNT TLTVEAHKAN SHKDIGWETF TDTVINKISE 150
NKHNVVFMLW GSHARKKKVL IDSSRHLILE STHPSPLSAH RGFLGCNHFV 200
DCNKYLIEKK DQKIDWNLLC 220
Length:220
Mass (Da):25,298
Last modified:May 1, 2007 - v1
Checksum:i35DDC501CA0A1AF7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000608 Genomic DNA. Translation: ABO46289.1.
RefSeqiYP_001121409.1. NC_009257.1.

Genome annotation databases

EnsemblBacteriaiABO46289; ABO46289; FTW_0348.
GeneIDi4960408.
KEGGiftw:FTW_0348.
PATRICi17968018. VBIFraTul58433_0353.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000608 Genomic DNA. Translation: ABO46289.1 .
RefSeqi YP_001121409.1. NC_009257.1.

3D structure databases

ProteinModelPortali A4IWI7.
SMRi A4IWI7. Positions 2-216.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 418136.FTW_0348.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABO46289 ; ABO46289 ; FTW_0348 .
GeneIDi 4960408.
KEGGi ftw:FTW_0348.
PATRICi 17968018. VBIFraTul58433_0353.

Phylogenomic databases

eggNOGi COG0692.
HOGENOMi HOG000229528.
KOi K03648.
OMAi WARQGVM.
OrthoDBi EOG6MSS63.

Enzyme and pathway databases

BioCyci FTUL418136:GHXJ-321-MONOMER.

Family and domain databases

Gene3Di 3.40.470.10. 1 hit.
HAMAPi MF_00148. UDG.
InterProi IPR018085. Ura-DNA_Glyclase_AS.
IPR002043. Ura_DNA_glycsylse.
IPR005122. Uracil-DNA_glycosylase-like.
[Graphical view ]
PANTHERi PTHR11264. PTHR11264. 1 hit.
Pfami PF03167. UDG. 1 hit.
[Graphical view ]
SMARTi SM00986. UDG. 1 hit.
[Graphical view ]
SUPFAMi SSF52141. SSF52141. 1 hit.
TIGRFAMsi TIGR00628. ung. 1 hit.
PROSITEi PS00130. U_DNA_GLYCOSYLASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: WY96-3418.

Entry informationi

Entry nameiUNG_FRATW
AccessioniPrimary (citable) accession number: A4IWI7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 1, 2007
Last modified: May 14, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi