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A4IWI7

- UNG_FRATW

UniProt

A4IWI7 - UNG_FRATW

Protein

Uracil-DNA glycosylase

Gene

ung

Organism
Francisella tularensis subsp. tularensis (strain WY96-3418)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (01 May 2007)
      Previous versions | rss
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    Functioni

    Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.UniRule annotation

    Catalytic activityi

    Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei60 – 601Proton acceptorUniRule annotation

    GO - Molecular functioni

    1. uracil DNA N-glycosylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. base-excision repair Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Keywords - Biological processi

    DNA damage, DNA repair

    Enzyme and pathway databases

    BioCyciFTUL418136:GHXJ-321-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Uracil-DNA glycosylaseUniRule annotation (EC:3.2.2.27UniRule annotation)
    Short name:
    UDGUniRule annotation
    Gene namesi
    Name:ungUniRule annotation
    Ordered Locus Names:FTW_0348
    OrganismiFrancisella tularensis subsp. tularensis (strain WY96-3418)
    Taxonomic identifieri418136 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella
    ProteomesiUP000002285: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 220220Uracil-DNA glycosylasePRO_1000009893Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi418136.FTW_0348.

    Structurei

    3D structure databases

    ProteinModelPortaliA4IWI7.
    SMRiA4IWI7. Positions 2-216.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the uracil-DNA glycosylase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0692.
    HOGENOMiHOG000229528.
    KOiK03648.
    OMAiWARQGVM.
    OrthoDBiEOG6MSS63.

    Family and domain databases

    Gene3Di3.40.470.10. 1 hit.
    HAMAPiMF_00148. UDG.
    InterProiIPR018085. Ura-DNA_Glyclase_AS.
    IPR002043. Ura_DNA_glycsylse.
    IPR005122. Uracil-DNA_glycosylase-like.
    [Graphical view]
    PANTHERiPTHR11264. PTHR11264. 1 hit.
    PfamiPF03167. UDG. 1 hit.
    [Graphical view]
    SMARTiSM00986. UDG. 1 hit.
    [Graphical view]
    SUPFAMiSSF52141. SSF52141. 1 hit.
    TIGRFAMsiTIGR00628. ung. 1 hit.
    PROSITEiPS00130. U_DNA_GLYCOSYLASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A4IWI7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTWSDILAEE KQKPYFKQIL DFLACESAKG KVIFPTKENI FNAFKYTELD    50
    NLKVVILGQD PYHNYNQAHG LAFSVQKGVD IPPSLQNIYK ELARSIPEFK 100
    TPNHGYLVDW AKQGVFLLNT TLTVEAHKAN SHKDIGWETF TDTVINKISE 150
    NKHNVVFMLW GSHARKKKVL IDSSRHLILE STHPSPLSAH RGFLGCNHFV 200
    DCNKYLIEKK DQKIDWNLLC 220
    Length:220
    Mass (Da):25,298
    Last modified:May 1, 2007 - v1
    Checksum:i35DDC501CA0A1AF7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000608 Genomic DNA. Translation: ABO46289.1.
    RefSeqiYP_001121409.1. NC_009257.1.

    Genome annotation databases

    EnsemblBacteriaiABO46289; ABO46289; FTW_0348.
    GeneIDi4960408.
    KEGGiftw:FTW_0348.
    PATRICi17968018. VBIFraTul58433_0353.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000608 Genomic DNA. Translation: ABO46289.1 .
    RefSeqi YP_001121409.1. NC_009257.1.

    3D structure databases

    ProteinModelPortali A4IWI7.
    SMRi A4IWI7. Positions 2-216.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 418136.FTW_0348.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABO46289 ; ABO46289 ; FTW_0348 .
    GeneIDi 4960408.
    KEGGi ftw:FTW_0348.
    PATRICi 17968018. VBIFraTul58433_0353.

    Phylogenomic databases

    eggNOGi COG0692.
    HOGENOMi HOG000229528.
    KOi K03648.
    OMAi WARQGVM.
    OrthoDBi EOG6MSS63.

    Enzyme and pathway databases

    BioCyci FTUL418136:GHXJ-321-MONOMER.

    Family and domain databases

    Gene3Di 3.40.470.10. 1 hit.
    HAMAPi MF_00148. UDG.
    InterProi IPR018085. Ura-DNA_Glyclase_AS.
    IPR002043. Ura_DNA_glycsylse.
    IPR005122. Uracil-DNA_glycosylase-like.
    [Graphical view ]
    PANTHERi PTHR11264. PTHR11264. 1 hit.
    Pfami PF03167. UDG. 1 hit.
    [Graphical view ]
    SMARTi SM00986. UDG. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52141. SSF52141. 1 hit.
    TIGRFAMsi TIGR00628. ung. 1 hit.
    PROSITEi PS00130. U_DNA_GLYCOSYLASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: WY96-3418.

    Entry informationi

    Entry nameiUNG_FRATW
    AccessioniPrimary (citable) accession number: A4IWI7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: May 1, 2007
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3