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A4IWI7

- UNG_FRATW

UniProt

A4IWI7 - UNG_FRATW

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Protein

Uracil-DNA glycosylase

Gene

ung

Organism
Francisella tularensis subsp. tularensis (strain WY96-3418)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.UniRule annotation

Catalytic activityi

Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei60 – 601Proton acceptorUniRule annotation

GO - Molecular functioni

  1. uracil DNA N-glycosylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. base-excision repair Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

DNA damage, DNA repair

Enzyme and pathway databases

BioCyciFTUL418136:GHXJ-321-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Uracil-DNA glycosylaseUniRule annotation (EC:3.2.2.27UniRule annotation)
Short name:
UDGUniRule annotation
Gene namesi
Name:ungUniRule annotation
Ordered Locus Names:FTW_0348
OrganismiFrancisella tularensis subsp. tularensis (strain WY96-3418)
Taxonomic identifieri418136 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesFrancisellaceaeFrancisella
ProteomesiUP000002285: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 220220Uracil-DNA glycosylasePRO_1000009893Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi418136.FTW_0348.

Structurei

3D structure databases

ProteinModelPortaliA4IWI7.
SMRiA4IWI7. Positions 2-216.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the uracil-DNA glycosylase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0692.
HOGENOMiHOG000229528.
KOiK03648.
OMAiWARQGVM.
OrthoDBiEOG6MSS63.

Family and domain databases

Gene3Di3.40.470.10. 1 hit.
HAMAPiMF_00148. UDG.
InterProiIPR018085. Ura-DNA_Glyclase_AS.
IPR002043. Ura_DNA_glycsylse.
IPR005122. Uracil-DNA_glycosylase-like.
[Graphical view]
PANTHERiPTHR11264. PTHR11264. 1 hit.
PfamiPF03167. UDG. 1 hit.
[Graphical view]
SMARTiSM00986. UDG. 1 hit.
[Graphical view]
SUPFAMiSSF52141. SSF52141. 1 hit.
TIGRFAMsiTIGR00628. ung. 1 hit.
PROSITEiPS00130. U_DNA_GLYCOSYLASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4IWI7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTWSDILAEE KQKPYFKQIL DFLACESAKG KVIFPTKENI FNAFKYTELD
60 70 80 90 100
NLKVVILGQD PYHNYNQAHG LAFSVQKGVD IPPSLQNIYK ELARSIPEFK
110 120 130 140 150
TPNHGYLVDW AKQGVFLLNT TLTVEAHKAN SHKDIGWETF TDTVINKISE
160 170 180 190 200
NKHNVVFMLW GSHARKKKVL IDSSRHLILE STHPSPLSAH RGFLGCNHFV
210 220
DCNKYLIEKK DQKIDWNLLC
Length:220
Mass (Da):25,298
Last modified:May 1, 2007 - v1
Checksum:i35DDC501CA0A1AF7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000608 Genomic DNA. Translation: ABO46289.1.
RefSeqiYP_001121409.1. NC_009257.1.

Genome annotation databases

EnsemblBacteriaiABO46289; ABO46289; FTW_0348.
GeneIDi4960408.
KEGGiftw:FTW_0348.
PATRICi17968018. VBIFraTul58433_0353.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000608 Genomic DNA. Translation: ABO46289.1 .
RefSeqi YP_001121409.1. NC_009257.1.

3D structure databases

ProteinModelPortali A4IWI7.
SMRi A4IWI7. Positions 2-216.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 418136.FTW_0348.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABO46289 ; ABO46289 ; FTW_0348 .
GeneIDi 4960408.
KEGGi ftw:FTW_0348.
PATRICi 17968018. VBIFraTul58433_0353.

Phylogenomic databases

eggNOGi COG0692.
HOGENOMi HOG000229528.
KOi K03648.
OMAi WARQGVM.
OrthoDBi EOG6MSS63.

Enzyme and pathway databases

BioCyci FTUL418136:GHXJ-321-MONOMER.

Family and domain databases

Gene3Di 3.40.470.10. 1 hit.
HAMAPi MF_00148. UDG.
InterProi IPR018085. Ura-DNA_Glyclase_AS.
IPR002043. Ura_DNA_glycsylse.
IPR005122. Uracil-DNA_glycosylase-like.
[Graphical view ]
PANTHERi PTHR11264. PTHR11264. 1 hit.
Pfami PF03167. UDG. 1 hit.
[Graphical view ]
SMARTi SM00986. UDG. 1 hit.
[Graphical view ]
SUPFAMi SSF52141. SSF52141. 1 hit.
TIGRFAMsi TIGR00628. ung. 1 hit.
PROSITEi PS00130. U_DNA_GLYCOSYLASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: WY96-3418.

Entry informationi

Entry nameiUNG_FRATW
AccessioniPrimary (citable) accession number: A4IWI7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 1, 2007
Last modified: October 29, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3