A4IT60 (KYNB_GEOTN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Kynurenine formamidase
Short name=KFA
EC=3.5.1.9

Alternative name(s):
N-formylkynurenine formamidase

Gene names

Name:	kynB
Ordered Locus Names:	GTNG_3169

Organism

Geobacillus thermodenitrificans (strain NG80-2) [Complete proteome] [HAMAP]

Taxonomic identifier

420246 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Geobacillus

Protein attributes

Sequence length	209 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine By similarity.
Catalytic activity	N-formyl-L-kynurenine + H2O = formate + L-kynurenine.
Pathway	Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 2/2.
Sequence similarities	Belongs to the kynB family.

Ontologies

Keywords
Biological process	Tryptophan catabolism
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	anthranilate metabolic process Inferred from sequence or structural similarity. Source: UniProtKB tryptophan catabolic process to kynurenine Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	arylformamidase activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 209	209	Kynurenine formamidase		PRO_0000362124

Sequences

	Sequence		Length	Mass (Da)
	A4IT60-1 [UniParc]. Last modified May 1, 2007. Version 1. Checksum: 26F88C86A754B965	FASTA	209	23,327
	10 20 30 40 50 60 MMNPWIDISQ RLDEHIPVWP GDTPFSYRTR WNKAESGSVN VGQITMSTHT GTHIDAPFHF 70 80 90 100 110 120 DNEGKRVIDL DLNIYIGPAR VIHLSNPKKI GIDELQTIDL HGVTRLLIYT GAWTNRTTFP 130 140 150 160 170 180 ETIPYIDPPL APYLKKYGVR LIGIDLPSVD PLTSKQLPAH HELHRCGIHI LEGLVLDHVS 190 200 PGDYELAALP LPLVNADGSP VRAALRKMG

References

[1]

"Genome and proteome of long-chain alkane degrading Geobacillus thermodenitrificans NG80-2 isolated from a deep-subsurface oil reservoir." Feng L., Wang W., Cheng J., Ren Y., Zhao G., Gao C., Tang Y., Liu X., Han W., Peng X., Liu R., Wang L. Proc. Natl. Acad. Sci. U.S.A. 104:5602-5607(2007) [PubMed: 17372208] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000557 Genomic DNA. Translation: ABO68514.1.
RefSeq	YP_001127259.1.
3D structure databases
ProteinModelPortal	A4IT60.
SMR	A4IT60. Positions 4-206.
ModBase	Search...
Protein-protein interaction databases
STRING	A4IT60.
Genome annotation databases
GeneID	4968095.
GenomeReviews	Gene locus GTNG_3169 in contig CP000557_GR.
KEGG	gtn:GTNG_3169.
NMPDR	fig|420246.5.peg.3032.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1878.
HOGENOM	HBG686791.
OMA	FHFDNDG.
ProtClustDB	CLSK904617.
Enzyme and pathway databases
BioCyc	GTHE420246:GTNG_3169-MONOMER.
Family and domain databases
InterPro	IPR017484. Arylformamidase. IPR007325. Cyclase. [Graphical view]
Pfam	PF04199. Cyclase. 1 hit. [Graphical view]
TIGRFAMs	TIGR03035. trp_arylform. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KYNB_GEOTN

Accession

Primary (citable) accession number: A4IT60

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 10, 2009
Last sequence update:	May 1, 2007
Last modified:	August 10, 2010
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)