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Protein

Kynurenine formamidase

Gene

kynB

Organism
Geobacillus thermodenitrificans (strain NG80-2)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation.UniRule annotation

Catalytic activityi

N-formyl-L-kynurenine + H2O = formate + L-kynurenine.UniRule annotation

Pathwayi: L-tryptophan degradation via kynurenine pathway

This protein is involved in step 2 of the subpathway that synthesizes L-kynurenine from L-tryptophan.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Tryptophan 2,3-dioxygenase (kynA)
  2. Kynurenine formamidase (kynB)
This subpathway is part of the pathway L-tryptophan degradation via kynurenine pathway, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-kynurenine from L-tryptophan, the pathway L-tryptophan degradation via kynurenine pathway and in Amino-acid degradation.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processTryptophan catabolism

Enzyme and pathway databases

UniPathwayiUPA00333; UER00454

Names & Taxonomyi

Protein namesi
Recommended name:
Kynurenine formamidaseUniRule annotation (EC:3.5.1.9UniRule annotation)
Short name:
KFAUniRule annotation
Short name:
KFaseUniRule annotation
Alternative name(s):
ArylformamidaseUniRule annotation
N-formylkynurenine formamidaseUniRule annotation
Short name:
FKFUniRule annotation
Gene namesi
Name:kynBUniRule annotation
Ordered Locus Names:GTNG_3169
OrganismiGeobacillus thermodenitrificans (strain NG80-2)
Taxonomic identifieri420246 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus
Proteomesi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003621241 – 209Kynurenine formamidaseAdd BLAST209

Interactioni

Protein-protein interaction databases

STRINGi420246.GTNG_3169

Structurei

3D structure databases

ProteinModelPortaliA4IT60
SMRiA4IT60
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Cyclase 1 superfamily. KynB family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4106IPI Bacteria
COG1878 LUCA
HOGENOMiHOG000219455
KOiK07130
OMAiPSWESDG
OrthoDBiPOG091H0N8N

Family and domain databases

Gene3Di3.50.30.50, 1 hit
HAMAPiMF_01969 KynB, 1 hit
InterProiView protein in InterPro
IPR007325 KFase
IPR037175 KFase_sf
IPR017484 Kynurenine_formamidase_bac
PfamiView protein in Pfam
PF04199 Cyclase, 1 hit
SUPFAMiSSF102198 SSF102198, 1 hit
TIGRFAMsiTIGR03035 trp_arylform, 1 hit

Sequencei

Sequence statusi: Complete.

A4IT60-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMNPWIDISQ RLDEHIPVWP GDTPFSYRTR WNKAESGSVN VGQITMSTHT
60 70 80 90 100
GTHIDAPFHF DNEGKRVIDL DLNIYIGPAR VIHLSNPKKI GIDELQTIDL
110 120 130 140 150
HGVTRLLIYT GAWTNRTTFP ETIPYIDPPL APYLKKYGVR LIGIDLPSVD
160 170 180 190 200
PLTSKQLPAH HELHRCGIHI LEGLVLDHVS PGDYELAALP LPLVNADGSP

VRAALRKMG
Length:209
Mass (Da):23,327
Last modified:May 1, 2007 - v1
Checksum:i26F88C86A754B965
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000557 Genomic DNA Translation: ABO68514.1

Genome annotation databases

EnsemblBacteriaiABO68514; ABO68514; GTNG_3169
KEGGigtn:GTNG_3169

Similar proteinsi

Entry informationi

Entry nameiKYNB_GEOTN
AccessioniPrimary (citable) accession number: A4IT60
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: May 1, 2007
Last modified: April 25, 2018
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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