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A4ISN1 (A4ISN1_GEOTN) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesSubmitted name:
Dihydrodipicolinate synthase EMBL ABO68335.1
Gene names
Name:hpaD EMBL ABO68335.1
Ordered Locus Names:GTNG_2990
OrganismGeobacillus thermodenitrificans (strain NG80-2) [Complete proteome] [HAMAP]
Taxonomic identifier420246 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Geobacillus

Protein attributes

Sequence length309 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

L-aspartate 4-semialdehyde + pyruvate = dihydrodipicolinate + 2 H2O. SAAS SAAS005263

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 3/4. SAAS SAAS005263

Subunit structure

Homotetramer By similarity. SAAS SAAS005263

Subcellular location

Cytoplasm By similarity SAAS SAAS005263.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Diaminopimelate biosynthesis SAAS SAAS005263
Lysine biosynthesis SAAS SAAS005263
   Cellular componentCytoplasm SAAS SAAS005263
   LigandSchiff base SAAS SAAS005263
   Molecular functionLyase SAAS SAAS005263
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processdiaminopimelate biosynthetic process

Inferred from electronic annotation. Source: HAMAP

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functiondihydrodipicolinate synthase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
A4ISN1 [UniParc].

Last modified May 1, 2007. Version 1.
Checksum: F30C253A75543B0B

FASTA30933,962
        10         20         30         40         50         60 
MAYREVKERL RGSIAPVVTP FDEEGNVDLT TLTSLIDWHI KSGTHGISVT GTSGEPSSLT 

        70         80         90        100        110        120 
LDERKQVMET AKKAVAGRVP FVPGTGSTNH AETIELTKFA QEIGADAAMV IVPYYNRPSQ 

       130        140        150        160        170        180 
QALYKHFKAV AESVDIPIIV YNIPGRTAVN LEVKTLARLV EDCPNIIGVK ESNKDFEHVN 

       190        200        210        220        230        240 
RVLWHCGRDF LLFSGIELLC YPMLAIGGAG SISATANVVP QKVAELHDAW FDGDVKRAQD 

       250        260        270        280        290        300 
LHFELMELND VLFIETNPGP VKAALGMLGK ITPKLRLPLD LPSEEHQEQI RRTLVKYGLL 


TEAAQQPAK

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References

[1]"Genome and proteome of long-chain alkane degrading Geobacillus thermodenitrificans NG80-2 isolated from a deep-subsurface oil reservoir."
Feng L., Wang W., Cheng J., Ren Y., Zhao G., Gao C., Tang Y., Liu X., Han W., Peng X., Liu R., Wang L.
Proc. Natl. Acad. Sci. U.S.A. 104:5602-5607(2007) [PubMed: 17372208] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000557 Genomic DNA. Translation: ABO68335.1.
RefSeqYP_001127080.1. NC_009328.1.

3D structure databases

ProteinModelPortalA4ISN1.
ModBaseSearch...

Protein-protein interaction databases

STRINGA4ISN1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4967916.
GenomeReviewsGene locus GTNG_2990 in contig CP000557_GR.
KEGGgtn:GTNG_2990.
NMPDRfig|420246.5.peg.2868.
PATRIC21982609. VBIGeoThe136879_3148.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0329.
HOGENOMHBG358848.
OMAGSTNHAE.
PhylomeDBA4ISN1.
ProtClustDBCLSK904759.

Family and domain databases

InterProIPR013785. Aldolase_TIM.
IPR002220. Dihydrodipicolinate_synth-like.
IPR020625. Dihydrodipicolinate_synth_AS.
IPR005263. Dihydrodipicolinate_synth_DapA.
IPR012691. HpaI_NOT_DapA.
[Graphical view]
Gene3DG3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KOK01714.
PANTHERPTHR12128. DHDPS. 1 hit.
PfamPF00701. DHDPS. 1 hit.
[Graphical view]
PIRSFPIRSF001365. DHDPS. 1 hit.
PRINTSPR00146. DHPICSNTHASE.
TIGRFAMsTIGR00674. DapA. 1 hit.
TIGR02313. HpaI-NOT-DapA. 1 hit.
PROSITEPS00666. DHDPS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA4ISN1_GEOTN
AccessionPrimary (citable) accession number: A4ISN1
Entry history
Integrated into UniProtKB/TrEMBL: May 1, 2007
Last sequence update: May 1, 2007
Last modified: December 14, 2011
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info