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A4ISF3

- A4ISF3_GEOTN

UniProt

A4ISF3 - A4ISF3_GEOTN

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Protein
Homoserine kinase
Gene
thrB, GTNG_2912
Organism
Geobacillus thermodenitrificans (strain NG80-2)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate By similarity.UniRule annotationSAAS annotations

Catalytic activityi

ATP + L-homoserine = ADP + O-phospho-L-homoserine.UniRule annotationSAAS annotations

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi90 – 10011ATP By similarityUniRule annotation
Add
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. homoserine kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. threonine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotationsImported, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Threonine biosynthesisUniRule annotationSAAS annotations

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, Nucleotide-binding

Enzyme and pathway databases

BioCyciGTHE420246:GIXT-3007-MONOMER.
UniPathwayiUPA00050; UER00064.

Names & Taxonomyi

Protein namesi
Recommended name:
Homoserine kinaseUniRule annotation (EC:2.7.1.39UniRule annotation)
Short name:
HKUniRule annotation
Short name:
HSKUniRule annotation
Gene namesi
Name:thrBUniRule annotation
Ordered Locus Names:GTNG_2912Imported
OrganismiGeobacillus thermodenitrificans (strain NG80-2)Imported
Taxonomic identifieri420246 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus
ProteomesiUP000001578: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

Interactioni

Protein-protein interaction databases

STRINGi420246.GTNG_2912.

Structurei

3D structure databases

ProteinModelPortaliA4ISF3.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0083.
HOGENOMiHOG000247200.
KOiK00872.
OMAiMQDRLHQ.
OrthoDBiEOG6DG2WK.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.30.70.890. 1 hit.
HAMAPiMF_00384. Homoser_kinase.
InterProiIPR013750. GHMP_kinase_C_dom.
IPR006204. GHMP_kinase_N_dom.
IPR006203. GHMP_knse_ATP-bd_CS.
IPR000870. Homoserine_kinase.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PfamiPF08544. GHMP_kinases_C. 1 hit.
PF00288. GHMP_kinases_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000676. Homoser_kin. 1 hit.
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55060. SSF55060. 1 hit.
TIGRFAMsiTIGR00191. thrB. 1 hit.
PROSITEiPS00627. GHMP_KINASES_ATP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4ISF3-1 [UniParc]FASTAAdd to Basket

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MKEDEMLKIV VPGSTANLGP GFDSVGLAVS RYLTLDVRLA RTWSFTPKTA    50
EVSDIPRGTD NLVYKVANET AKAHGRQLPS CEVDVYSDIP FTRGLGSSAA 100
AVVAGIELAD ALLELGLTRE QKMELATRYE GHPDNVGASL YGGLVIGCYR 150
EAGVDVVHVP ELAIELVAII PAYELETKKA RGQLPEQWMR QQAVEASAIS 200
NVLVAALLTK NWKLAGRMMA ADLFHQPYRK SLVPELERAQ ALAEEYEAIG 250
AALSGAGPTV LVFAEPGKGE QLERQLRPHF PACEVTWLAI EPHGSRVYKL 300
ALEA 304
Length:304
Mass (Da):32,946
Last modified:May 1, 2007 - v1
Checksum:i4E8079118E217B6D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000557 Genomic DNA. Translation: ABO68257.1.
RefSeqiYP_001127002.1. NC_009328.1.

Genome annotation databases

EnsemblBacteriaiABO68257; ABO68257; GTNG_2912.
GeneIDi4967838.
KEGGigtn:GTNG_2912.
PATRICi21982447. VBIGeoThe136879_3067.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000557 Genomic DNA. Translation: ABO68257.1 .
RefSeqi YP_001127002.1. NC_009328.1.

3D structure databases

ProteinModelPortali A4ISF3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 420246.GTNG_2912.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABO68257 ; ABO68257 ; GTNG_2912 .
GeneIDi 4967838.
KEGGi gtn:GTNG_2912.
PATRICi 21982447. VBIGeoThe136879_3067.

Phylogenomic databases

eggNOGi COG0083.
HOGENOMi HOG000247200.
KOi K00872.
OMAi MQDRLHQ.
OrthoDBi EOG6DG2WK.

Enzyme and pathway databases

UniPathwayi UPA00050 ; UER00064 .
BioCyci GTHE420246:GIXT-3007-MONOMER.

Family and domain databases

Gene3Di 3.30.230.10. 1 hit.
3.30.70.890. 1 hit.
HAMAPi MF_00384. Homoser_kinase.
InterProi IPR013750. GHMP_kinase_C_dom.
IPR006204. GHMP_kinase_N_dom.
IPR006203. GHMP_knse_ATP-bd_CS.
IPR000870. Homoserine_kinase.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view ]
Pfami PF08544. GHMP_kinases_C. 1 hit.
PF00288. GHMP_kinases_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000676. Homoser_kin. 1 hit.
SUPFAMi SSF54211. SSF54211. 1 hit.
SSF55060. SSF55060. 1 hit.
TIGRFAMsi TIGR00191. thrB. 1 hit.
PROSITEi PS00627. GHMP_KINASES_ATP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome and proteome of long-chain alkane degrading Geobacillus thermodenitrificans NG80-2 isolated from a deep-subsurface oil reservoir."
    Feng L., Wang W., Cheng J., Ren Y., Zhao G., Gao C., Tang Y., Liu X., Han W., Peng X., Liu R., Wang L.
    Proc. Natl. Acad. Sci. U.S.A. 104:5602-5607(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NG80-2Imported.

Entry informationi

Entry nameiA4ISF3_GEOTN
AccessioniPrimary (citable) accession number: A4ISF3
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2007
Last sequence update: May 1, 2007
Last modified: June 11, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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