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A4ISF3

- A4ISF3_GEOTN

UniProt

A4ISF3 - A4ISF3_GEOTN

Protein

Homoserine kinase

Gene

thrB

Organism
Geobacillus thermodenitrificans (strain NG80-2)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (01 May 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.UniRule annotationSAAS annotation

    Catalytic activityi

    ATP + L-homoserine = ADP + O-phospho-L-homoserine.UniRule annotationSAAS annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi90 – 10011ATPUniRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. homoserine kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. threonine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    KinaseUniRule annotationSAAS annotationImported, Transferase

    Keywords - Biological processi

    Amino-acid biosynthesis, Threonine biosynthesisUniRule annotationSAAS annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciGTHE420246:GIXT-3007-MONOMER.
    UniPathwayiUPA00050; UER00064.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homoserine kinaseUniRule annotation (EC:2.7.1.39UniRule annotation)
    Short name:
    HKUniRule annotation
    Short name:
    HSKUniRule annotation
    Gene namesi
    Name:thrBUniRule annotation
    Ordered Locus Names:GTNG_2912Imported
    OrganismiGeobacillus thermodenitrificans (strain NG80-2)Imported
    Taxonomic identifieri420246 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus
    ProteomesiUP000001578: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    Interactioni

    Protein-protein interaction databases

    STRINGi420246.GTNG_2912.

    Structurei

    3D structure databases

    ProteinModelPortaliA4ISF3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GHMP kinase family. Homoserine kinase subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0083.
    HOGENOMiHOG000247200.
    KOiK00872.
    OMAiMQDRLHQ.
    OrthoDBiEOG6DG2WK.

    Family and domain databases

    Gene3Di3.30.230.10. 1 hit.
    3.30.70.890. 1 hit.
    HAMAPiMF_00384. Homoser_kinase.
    InterProiIPR013750. GHMP_kinase_C_dom.
    IPR006204. GHMP_kinase_N_dom.
    IPR006203. GHMP_knse_ATP-bd_CS.
    IPR000870. Homoserine_kinase.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
    [Graphical view]
    PfamiPF08544. GHMP_kinases_C. 1 hit.
    PF00288. GHMP_kinases_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000676. Homoser_kin. 1 hit.
    SUPFAMiSSF54211. SSF54211. 1 hit.
    SSF55060. SSF55060. 1 hit.
    TIGRFAMsiTIGR00191. thrB. 1 hit.
    PROSITEiPS00627. GHMP_KINASES_ATP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A4ISF3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKEDEMLKIV VPGSTANLGP GFDSVGLAVS RYLTLDVRLA RTWSFTPKTA    50
    EVSDIPRGTD NLVYKVANET AKAHGRQLPS CEVDVYSDIP FTRGLGSSAA 100
    AVVAGIELAD ALLELGLTRE QKMELATRYE GHPDNVGASL YGGLVIGCYR 150
    EAGVDVVHVP ELAIELVAII PAYELETKKA RGQLPEQWMR QQAVEASAIS 200
    NVLVAALLTK NWKLAGRMMA ADLFHQPYRK SLVPELERAQ ALAEEYEAIG 250
    AALSGAGPTV LVFAEPGKGE QLERQLRPHF PACEVTWLAI EPHGSRVYKL 300
    ALEA 304
    Length:304
    Mass (Da):32,946
    Last modified:May 1, 2007 - v1
    Checksum:i4E8079118E217B6D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000557 Genomic DNA. Translation: ABO68257.1.
    RefSeqiYP_001127002.1. NC_009328.1.

    Genome annotation databases

    EnsemblBacteriaiABO68257; ABO68257; GTNG_2912.
    GeneIDi4967838.
    KEGGigtn:GTNG_2912.
    PATRICi21982447. VBIGeoThe136879_3067.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000557 Genomic DNA. Translation: ABO68257.1 .
    RefSeqi YP_001127002.1. NC_009328.1.

    3D structure databases

    ProteinModelPortali A4ISF3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 420246.GTNG_2912.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABO68257 ; ABO68257 ; GTNG_2912 .
    GeneIDi 4967838.
    KEGGi gtn:GTNG_2912.
    PATRICi 21982447. VBIGeoThe136879_3067.

    Phylogenomic databases

    eggNOGi COG0083.
    HOGENOMi HOG000247200.
    KOi K00872.
    OMAi MQDRLHQ.
    OrthoDBi EOG6DG2WK.

    Enzyme and pathway databases

    UniPathwayi UPA00050 ; UER00064 .
    BioCyci GTHE420246:GIXT-3007-MONOMER.

    Family and domain databases

    Gene3Di 3.30.230.10. 1 hit.
    3.30.70.890. 1 hit.
    HAMAPi MF_00384. Homoser_kinase.
    InterProi IPR013750. GHMP_kinase_C_dom.
    IPR006204. GHMP_kinase_N_dom.
    IPR006203. GHMP_knse_ATP-bd_CS.
    IPR000870. Homoserine_kinase.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
    [Graphical view ]
    Pfami PF08544. GHMP_kinases_C. 1 hit.
    PF00288. GHMP_kinases_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000676. Homoser_kin. 1 hit.
    SUPFAMi SSF54211. SSF54211. 1 hit.
    SSF55060. SSF55060. 1 hit.
    TIGRFAMsi TIGR00191. thrB. 1 hit.
    PROSITEi PS00627. GHMP_KINASES_ATP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome and proteome of long-chain alkane degrading Geobacillus thermodenitrificans NG80-2 isolated from a deep-subsurface oil reservoir."
      Feng L., Wang W., Cheng J., Ren Y., Zhao G., Gao C., Tang Y., Liu X., Han W., Peng X., Liu R., Wang L.
      Proc. Natl. Acad. Sci. U.S.A. 104:5602-5607(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NG80-2Imported.

    Entry informationi

    Entry nameiA4ISF3_GEOTN
    AccessioniPrimary (citable) accession number: A4ISF3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 1, 2007
    Last sequence update: May 1, 2007
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3