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A4ISF3

- A4ISF3_GEOTN

UniProt

A4ISF3 - A4ISF3_GEOTN

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Protein

Homoserine kinase

Gene

thrB

Organism
Geobacillus thermodenitrificans (strain NG80-2)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.UniRule annotationSAAS annotation

Catalytic activityi

ATP + L-homoserine = ADP + O-phospho-L-homoserine.UniRule annotationSAAS annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi90 – 10011ATPUniRule annotationAdd
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. homoserine kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. threonine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotation, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Threonine biosynthesisUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciGTHE420246:GIXT-3007-MONOMER.
UniPathwayiUPA00050; UER00064.

Names & Taxonomyi

Protein namesi
Recommended name:
Homoserine kinaseUniRule annotation (EC:2.7.1.39UniRule annotation)
Short name:
HKUniRule annotation
Short name:
HSKUniRule annotation
Gene namesi
Name:thrBUniRule annotation
Ordered Locus Names:GTNG_2912Imported
OrganismiGeobacillus thermodenitrificans (strain NG80-2)Imported
Taxonomic identifieri420246 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus
ProteomesiUP000001578: Chromosome

Subcellular locationi

Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi420246.GTNG_2912.

Structurei

3D structure databases

ProteinModelPortaliA4ISF3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GHMP kinase family. Homoserine kinase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0083.
HOGENOMiHOG000247200.
KOiK00872.
OMAiMQDRLHQ.
OrthoDBiEOG6DG2WK.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.30.70.890. 1 hit.
HAMAPiMF_00384. Homoser_kinase.
InterProiIPR013750. GHMP_kinase_C_dom.
IPR006204. GHMP_kinase_N_dom.
IPR006203. GHMP_knse_ATP-bd_CS.
IPR000870. Homoserine_kinase.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PfamiPF08544. GHMP_kinases_C. 1 hit.
PF00288. GHMP_kinases_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000676. Homoser_kin. 1 hit.
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55060. SSF55060. 1 hit.
TIGRFAMsiTIGR00191. thrB. 1 hit.
PROSITEiPS00627. GHMP_KINASES_ATP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4ISF3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKEDEMLKIV VPGSTANLGP GFDSVGLAVS RYLTLDVRLA RTWSFTPKTA
60 70 80 90 100
EVSDIPRGTD NLVYKVANET AKAHGRQLPS CEVDVYSDIP FTRGLGSSAA
110 120 130 140 150
AVVAGIELAD ALLELGLTRE QKMELATRYE GHPDNVGASL YGGLVIGCYR
160 170 180 190 200
EAGVDVVHVP ELAIELVAII PAYELETKKA RGQLPEQWMR QQAVEASAIS
210 220 230 240 250
NVLVAALLTK NWKLAGRMMA ADLFHQPYRK SLVPELERAQ ALAEEYEAIG
260 270 280 290 300
AALSGAGPTV LVFAEPGKGE QLERQLRPHF PACEVTWLAI EPHGSRVYKL

ALEA
Length:304
Mass (Da):32,946
Last modified:May 1, 2007 - v1
Checksum:i4E8079118E217B6D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000557 Genomic DNA. Translation: ABO68257.1.
RefSeqiWP_011888121.1. NC_009328.1.
YP_001127002.1. NC_009328.1.

Genome annotation databases

EnsemblBacteriaiABO68257; ABO68257; GTNG_2912.
GeneIDi4967838.
KEGGigtn:GTNG_2912.
PATRICi21982447. VBIGeoThe136879_3067.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000557 Genomic DNA. Translation: ABO68257.1 .
RefSeqi WP_011888121.1. NC_009328.1.
YP_001127002.1. NC_009328.1.

3D structure databases

ProteinModelPortali A4ISF3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 420246.GTNG_2912.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABO68257 ; ABO68257 ; GTNG_2912 .
GeneIDi 4967838.
KEGGi gtn:GTNG_2912.
PATRICi 21982447. VBIGeoThe136879_3067.

Phylogenomic databases

eggNOGi COG0083.
HOGENOMi HOG000247200.
KOi K00872.
OMAi MQDRLHQ.
OrthoDBi EOG6DG2WK.

Enzyme and pathway databases

UniPathwayi UPA00050 ; UER00064 .
BioCyci GTHE420246:GIXT-3007-MONOMER.

Family and domain databases

Gene3Di 3.30.230.10. 1 hit.
3.30.70.890. 1 hit.
HAMAPi MF_00384. Homoser_kinase.
InterProi IPR013750. GHMP_kinase_C_dom.
IPR006204. GHMP_kinase_N_dom.
IPR006203. GHMP_knse_ATP-bd_CS.
IPR000870. Homoserine_kinase.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view ]
Pfami PF08544. GHMP_kinases_C. 1 hit.
PF00288. GHMP_kinases_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000676. Homoser_kin. 1 hit.
SUPFAMi SSF54211. SSF54211. 1 hit.
SSF55060. SSF55060. 1 hit.
TIGRFAMsi TIGR00191. thrB. 1 hit.
PROSITEi PS00627. GHMP_KINASES_ATP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome and proteome of long-chain alkane degrading Geobacillus thermodenitrificans NG80-2 isolated from a deep-subsurface oil reservoir."
    Feng L., Wang W., Cheng J., Ren Y., Zhao G., Gao C., Tang Y., Liu X., Han W., Peng X., Liu R., Wang L.
    Proc. Natl. Acad. Sci. U.S.A. 104:5602-5607(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NG80-2Imported.

Entry informationi

Entry nameiA4ISF3_GEOTN
AccessioniPrimary (citable) accession number: A4ISF3
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2007
Last sequence update: May 1, 2007
Last modified: October 29, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3