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A4ISF3 (A4ISF3_GEOTN) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Homoserine kinase HAMAP-Rule MF_00384
Short name=HK HAMAP-Rule MF_00384
Short name=HSK HAMAP-Rule MF_00384
EC=2.7.1.39 HAMAP-Rule MF_00384
Gene names
Name:thrB HAMAP-Rule MF_00384
Ordered Locus Names:GTNG_2912 EMBL ABO68257.1
OrganismGeobacillus thermodenitrificans (strain NG80-2) [Complete proteome] [HAMAP] EMBL ABO68257.1
Taxonomic identifier420246 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Geobacillus ›

Protein attributes

Sequence length304 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate By similarity. HAMAP-Rule MF_00384 SAAS SAAS000870

Catalytic activity

ATP + L-homoserine = ADP + O-phospho-L-homoserine. HAMAP-Rule MF_00384 SAAS SAAS000870

Pathway

Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5. HAMAP-Rule MF_00384 SAAS SAAS000870

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00384 SAAS SAAS000870.

Sequence similarities

Belongs to the GHMP kinase family. Homoserine kinase subfamily. HAMAP-Rule MF_00384

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding90 – 10011ATP By similarity HAMAP-Rule MF_00384

Sequences

Sequence LengthMass (Da)Tools
A4ISF3 [UniParc].

Last modified May 1, 2007. Version 1.
Checksum: 4E8079118E217B6D

FASTA30432,946
        10         20         30         40         50         60 
MKEDEMLKIV VPGSTANLGP GFDSVGLAVS RYLTLDVRLA RTWSFTPKTA EVSDIPRGTD 

        70         80         90        100        110        120 
NLVYKVANET AKAHGRQLPS CEVDVYSDIP FTRGLGSSAA AVVAGIELAD ALLELGLTRE 

       130        140        150        160        170        180 
QKMELATRYE GHPDNVGASL YGGLVIGCYR EAGVDVVHVP ELAIELVAII PAYELETKKA 

       190        200        210        220        230        240 
RGQLPEQWMR QQAVEASAIS NVLVAALLTK NWKLAGRMMA ADLFHQPYRK SLVPELERAQ 

       250        260        270        280        290        300 
ALAEEYEAIG AALSGAGPTV LVFAEPGKGE QLERQLRPHF PACEVTWLAI EPHGSRVYKL 


ALEA

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References

[1]"Genome and proteome of long-chain alkane degrading Geobacillus thermodenitrificans NG80-2 isolated from a deep-subsurface oil reservoir."
Feng L., Wang W., Cheng J., Ren Y., Zhao G., Gao C., Tang Y., Liu X., Han W., Peng X., Liu R., Wang L.
Proc. Natl. Acad. Sci. U.S.A. 104:5602-5607(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NG80-2 EMBL ABO68257.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000557 Genomic DNA. Translation: ABO68257.1.
RefSeqYP_001127002.1. NC_009328.1.

3D structure databases

ProteinModelPortalA4ISF3.
ModBaseSearch...

Protein-protein interaction databases

STRING420246.GTNG_2912.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABO68257; ABO68257; GTNG_2912.
GeneID4967838.
KEGGgtn:GTNG_2912.
PATRIC21982447. VBIGeoThe136879_3067.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0083.
HOGENOMHOG000247200.
KOK00872.
OMALHEPYRW.
ProtClustDBPRK01212.

Enzyme and pathway databases

BioCycGTHE420246:GIXT-3007-MONOMER.
UniPathwayUPA00050; UER00064.

Family and domain databases

Gene3D3.30.230.10. 1 hit.
HAMAPMF_00384. Homoser_kinase.
InterProIPR013750. GHMP_kinase_C_dom.
IPR006204. GHMP_kinase_N_dom.
IPR006203. GHMP_knse_ATP-bd_CS.
IPR000870. Homoserine_kinase.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PfamPF08544. GHMP_kinases_C. 1 hit.
PF00288. GHMP_kinases_N. 1 hit.
[Graphical view]
PIRSFPIRSF000676. Homoser_kin. 1 hit.
PRINTSPR00958. HOMSERKINASE.
SUPFAMSSF54211. Ribosomal_S5_D2-typ_fold. 1 hit.
TIGRFAMsTIGR00191. thrB. 1 hit.
PROSITEPS00627. GHMP_KINASES_ATP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA4ISF3_GEOTN
AccessionPrimary (citable) accession number: A4ISF3
Entry history
Integrated into UniProtKB/TrEMBL: May 1, 2007
Last sequence update: May 1, 2007
Last modified: May 1, 2013
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info