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A4IRY3

- SYL_GEOTN

UniProt

A4IRY3 - SYL_GEOTN

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Geobacillus thermodenitrificans (strain NG80-2)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei579 – 5791ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciGTHE420246:GIXT-2819-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:GTNG_2742
OrganismiGeobacillus thermodenitrificans (strain NG80-2)
Taxonomic identifieri420246 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus
ProteomesiUP000001578: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 805805Leucine--tRNA ligasePRO_0000334760Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi420246.GTNG_2742.

Structurei

3D structure databases

ProteinModelPortaliA4IRY3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi40 – 5112"HIGH" regionAdd
BLAST
Motifi576 – 5805"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4IRY3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSFNHREIEK KWQDYWEQHK TFRTPDESDK PKFYVLDMFP YPSGAGLHVG
60 70 80 90 100
HPEGYTATDI LARMKRMQGY NVLHPMGWDA FGLPAEQYAL DTGNDPAEFT
110 120 130 140 150
QKNIDNFRRQ IKSLGFSYDW DREINTTDPN YYKWTQWIFL KLYEKGLAYM
160 170 180 190 200
DEVPVNWCPA LGTVLANEEV INGRSERGGH PVIRKPMRQW MLKITAYADR
210 220 230 240 250
LLEDLEELDW PESIKEMQRN WIGRSEGAEI EFAVDGHDES FTVFTTRPDT
260 270 280 290 300
LFGATYAVLA PEHPLVEKIT TPEQKPAVDA YLKEVQSKSD LERTDLAKEK
310 320 330 340 350
TGVFTGAYAI HPVTGDKLPI WIADYVLMGY GTGAIMAVPA HDERDYEFAK
360 370 380 390 400
TFNLPIKEVV AGGNVENEPY TGDGEHINSE FLNGLNKQEA IEKMIAWLEE
410 420 430 440 450
NGKGQKKVSY RLRDWLFSRQ RYWGEPIPVI HWEDGTMTTV PEEELPLVLP
460 470 480 490 500
KTDEIKPSGT GESPLANIEE WVNVVDPKTG KKGRRETNTM PQWAGSCWYY
510 520 530 540 550
LRYIDPHNDK QLADPEKLKQ WLPVDVYIGG AEHAVLHLLY ARFWHKVLYD
560 570 580 590 600
LGIVPTKEPF QKLFNQGMIL GENNEKMSKS KGNVVNPDDI VESHGADTLR
610 620 630 640 650
LYEMFMGPLE ASIAWSTKGL DGARRFLERV WRLFVTEDGQ LNPNIVDEPA
660 670 680 690 700
NDTLERVYHQ TVKKVTEDYE ALRFNTAISQ LMVFINEAYK AEQMKKEYME
710 720 730 740 750
GFVKLLSPVC PHIGEELWQK LGHTDTIAYE PWPTYDEAKL VEDVVEIVIQ
760 770 780 790 800
INGKVRAKLN VPADLSKEAL EERALADEKI KEQLAGKTVR KVITVPGKLV

NIVAN
Length:805
Mass (Da):92,346
Last modified:May 20, 2008 - v2
Checksum:i4C47AD64DB2BD5D9
GO

Sequence cautioni

The sequence ABO68087.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000557 Genomic DNA. Translation: ABO68087.1. Different initiation.
RefSeqiYP_001126832.1. NC_009328.1.

Genome annotation databases

EnsemblBacteriaiABO68087; ABO68087; GTNG_2742.
GeneIDi4967668.
KEGGigtn:GTNG_2742.
PATRICi21982053. VBIGeoThe136879_2888.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000557 Genomic DNA. Translation: ABO68087.1 . Different initiation.
RefSeqi YP_001126832.1. NC_009328.1.

3D structure databases

ProteinModelPortali A4IRY3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 420246.GTNG_2742.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABO68087 ; ABO68087 ; GTNG_2742 .
GeneIDi 4967668.
KEGGi gtn:GTNG_2742.
PATRICi 21982053. VBIGeoThe136879_2888.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci GTHE420246:GIXT-2819-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome and proteome of long-chain alkane degrading Geobacillus thermodenitrificans NG80-2 isolated from a deep-subsurface oil reservoir."
    Feng L., Wang W., Cheng J., Ren Y., Zhao G., Gao C., Tang Y., Liu X., Han W., Peng X., Liu R., Wang L.
    Proc. Natl. Acad. Sci. U.S.A. 104:5602-5607(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NG80-2.

Entry informationi

Entry nameiSYL_GEOTN
AccessioniPrimary (citable) accession number: A4IRY3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: October 29, 2014
This is version 61 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3