Reviewed, UniProtKB/Swiss-Prot A4IQV4 (GCSPA_GEOTN)

Names and origin

Protein names

Recommended name:
    Probable glycine dehydrogenase [decarboxylating] subunit 1
    EC=1.4.4.2
Alternative name(s):
    Glycine decarboxylase subunit 1
    Glycine cleavage system P-protein subunit 1

Gene names

Name:	gcvPA
Ordered Locus Names:	GTNG_2363

Organism

Geobacillus thermodenitrificans (strain NG80-2) [Complete proteome] [HAMAP]

Taxonomic identifier

420246 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Geobacillus

Protein attributes

Sequence length	448 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.
Catalytic activity	Glycine + H-protein-lipoyllysine = H-protein-S-aminomethyldihydrolipoyllysine + CO2. HAMAP MF_00712
Subunit structure	The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is an heterodimer of two subunits By similarity.
Sequence similarities	Belongs to the gcvP family. N-terminal subunit subfamily.

Ontologies

Keywords
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycine decarboxylation via glycine cleavage system Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	glycine dehydrogenase (decarboxylating) activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 448	448	Probable glycine dehydrogenase [decarboxylating] subunit 1 HAMAP MF_00712		PRO_1000045657

Sequences

	Sequence		Length	Mass (Da)
	A4IQV4-1 [UniParc]. Last modified May 1, 2007. Version 1. Checksum: 918C47A42E927F7F	FASTA	448	49,693
	10 20 30 40 50 60 MLHRYLPMTE EDKQEMLKTI GVASIDELFA DIPEQVRFRG ELNVKRAKSE PELWKELSAL 70 80 90 100 110 120 ADKNANARQY VSFLGAGVYD HYIPAVVDHV LMRSEFYTAY TPYQPEISQG ELQAIFEFQT 130 140 150 160 170 180 MVCELTGMDV ANSSMYDGGT ALAEAVLLSA AHTKRRKVLI SNAVHPQYRE VVRTYANGQR 190 200 210 220 230 240 LEVKEIPYNG GVTDLEVLAA EMGDDVACVV IQYPNFFGQI EPLKAIEPLV HEKKSLFVVA 250 260 270 280 290 300 SNPLALGVLT PPGEFGADIV VGDMQPFGIP MQFGGPHCGY FAVKAPLMRK IPGRLVGQTT 310 320 330 340 350 360 DEEGRRGFVL TLQAREQHIR RDKATSNICS NQALNALAAS VALSALGKRG VKEMATMNMQ 370 380 390 400 410 420 KAHYAKSELQ KRGLLSPFAG PFFNEFVIRL NQPVDDVNAR LRQKGIIGGY NLGFDYPELA 430 440 NHMLVAVTEL RTKEEIDRFV NELGDGHA

References

[1]

"Genome and proteome of long-chain alkane degrading Geobacillus thermodenitrificans NG80-2 isolated from a deep-subsurface oil reservoir." Feng L., Wang W., Cheng J., Ren Y., Zhao G., Gao C., Tang Y., Liu X., Han W., Peng X., Liu R., Wang L. Proc. Natl. Acad. Sci. U.S.A. 104:5602-5607(2007) [PubMed: 17372208] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000557 Genomic DNA. Translation: ABO67708.1.
RefSeq	YP_001126453.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4967289.
GenomeReviews	Gene locus GTNG_2363 in contig CP000557_GR.
KEGG	gtn:GTNG_2363.
NMPDR	fig|420246.5.peg.2269.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	A4IQV4. VANASMY.
Family and domain databases
HAMAP	MF_00712. [Tree]
InterPro	IPR003437. GDC-P. IPR015421. PyrdxlP-dep_Trfase_major_sub1. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
PANTHER	PTHR11773. GDC-P. 1 hit.
Pfam	PF02347. GDC-P. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GCSPA_GEOTN

Accession

Primary (citable) accession number: A4IQV4

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	May 1, 2007
Last modified:	June 16, 2009
This is version 17 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)