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A4IQV4 (GCSPA_GEOTN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein subunit 1
Glycine decarboxylase subunit 1
Glycine dehydrogenase (aminomethyl-transferring) subunit 1
Gene names
Name:gcvPA
Ordered Locus Names:GTNG_2363
OrganismGeobacillus thermodenitrificans (strain NG80-2) [Complete proteome] [HAMAP]
Taxonomic identifier420246 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus

Protein attributes

Sequence length448 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00712

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00712

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Sequence similarities

Belongs to the GcvP family. N-terminal subunit subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 448448Probable glycine dehydrogenase (decarboxylating) subunit 1 HAMAP-Rule MF_00712
PRO_1000045657

Sequences

Sequence LengthMass (Da)Tools
A4IQV4 [UniParc].

Last modified May 1, 2007. Version 1.
Checksum: 918C47A42E927F7F

FASTA44849,693
        10         20         30         40         50         60 
MLHRYLPMTE EDKQEMLKTI GVASIDELFA DIPEQVRFRG ELNVKRAKSE PELWKELSAL 

        70         80         90        100        110        120 
ADKNANARQY VSFLGAGVYD HYIPAVVDHV LMRSEFYTAY TPYQPEISQG ELQAIFEFQT 

       130        140        150        160        170        180 
MVCELTGMDV ANSSMYDGGT ALAEAVLLSA AHTKRRKVLI SNAVHPQYRE VVRTYANGQR 

       190        200        210        220        230        240 
LEVKEIPYNG GVTDLEVLAA EMGDDVACVV IQYPNFFGQI EPLKAIEPLV HEKKSLFVVA 

       250        260        270        280        290        300 
SNPLALGVLT PPGEFGADIV VGDMQPFGIP MQFGGPHCGY FAVKAPLMRK IPGRLVGQTT 

       310        320        330        340        350        360 
DEEGRRGFVL TLQAREQHIR RDKATSNICS NQALNALAAS VALSALGKRG VKEMATMNMQ 

       370        380        390        400        410        420 
KAHYAKSELQ KRGLLSPFAG PFFNEFVIRL NQPVDDVNAR LRQKGIIGGY NLGFDYPELA 

       430        440 
NHMLVAVTEL RTKEEIDRFV NELGDGHA 

« Hide

References

[1]"Genome and proteome of long-chain alkane degrading Geobacillus thermodenitrificans NG80-2 isolated from a deep-subsurface oil reservoir."
Feng L., Wang W., Cheng J., Ren Y., Zhao G., Gao C., Tang Y., Liu X., Han W., Peng X., Liu R., Wang L.
Proc. Natl. Acad. Sci. U.S.A. 104:5602-5607(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NG80-2.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000557 Genomic DNA. Translation: ABO67708.1.
RefSeqYP_001126453.1. NC_009328.1.

3D structure databases

ProteinModelPortalA4IQV4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING420246.GTNG_2363.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABO67708; ABO67708; GTNG_2363.
GeneID4967289.
KEGGgtn:GTNG_2363.
PATRIC21981259. VBIGeoThe136879_2491.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0403.
HOGENOMHOG000132025.
KOK00282.
OMASMYDGST.
OrthoDBEOG6XWV3B.
ProtClustDBPRK00451.

Enzyme and pathway databases

BioCycGTHE420246:GIXT-2440-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
HAMAPMF_00712. GcvPA.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023010. GDC_P_su1.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFPIRSF006815. GcvPA. 1 hit.
SUPFAMSSF53383. SSF53383. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSPA_GEOTN
AccessionPrimary (citable) accession number: A4IQV4
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 1, 2007
Last modified: February 19, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families