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A4IQK7

- NAMA_GEOTN

UniProt

A4IQK7 - NAMA_GEOTN

Protein

NADPH dehydrogenase

Gene

namA

Organism
Geobacillus thermodenitrificans (strain NG80-2)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 48 (01 Oct 2014)
      Sequence version 1 (01 May 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the reduction of the double bond of an array of alpha,beta-unsaturated aldehydes and ketones. It also reduces the nitro group of nitroester and nitroaromatic compounds. It could have a role in detoxification processes.UniRule annotation

    Catalytic activityi

    NADPH + acceptor = NADP+ + reduced acceptor.UniRule annotation

    Cofactori

    FMN.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei28 – 281SubstrateUniRule annotation
    Binding sitei164 – 1641SubstrateUniRule annotation
    Binding sitei167 – 1671SubstrateUniRule annotation
    Binding sitei215 – 2151FMNUniRule annotation
    Binding sitei308 – 3081FMNUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi23 – 275FMNUniRule annotation

    GO - Molecular functioni

    1. FMN binding Source: UniProtKB-HAMAP
    2. NADP binding Source: UniProtKB-HAMAP
    3. NADPH dehydrogenase activity Source: UniProtKB-HAMAP
    4. pentaerythritol trinitrate reductase activity Source: UniProtKB-EC
    5. trichloro-p-hydroquinone reductive dehalogenase activity Source: UniProtKB-EC

    GO - Biological processi

    1. response to toxic substance Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Detoxification

    Keywords - Ligandi

    Flavoprotein, FMN, NADP

    Enzyme and pathway databases

    BioCyciGTHE420246:GIXT-2340-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NADPH dehydrogenaseUniRule annotation (EC:1.6.99.1UniRule annotation)
    Gene namesi
    Name:namAUniRule annotation
    Ordered Locus Names:GTNG_2262
    OrganismiGeobacillus thermodenitrificans (strain NG80-2)
    Taxonomic identifieri420246 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus
    ProteomesiUP000001578: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 340340NADPH dehydrogenasePRO_1000069457Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi420246.GTNG_2262.

    Structurei

    3D structure databases

    ProteinModelPortaliA4IQK7.
    SMRiA4IQK7. Positions 5-338.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NADH:flavin oxidoreductase/NADH oxidase family. NamA subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1902.
    HOGENOMiHOG000116232.
    OMAiPWLGKHG.
    OrthoDBiEOG60PHD0.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_01614. NamA.
    InterProiIPR013785. Aldolase_TIM.
    IPR023663. NADPH_DH.
    IPR001155. OxRdtase_FMN_N.
    [Graphical view]
    PfamiPF00724. Oxidored_FMN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A4IQK7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNTVLFSPYT TRGLTLKNRI VMSPMCMYSC DTKDGTVRTW HKIHYPARAI    50
    GQVGLIIVEA TGVTPQGRIS EHDLGIWDDD HIHGLHELVG LVKEHGAAIG 100
    IQLAHAGRKS EVPGEIIAPS AIPFNESSPT PKEMTKADIE KTVQAFQDGA 150
    RRAKKAGFDV IEIHAAHGYL INEFLSPLSN RRQDEYGGSP ENRYHFLGEV 200
    IDAVREVWDG PLFVRISASD YHPDGLTVKD YVPYVKRMKE QGVDLVDVSS 250
    GAVVPARIDV YPGYQVPFAE FIRREAGIPT GAVGLITSGW QAEEVLHNGR 300
    ADLVFLGREL LRNPYWPYAA AKELGVKIEA PVQYERGWRF 340
    Length:340
    Mass (Da):37,782
    Last modified:May 1, 2007 - v1
    Checksum:i99279A48DB537944
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000557 Genomic DNA. Translation: ABO67611.1.
    RefSeqiWP_011887749.1. NC_009328.1.
    YP_001126356.1. NC_009328.1.

    Genome annotation databases

    EnsemblBacteriaiABO67611; ABO67611; GTNG_2262.
    GeneIDi4967189.
    KEGGigtn:GTNG_2262.
    PATRICi21981049. VBIGeoThe136879_2386.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000557 Genomic DNA. Translation: ABO67611.1 .
    RefSeqi WP_011887749.1. NC_009328.1.
    YP_001126356.1. NC_009328.1.

    3D structure databases

    ProteinModelPortali A4IQK7.
    SMRi A4IQK7. Positions 5-338.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 420246.GTNG_2262.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABO67611 ; ABO67611 ; GTNG_2262 .
    GeneIDi 4967189.
    KEGGi gtn:GTNG_2262.
    PATRICi 21981049. VBIGeoThe136879_2386.

    Phylogenomic databases

    eggNOGi COG1902.
    HOGENOMi HOG000116232.
    OMAi PWLGKHG.
    OrthoDBi EOG60PHD0.

    Enzyme and pathway databases

    BioCyci GTHE420246:GIXT-2340-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_01614. NamA.
    InterProi IPR013785. Aldolase_TIM.
    IPR023663. NADPH_DH.
    IPR001155. OxRdtase_FMN_N.
    [Graphical view ]
    Pfami PF00724. Oxidored_FMN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome and proteome of long-chain alkane degrading Geobacillus thermodenitrificans NG80-2 isolated from a deep-subsurface oil reservoir."
      Feng L., Wang W., Cheng J., Ren Y., Zhao G., Gao C., Tang Y., Liu X., Han W., Peng X., Liu R., Wang L.
      Proc. Natl. Acad. Sci. U.S.A. 104:5602-5607(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NG80-2.

    Entry informationi

    Entry nameiNAMA_GEOTN
    AccessioniPrimary (citable) accession number: A4IQK7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: May 1, 2007
    Last modified: October 1, 2014
    This is version 48 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3