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Reviewed, UniProtKB/Swiss-Prot A4IQK7 (NAMA_GEOTN)

Last modified January 19, 2010. Version 21. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    NADPH dehydrogenase
    EC=1.6.99.1
Alternative name(s):
    Xenobiotic reductase
Gene names
Name: namA
Ordered Locus Names: GTNG_2262
OrganismGeobacillus thermodenitrificans (strain NG80-2) [Complete proteome] [HAMAP]
Taxonomic identifier420246 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Geobacillus

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Protein attributes

Sequence length340 AA.
Sequence statusComplete.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

Catalyzes the reduction of the double bond of an array of alpha, beta-unsaturated aldehydes and ketones. It also reduces the nitro group of nitroester and nitroaromatic compounds. It could have a role in detoxification processes By similarity. HAMAP MF_01614

Catalytic activity

NADPH + acceptor = NADP+ + reduced acceptor. HAMAP MF_01614

Cofactor

FMN By similarity. HAMAP MF_01614

Subunit structure

Homotetramer By similarity. HAMAP MF_01614

Sequence similarities

Belongs to the NADH:flavin oxidoreductase/NADH oxidase family. NamA subfamily.

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Ontologies

Keywords
   LigandFMN
Flavoprotein
NADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processoxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionFMN binding

Inferred from electronic annotation. Source: InterPro

NADPH dehydrogenase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 340340NADPH dehydrogenase HAMAP MF_01614
PRO_1000069457

Regions

Nucleotide binding23 – 275FMN By similarity

Sites

Binding site281Substrate By similarity
Binding site1641Substrate By similarity
Binding site1671Substrate By similarity
Binding site2151FMN By similarity
Binding site3081FMN By similarity

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Sequences

Sequence LengthMass (Da)Tools
A4IQK7-1 [UniParc].

Last modified May 1, 2007. Version 1.
Checksum: 99279A48DB537944

FASTA34037,782
        10         20         30         40         50         60 
MNTVLFSPYT TRGLTLKNRI VMSPMCMYSC DTKDGTVRTW HKIHYPARAI GQVGLIIVEA 

        70         80         90        100        110        120 
TGVTPQGRIS EHDLGIWDDD HIHGLHELVG LVKEHGAAIG IQLAHAGRKS EVPGEIIAPS 

       130        140        150        160        170        180 
AIPFNESSPT PKEMTKADIE KTVQAFQDGA RRAKKAGFDV IEIHAAHGYL INEFLSPLSN 

       190        200        210        220        230        240 
RRQDEYGGSP ENRYHFLGEV IDAVREVWDG PLFVRISASD YHPDGLTVKD YVPYVKRMKE 

       250        260        270        280        290        300 
QGVDLVDVSS GAVVPARIDV YPGYQVPFAE FIRREAGIPT GAVGLITSGW QAEEVLHNGR 

       310        320        330        340 
ADLVFLGREL LRNPYWPYAA AKELGVKIEA PVQYERGWRF

« Hide

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References

[1]"Genome and proteome of long-chain alkane degrading Geobacillus thermodenitrificans NG80-2 isolated from a deep-subsurface oil reservoir."
Feng L., Wang W., Cheng J., Ren Y., Zhao G., Gao C., Tang Y., Liu X., Han W., Peng X., Liu R., Wang L.
Proc. Natl. Acad. Sci. U.S.A. 104:5602-5607(2007) [PubMed: 17372208] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000557 Genomic DNA. Translation: ABO67611.1.
RefSeqYP_001126356.1.

3D structure databases

SMRA4IQK7. Positions 5-338.
ModBaseSearch...

Protein-protein interaction databases

STRINGA4IQK7.

Genome annotation databases

GeneID4967189.
GenomeReviewsGene locus GTNG_2262 in contig CP000557_GR.
KEGGgtn:GTNG_2262.
NMPDRfig|420246.5.peg.2170.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1902.
HOGENOMHBG583461.
OMAPQGRISE.
PhylomeDBA4IQK7.

Family and domain databases

HAMAPMF_01614. NamA.
[Tree]
InterProIPR013785. Aldolase_TIM.
IPR001155. OxRdtase_FMN_N.
[Graphical view]
Gene3DG3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
PfamPF00724. Oxidored_FMN. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameNAMA_GEOTN
AccessionPrimary (citable) accession number: A4IQK7
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: May 1, 2007
Last modified: January 19, 2010
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents