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A4IQK7

- NAMA_GEOTN

UniProt

A4IQK7 - NAMA_GEOTN

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Protein
NADPH dehydrogenase
Gene
namA, GTNG_2262
Organism
Geobacillus thermodenitrificans (strain NG80-2)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the reduction of the double bond of an array of alpha,beta-unsaturated aldehydes and ketones. It also reduces the nitro group of nitroester and nitroaromatic compounds. It could have a role in detoxification processes By similarity.UniRule annotation

Catalytic activityi

NADPH + acceptor = NADP+ + reduced acceptor.UniRule annotation

Cofactori

FMN By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei28 – 281Substrate By similarity
Binding sitei164 – 1641Substrate By similarity
Binding sitei167 – 1671Substrate By similarity
Binding sitei215 – 2151FMN By similarity
Binding sitei308 – 3081FMN By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi23 – 275FMN By similarity

GO - Molecular functioni

  1. FMN binding Source: UniProtKB-HAMAP
  2. NADP binding Source: UniProtKB-HAMAP
  3. NADPH dehydrogenase activity Source: UniProtKB-HAMAP
  4. pentaerythritol trinitrate reductase activity Source: UniProtKB-EC
  5. trichloro-p-hydroquinone reductive dehalogenase activity Source: UniProtKB-EC

GO - Biological processi

  1. response to toxic substance Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Detoxification

Keywords - Ligandi

Flavoprotein, FMN, NADP

Enzyme and pathway databases

BioCyciGTHE420246:GIXT-2340-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NADPH dehydrogenase (EC:1.6.99.1)
Gene namesi
Name:namA
Ordered Locus Names:GTNG_2262
OrganismiGeobacillus thermodenitrificans (strain NG80-2)
Taxonomic identifieri420246 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus
ProteomesiUP000001578: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 340340NADPH dehydrogenaseUniRule annotation
PRO_1000069457Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi420246.GTNG_2262.

Structurei

3D structure databases

ProteinModelPortaliA4IQK7.
SMRiA4IQK7. Positions 5-338.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1902.
HOGENOMiHOG000116232.
OMAiPWLGKHG.
OrthoDBiEOG60PHD0.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01614. NamA.
InterProiIPR013785. Aldolase_TIM.
IPR023663. NADPH_DH.
IPR001155. OxRdtase_FMN_N.
[Graphical view]
PfamiPF00724. Oxidored_FMN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4IQK7-1 [UniParc]FASTAAdd to Basket

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MNTVLFSPYT TRGLTLKNRI VMSPMCMYSC DTKDGTVRTW HKIHYPARAI    50
GQVGLIIVEA TGVTPQGRIS EHDLGIWDDD HIHGLHELVG LVKEHGAAIG 100
IQLAHAGRKS EVPGEIIAPS AIPFNESSPT PKEMTKADIE KTVQAFQDGA 150
RRAKKAGFDV IEIHAAHGYL INEFLSPLSN RRQDEYGGSP ENRYHFLGEV 200
IDAVREVWDG PLFVRISASD YHPDGLTVKD YVPYVKRMKE QGVDLVDVSS 250
GAVVPARIDV YPGYQVPFAE FIRREAGIPT GAVGLITSGW QAEEVLHNGR 300
ADLVFLGREL LRNPYWPYAA AKELGVKIEA PVQYERGWRF 340
Length:340
Mass (Da):37,782
Last modified:May 1, 2007 - v1
Checksum:i99279A48DB537944
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000557 Genomic DNA. Translation: ABO67611.1.
RefSeqiWP_011887749.1. NC_009328.1.
YP_001126356.1. NC_009328.1.

Genome annotation databases

EnsemblBacteriaiABO67611; ABO67611; GTNG_2262.
GeneIDi4967189.
KEGGigtn:GTNG_2262.
PATRICi21981049. VBIGeoThe136879_2386.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000557 Genomic DNA. Translation: ABO67611.1 .
RefSeqi WP_011887749.1. NC_009328.1.
YP_001126356.1. NC_009328.1.

3D structure databases

ProteinModelPortali A4IQK7.
SMRi A4IQK7. Positions 5-338.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 420246.GTNG_2262.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABO67611 ; ABO67611 ; GTNG_2262 .
GeneIDi 4967189.
KEGGi gtn:GTNG_2262.
PATRICi 21981049. VBIGeoThe136879_2386.

Phylogenomic databases

eggNOGi COG1902.
HOGENOMi HOG000116232.
OMAi PWLGKHG.
OrthoDBi EOG60PHD0.

Enzyme and pathway databases

BioCyci GTHE420246:GIXT-2340-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01614. NamA.
InterProi IPR013785. Aldolase_TIM.
IPR023663. NADPH_DH.
IPR001155. OxRdtase_FMN_N.
[Graphical view ]
Pfami PF00724. Oxidored_FMN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome and proteome of long-chain alkane degrading Geobacillus thermodenitrificans NG80-2 isolated from a deep-subsurface oil reservoir."
    Feng L., Wang W., Cheng J., Ren Y., Zhao G., Gao C., Tang Y., Liu X., Han W., Peng X., Liu R., Wang L.
    Proc. Natl. Acad. Sci. U.S.A. 104:5602-5607(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NG80-2.

Entry informationi

Entry nameiNAMA_GEOTN
AccessioniPrimary (citable) accession number: A4IQK7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: May 1, 2007
Last modified: September 3, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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