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Protein

NADPH dehydrogenase

Gene

namA

Organism
Geobacillus thermodenitrificans (strain NG80-2)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the reduction of the double bond of an array of alpha,beta-unsaturated aldehydes and ketones. It also reduces the nitro group of nitroester and nitroaromatic compounds. It could have a role in detoxification processes.UniRule annotation

Catalytic activityi

NADPH + acceptor = NADP+ + reduced acceptor.UniRule annotation

Cofactori

FMNUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei28SubstrateUniRule annotation1
Binding sitei60FMN; via amide nitrogenUniRule annotation1
Binding sitei102FMNUniRule annotation1
Binding sitei215FMNUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi23 – 26FMNUniRule annotation4
Nucleotide bindingi307 – 308FMNUniRule annotation2

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Detoxification

Keywords - Ligandi

Flavoprotein, FMN, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
NADPH dehydrogenaseUniRule annotation (EC:1.6.99.1UniRule annotation)
Gene namesi
Name:namAUniRule annotation
Ordered Locus Names:GTNG_2262
OrganismiGeobacillus thermodenitrificans (strain NG80-2)
Taxonomic identifieri420246 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus
Proteomesi
  • UP000001578 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000694571 – 340NADPH dehydrogenaseAdd BLAST340

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi420246.GTNG_2262.

Structurei

3D structure databases

ProteinModelPortaliA4IQK7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni164 – 167Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the NADH:flavin oxidoreductase/NADH oxidase family. NamA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CCY. Bacteria.
COG1902. LUCA.
HOGENOMiHOG000116232.
KOiK00354.
OMAiGYQTRFA.
OrthoDBiPOG091H03LJ.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01614. NamA. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR023663. NADPH_DH.
IPR001155. OxRdtase_FMN_N.
[Graphical view]
PfamiPF00724. Oxidored_FMN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4IQK7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTVLFSPYT TRGLTLKNRI VMSPMCMYSC DTKDGTVRTW HKIHYPARAI
60 70 80 90 100
GQVGLIIVEA TGVTPQGRIS EHDLGIWDDD HIHGLHELVG LVKEHGAAIG
110 120 130 140 150
IQLAHAGRKS EVPGEIIAPS AIPFNESSPT PKEMTKADIE KTVQAFQDGA
160 170 180 190 200
RRAKKAGFDV IEIHAAHGYL INEFLSPLSN RRQDEYGGSP ENRYHFLGEV
210 220 230 240 250
IDAVREVWDG PLFVRISASD YHPDGLTVKD YVPYVKRMKE QGVDLVDVSS
260 270 280 290 300
GAVVPARIDV YPGYQVPFAE FIRREAGIPT GAVGLITSGW QAEEVLHNGR
310 320 330 340
ADLVFLGREL LRNPYWPYAA AKELGVKIEA PVQYERGWRF
Length:340
Mass (Da):37,782
Last modified:May 1, 2007 - v1
Checksum:i99279A48DB537944
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000557 Genomic DNA. Translation: ABO67611.1.
RefSeqiWP_011887749.1. NC_009328.1.

Genome annotation databases

EnsemblBacteriaiABO67611; ABO67611; GTNG_2262.
KEGGigtn:GTNG_2262.
PATRICi21981049. VBIGeoThe136879_2386.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000557 Genomic DNA. Translation: ABO67611.1.
RefSeqiWP_011887749.1. NC_009328.1.

3D structure databases

ProteinModelPortaliA4IQK7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi420246.GTNG_2262.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABO67611; ABO67611; GTNG_2262.
KEGGigtn:GTNG_2262.
PATRICi21981049. VBIGeoThe136879_2386.

Phylogenomic databases

eggNOGiENOG4105CCY. Bacteria.
COG1902. LUCA.
HOGENOMiHOG000116232.
KOiK00354.
OMAiGYQTRFA.
OrthoDBiPOG091H03LJ.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01614. NamA. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR023663. NADPH_DH.
IPR001155. OxRdtase_FMN_N.
[Graphical view]
PfamiPF00724. Oxidored_FMN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNAMA_GEOTN
AccessioniPrimary (citable) accession number: A4IQK7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: May 1, 2007
Last modified: November 2, 2016
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.