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A4IPX2

- GLSA_GEOTN

UniProt

A4IPX2 - GLSA_GEOTN

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Protein

Glutaminase

Gene

glsA

Organism
Geobacillus thermodenitrificans (strain NG80-2)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamine + H2O = L-glutamate + NH3.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei65 – 651SubstrateUniRule annotation
Binding sitei117 – 1171SubstrateUniRule annotation
Binding sitei162 – 1621SubstrateUniRule annotation
Binding sitei169 – 1691SubstrateUniRule annotation
Binding sitei193 – 1931SubstrateUniRule annotation
Binding sitei245 – 2451SubstrateUniRule annotation
Binding sitei263 – 2631Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. glutaminase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. glutamine metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciGTHE420246:GIXT-2096-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
GlutaminaseUniRule annotation (EC:3.5.1.2UniRule annotation)
Gene namesi
Name:glsAUniRule annotation
Ordered Locus Names:GTNG_2024
OrganismiGeobacillus thermodenitrificans (strain NG80-2)
Taxonomic identifieri420246 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus
ProteomesiUP000001578: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 309309GlutaminasePRO_1000048337Add
BLAST

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi420246.GTNG_2024.

Structurei

3D structure databases

ProteinModelPortaliA4IPX2.
SMRiA4IPX2. Positions 3-309.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glutaminase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2066.
HOGENOMiHOG000216890.
KOiK01425.
OMAiQRARRIN.
OrthoDBiEOG6N94BK.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
HAMAPiMF_00313. Glutaminase.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view]
PANTHERiPTHR12544. PTHR12544. 1 hit.
PfamiPF04960. Glutaminase. 1 hit.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 1 hit.
TIGRFAMsiTIGR03814. Gln_ase. 1 hit.

Sequencei

Sequence statusi: Complete.

A4IPX2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPVYNKEELV RFVEEAKQYA RYGKVADYIP ALGKANPNEL SIAVYTADGK
60 70 80 90 100
VVDAGDVTVK VTLQSISKIL ALALVLIDRG EDEVFRKVGM EPTGDPFNSI
110 120 130 140 150
AKLEEVQPSK PLNPMINAGA LAVTHMIRGR SVEERLERLL AFIRRLAGNE
160 170 180 190 200
QITYSEEVAQ SEFETAFLNR SLCYFLKQHG IIDEDVEELM DLYTKQCAVE
210 220 230 240 250
MTCIDLARIG LVFALDGRDP HSGELLMPLD VARICKTFMV TCGMYNASGE
260 270 280 290 300
FAIKIGIPAK SGVSGGILAA VPGRCGIGIF GPALDDKGNS LTGVKLLERL

SKTYSLSIF
Length:309
Mass (Da):33,773
Last modified:May 1, 2007 - v1
Checksum:i3FBD20BBCA1996EE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000557 Genomic DNA. Translation: ABO67376.1.
RefSeqiWP_011887640.1. NC_009328.1.
YP_001126121.1. NC_009328.1.

Genome annotation databases

EnsemblBacteriaiABO67376; ABO67376; GTNG_2024.
GeneIDi4966952.
KEGGigtn:GTNG_2024.
PATRICi21980529. VBIGeoThe136879_2133.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000557 Genomic DNA. Translation: ABO67376.1 .
RefSeqi WP_011887640.1. NC_009328.1.
YP_001126121.1. NC_009328.1.

3D structure databases

ProteinModelPortali A4IPX2.
SMRi A4IPX2. Positions 3-309.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 420246.GTNG_2024.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABO67376 ; ABO67376 ; GTNG_2024 .
GeneIDi 4966952.
KEGGi gtn:GTNG_2024.
PATRICi 21980529. VBIGeoThe136879_2133.

Phylogenomic databases

eggNOGi COG2066.
HOGENOMi HOG000216890.
KOi K01425.
OMAi QRARRIN.
OrthoDBi EOG6N94BK.

Enzyme and pathway databases

BioCyci GTHE420246:GIXT-2096-MONOMER.

Family and domain databases

Gene3Di 3.40.710.10. 1 hit.
HAMAPi MF_00313. Glutaminase.
InterProi IPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view ]
PANTHERi PTHR12544. PTHR12544. 1 hit.
Pfami PF04960. Glutaminase. 1 hit.
[Graphical view ]
SUPFAMi SSF56601. SSF56601. 1 hit.
TIGRFAMsi TIGR03814. Gln_ase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome and proteome of long-chain alkane degrading Geobacillus thermodenitrificans NG80-2 isolated from a deep-subsurface oil reservoir."
    Feng L., Wang W., Cheng J., Ren Y., Zhao G., Gao C., Tang Y., Liu X., Han W., Peng X., Liu R., Wang L.
    Proc. Natl. Acad. Sci. U.S.A. 104:5602-5607(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NG80-2.

Entry informationi

Entry nameiGLSA_GEOTN
AccessioniPrimary (citable) accession number: A4IPX2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 1, 2007
Last modified: October 1, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3