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A4IPX2 (GLSA_GEOTN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutaminase

EC=3.5.1.2
Gene names
Name:glsA
Ordered Locus Names:GTNG_2024
OrganismGeobacillus thermodenitrificans (strain NG80-2) [Complete proteome] [HAMAP]
Taxonomic identifier420246 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus

Protein attributes

Sequence length309 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

L-glutamine + H2O = L-glutamate + NH3. HAMAP-Rule MF_00313

Subunit structure

Homotetramer By similarity. HAMAP-Rule MF_00313

Sequence similarities

Belongs to the glutaminase family.

Ontologies

Keywords
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processglutamine metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functionglutaminase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 309309Glutaminase HAMAP-Rule MF_00313
PRO_1000048337

Sites

Binding site651Substrate By similarity
Binding site1171Substrate By similarity
Binding site1621Substrate By similarity
Binding site1691Substrate By similarity
Binding site1931Substrate By similarity
Binding site2451Substrate By similarity
Binding site2631Substrate; via amide nitrogen By similarity

Sequences

Sequence LengthMass (Da)Tools
A4IPX2 [UniParc].

Last modified May 1, 2007. Version 1.
Checksum: 3FBD20BBCA1996EE

FASTA30933,773
        10         20         30         40         50         60 
MPVYNKEELV RFVEEAKQYA RYGKVADYIP ALGKANPNEL SIAVYTADGK VVDAGDVTVK 

        70         80         90        100        110        120 
VTLQSISKIL ALALVLIDRG EDEVFRKVGM EPTGDPFNSI AKLEEVQPSK PLNPMINAGA 

       130        140        150        160        170        180 
LAVTHMIRGR SVEERLERLL AFIRRLAGNE QITYSEEVAQ SEFETAFLNR SLCYFLKQHG 

       190        200        210        220        230        240 
IIDEDVEELM DLYTKQCAVE MTCIDLARIG LVFALDGRDP HSGELLMPLD VARICKTFMV 

       250        260        270        280        290        300 
TCGMYNASGE FAIKIGIPAK SGVSGGILAA VPGRCGIGIF GPALDDKGNS LTGVKLLERL 


SKTYSLSIF 

« Hide

References

[1]"Genome and proteome of long-chain alkane degrading Geobacillus thermodenitrificans NG80-2 isolated from a deep-subsurface oil reservoir."
Feng L., Wang W., Cheng J., Ren Y., Zhao G., Gao C., Tang Y., Liu X., Han W., Peng X., Liu R., Wang L.
Proc. Natl. Acad. Sci. U.S.A. 104:5602-5607(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NG80-2.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000557 Genomic DNA. Translation: ABO67376.1.
RefSeqYP_001126121.1. NC_009328.1.

3D structure databases

ProteinModelPortalA4IPX2.
SMRA4IPX2. Positions 3-309.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING420246.GTNG_2024.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABO67376; ABO67376; GTNG_2024.
GeneID4966952.
KEGGgtn:GTNG_2024.
PATRIC21980529. VBIGeoThe136879_2133.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2066.
HOGENOMHOG000216890.
KOK01425.
OMAQRARRIN.
OrthoDBEOG6N94BK.

Enzyme and pathway databases

BioCycGTHE420246:GIXT-2096-MONOMER.

Family and domain databases

Gene3D3.40.710.10. 1 hit.
HAMAPMF_00313. Glutaminase.
InterProIPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view]
PANTHERPTHR12544. PTHR12544. 1 hit.
PfamPF04960. Glutaminase. 1 hit.
[Graphical view]
SUPFAMSSF56601. SSF56601. 1 hit.
TIGRFAMsTIGR03814. Gln_ase. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGLSA_GEOTN
AccessionPrimary (citable) accession number: A4IPX2
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 1, 2007
Last modified: May 14, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families