Reviewed, UniProtKB/Swiss-Prot A4IPF0 (MTLD_GEOTN)

Names and origin

Protein names

Recommended name:
    Mannitol-1-phosphate 5-dehydrogenase
    EC=1.1.1.17

Gene names

Name:	mtlD
Ordered Locus Names:	GTNG_1844

Organism

Geobacillus thermodenitrificans (strain NG80-2) [Complete proteome] [HAMAP]

Taxonomic identifier

420246 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Geobacillus

Protein attributes

Sequence length	385 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-mannitol 1-phosphate + NAD(+) = D-fructose 6-phosphate + NADH.
Sequence similarities	Belongs to the mannitol dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	coenzyme binding Inferred from electronic annotation. Source: InterPro mannitol-1-phosphate 5-dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 385	385	Mannitol-1-phosphate 5-dehydrogenase		PRO_1000011800
Regions
	Nucleotide binding	3 – 14	12	NAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	A4IPF0-1 [UniParc]. Last modified May 1, 2007. Version 1. Checksum: 7C168104B1AFA86D	FASTA	385	42,313
	10 20 30 40 50 60 MRAVHFGAGN IGRGFIGSLL AASGYDVVFV DVNEQIVRLL KERGEYRVII AGERQEEQWV 70 80 90 100 110 120 RGVSALNSQT ERDDVIEAIA SADLVTTAVG PHILPVIAPV IAAGLERRFT VHQKPLHVIA 130 140 150 160 170 180 CENMIGGTET LKQHVVTHLS EAGRQLVEEC VGFLNCAVDR IVPNQTNDDP LAVTVEPFFE 190 200 210 220 230 240 WAIETKNTIG AVPPIQGAHF VADLGPYIER KLFTVNTGHA LAAYLGYQKQ YRTVQEAMKD 250 260 270 280 290 300 SGIRESVEQA LRESGAVLVK KHGWDEQEHR SYIETTIGRF TNPSLSDDIV RVARSPIRKL 310 320 330 340 350 360 GPNDRLVAPA VQYYTLFERV PSGLVKGIAA LLLFDETGDA EATALQQTIE QSGVEGALVQ 370 380 YAGLDNSHPL VVAVKEEYKK MQKEQ

References

[1]

"Genome and proteome of long-chain alkane degrading Geobacillus thermodenitrificans NG80-2 isolated from a deep-subsurface oil reservoir." Feng L., Wang W., Cheng J., Ren Y., Zhao G., Gao C., Tang Y., Liu X., Han W., Peng X., Liu R., Wang L. Proc. Natl. Acad. Sci. U.S.A. 104:5602-5607(2007) [PubMed: 17372208] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000557 Genomic DNA. Translation: ABO67204.1.
RefSeq	YP_001125949.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4966777.
GenomeReviews	Gene locus GTNG_1844 in contig CP000557_GR.
KEGG	gtn:GTNG_1844.
NMPDR	fig|420246.5.peg.1775.
Organism-specific databases
CMR	Search...
Family and domain databases
HAMAP	MF_00196. [Tree]
InterPro	IPR013328. DHase_multihelical. IPR013118. Mannitol_DHase_C. IPR000669. Mannitol_DHase_core. IPR013131. Mannitol_DHase_N. IPR016040. NAD(P)-bd. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit.
Pfam	PF01232. Mannitol_dh. 1 hit. PF08125. Mannitol_dh_C. 1 hit. [Graphical view]
PRINTS	PR00084. MTLDHDRGNASE.
PROSITE	PS00974. MANNITOL_DHGENASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MTLD_GEOTN

Accession

Primary (citable) accession number: A4IPF0

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	May 1, 2007
Last modified:	November 25, 2008
This is version 17 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)