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Protein

5-deoxy-glucuronate isomerase

Gene

iolB

Organism
Geobacillus thermodenitrificans (strain NG80-2)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Involved in the isomerization of 5-deoxy-glucuronate (5DG) to 5-dehydro-2-deoxy-D-gluconate (DKG or 2-deoxy-5-keto-D-gluconate).UniRule annotation

Catalytic activityi

5-deoxy-D-glucuronate = 5-dehydro-2-deoxy-D-gluconate.UniRule annotation

Pathwayi: myo-inositol degradation into acetyl-CoA

This protein is involved in step 4 of the subpathway that synthesizes acetyl-CoA from myo-inositol.UniRule annotation
Proteins known to be involved in the 7 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Inosose dehydratase (iolE)
  3. 3D-(3,5/4)-trihydroxycyclohexane-1,2-dione hydrolase (iolD)
  4. 5-deoxy-glucuronate isomerase (iolB)
  5. 5-dehydro-2-deoxygluconokinase (iolC)
  6. no protein annotated in this organism
  7. Malonate-semialdehyde dehydrogenase 1 (iolA1), Malonate-semialdehyde dehydrogenase 2 (iolA2)
This subpathway is part of the pathway myo-inositol degradation into acetyl-CoA, which is itself part of Polyol metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetyl-CoA from myo-inositol, the pathway myo-inositol degradation into acetyl-CoA and in Polyol metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase

Enzyme and pathway databases

UniPathwayiUPA00076; UER00920.

Names & Taxonomyi

Protein namesi
Recommended name:
5-deoxy-glucuronate isomeraseUniRule annotation (EC:5.3.1.30UniRule annotation)
Short name:
5DG isomeraseUniRule annotation
Gene namesi
Name:iolBUniRule annotation
Ordered Locus Names:GTNG_1808
OrganismiGeobacillus thermodenitrificans (strain NG80-2)
Taxonomic identifieri420246 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus
Proteomesi
  • UP000001578 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003523881 – 2745-deoxy-glucuronate isomeraseAdd BLAST274

Interactioni

Protein-protein interaction databases

STRINGi420246.GTNG_1808.

Structurei

3D structure databases

ProteinModelPortaliA4IPB4.
SMRiA4IPB4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the isomerase IolB family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DH8. Bacteria.
COG3718. LUCA.
HOGENOMiHOG000239754.
KOiK03337.
OMAiHGYDLYY.
OrthoDBiPOG091H0FEO.

Family and domain databases

Gene3Di2.60.120.10. 2 hits.
HAMAPiMF_01673. IolB. 1 hit.
InterProiView protein in InterPro
IPR024203. Deoxy-glucuronate_isom_IolB.
IPR023770. IolB_Bacilli.
IPR021120. KduI/IolB_isomerase.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin_sf.
PfamiView protein in Pfam
PF04962. KduI. 1 hit.
PIRSFiPIRSF036628. IolB. 1 hit.
SUPFAMiSSF51182. SSF51182. 1 hit.
TIGRFAMsiTIGR04378. myo_inos_iolB. 1 hit.

Sequencei

Sequence statusi: Complete.

A4IPB4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRFIISSHS PNEEGNVVRV TPESAGWEYV GFEVYALTKG QTLRKETIDQ
60 70 80 90 100
EACLVLLKGK ANIHTRHERW ENIGLRMDVF EKIPPYSVYV PSNDVYEVQA
110 120 130 140 150
LTDLELAVCL APGKGTYPAR LIPPSEVGVE MRGAGNIERR IHNILPESKP
160 170 180 190 200
ADSLLVVEVF TPEGNWSSYP PHKHDQHNLP HESYLEETYY HQINPDHGFM
210 220 230 240 250
VQRVYTDDRS IDETMVVKNG DVVLVPKGYH PVSAPPGYEG YYLNVMAGPV
260 270
RTWKFRNDPD HEWVMESKLA AKQK
Length:274
Mass (Da):31,184
Last modified:May 1, 2007 - v1
Checksum:i3B73E28C860BA61E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000557 Genomic DNA. Translation: ABO67168.1.
RefSeqiWP_011887533.1. NC_009328.1.

Genome annotation databases

EnsemblBacteriaiABO67168; ABO67168; GTNG_1808.
GeneIDi31761062.
KEGGigtn:GTNG_1808.

Similar proteinsi

Entry informationi

Entry nameiIOLB_GEOTN
AccessioniPrimary (citable) accession number: A4IPB4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 14, 2008
Last sequence update: May 1, 2007
Last modified: November 22, 2017
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families