A4IPA1 (ARAA_GEOTN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
L-arabinose isomerase
EC=5.3.1.4

Gene names

Name:	araA
Ordered Locus Names:	GTNG_1795

Organism

Geobacillus thermodenitrificans (strain NG80-2) [Complete proteome] [HAMAP]

Taxonomic identifier

420246 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Geobacillus

Protein attributes

Sequence length	496 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the conversion of L-arabinose to L-ribulose By similarity. HAMAP MF_00519
Catalytic activity	L-arabinose = L-ribulose. HAMAP MF_00519
Cofactor	Binds 1 manganese ion per subunit By similarity. HAMAP MF_00519
Pathway	Carbohydrate degradation; L-arabinose degradation via L-ribulose; D-xylulose 5-phosphate from L-arabinose (bacterial route): step 1/3. HAMAP MF_00519
Sequence similarities	Belongs to the arabinose isomerase family.

Ontologies

Keywords
Biological process	Arabinose catabolism Carbohydrate metabolism
Ligand	Manganese Metal-binding
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arabinose catabolic process Inferred from electronic annotation. Source: UniProtKB-KW fucose metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	L-arabinose isomerase activity Inferred from electronic annotation. Source: EC L-fucose isomerase activity Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 496	496	L-arabinose isomerase HAMAP MF_00519		PRO_0000312607
Sites
	Metal binding	306	1	Manganese By similarity
	Metal binding	331	1	Manganese By similarity
	Metal binding	348	1	Manganese By similarity
	Metal binding	447	1	Manganese By similarity

Sequences

	Sequence		Length	Mass (Da)
	A4IPA1 [UniParc]. Last modified May 1, 2007. Version 1. Checksum: 37C3029AC6949ABB	FASTA	496	55,899
	10 20 30 40 50 60 MLSLRPYEFW FVTGSQHLYG EEALKQVEEH SRTIVNELNR DSVFPFPLVF KPIVTTPEEI 70 80 90 100 110 120 RNICLEANAS EQCAGVVTWM HTFSPAKMWI GGLLELRKPL LHLHTQFNRD IPWDSIDMDF 130 140 150 160 170 180 MNLNQSAHGD REYGFIGARM GVARKVVVGH WEDPEVRERL AKWMRTAVAF AESRHLKVAR 190 200 210 220 230 240 FGDNMREVAV TEGDKVGAQI QFGWSINGYG IGDLVQSIRD VSEQSVNELL DEYAELYDIV 250 260 270 280 290 300 PAGRQDGPVR ESIREQARIE LGLKAFLQDG NFTAFTTTFE DLHGMKQLPG LAVQRLMAEG 310 320 330 340 350 360 YGFGGEGDWK TAALVRLMKV MADGKGTSFM EDYTYHFEPG NEMILGAHML EVCPTIAATR 370 380 390 400 410 420 PRIEVHPLSI GGKEDPARLV FDGGEGAAVN ASLIDLGHRF RLIVNEVDAV KPEFDMLKLP 430 440 450 460 470 480 VARILWKPRP SLRDSAEAWI LAGGAHHTCF SFAVTAEQLE DFAEMTGIEC VVINEHTSVS 490 SFKNELRWNE VFWRGR

References

[1]

"Genome and proteome of long-chain alkane degrading Geobacillus thermodenitrificans NG80-2 isolated from a deep-subsurface oil reservoir." Feng L., Wang W., Cheng J., Ren Y., Zhao G., Gao C., Tang Y., Liu X., Han W., Peng X., Liu R., Wang L. Proc. Natl. Acad. Sci. U.S.A. 104:5602-5607(2007) [PubMed: 17372208] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NG80-2.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000557 Genomic DNA. Translation: ABO67155.1.
RefSeq	YP_001125900.1. NC_009328.1.
3D structure databases
ProteinModelPortal	A4IPA1.
SMR	A4IPA1. Positions 7-493.
ModBase	Search...
Protein-protein interaction databases
STRING	A4IPA1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4966728.
GenomeReviews	Gene locus GTNG_1795 in contig CP000557_GR.
KEGG	gtn:GTNG_1795.
NMPDR	fig|420246.5.peg.1727.
PATRIC	21980055. VBIGeoThe136879_1896.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2160.
HOGENOM	HBG297198.
OMA	EVCPTIA.
PhylomeDB	A4IPA1.
ProtClustDB	PRK02929.
Enzyme and pathway databases
BioCyc	GTHE420246:GTNG_1795-MONOMER.
Family and domain databases
HAMAP	MF_00519. Arabinose_Isome. [Tree]
InterPro	IPR024664. Ara_Isoase_C. IPR004216. Fuc/Ara_isomerase_C. IPR009015. Fucose_isomerase_N/cen. IPR003762. Lara_isomerase. [Graphical view]
KO	K01804.
Pfam	PF11762. Arabinose_Iso_C. 1 hit. PF02610. Arabinose_Isome. 1 hit. [Graphical view]
PIRSF	PIRSF001478. L-ara_isomerase. 1 hit.
ProDom	PD018364. Lara_isomerase. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF50443. Fuc_isomerase_C. 1 hit. SSF53743. Fuc_isomerase_N. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ARAA_GEOTN

Accession

Primary (citable) accession number: A4IPA1

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 4, 2007
Last sequence update:	May 1, 2007
Last modified:	December 14, 2011
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program