A4IP74 (UXUA_GEOTN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mannonate dehydratase
EC=4.2.1.8

Alternative name(s):
D-mannonate hydrolase

Gene names

Name:	uxuA
Ordered Locus Names:	GTNG_1764

Organism

Geobacillus thermodenitrificans (strain NG80-2) [Complete proteome] [HAMAP]

Taxonomic identifier

420246 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Geobacillus

Protein attributes

Sequence length	371 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O. HAMAP MF_00106
Pathway	Carbohydrate metabolism; pentose and glucuronate interconversion. HAMAP MF_00106
Sequence similarities	Belongs to the mannonate dehydratase family.

Ontologies

Keywords
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glucuronate catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	mannonate dehydratase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 371	371	Mannonate dehydratase HAMAP MF_00106		PRO_1000034328

Sequences

	Sequence		Length	Mass (Da)
	A4IP74 [UniParc]. Last modified May 1, 2007. Version 1. Checksum: 41B32B56ABAFE31E	FASTA	371	42,695
	10 20 30 40 50 60 MKMTFRWFGK DYDTVSLDHI RQIPGVEGIV GALYHIPVGE VWPLEDILEL KRQVNKNGFH 70 80 90 100 110 120 LEVIESVNVH EDIKLGLPSR ERYIENYKQT IRNLSKAGVK VICYNFMPIF DWTRSDLAKR 130 140 150 160 170 180 RPDGSTVLAY EKQKVEQIDP EEMIRRIENG ANGFLLPGWE PERLKTIKPL FALYKGVTED 190 200 210 220 230 240 DLLDHLRYFL EQIVPVAEEC GIQMAIHPDD PPWSVFGLPR IVTNKENLKK IINMVNSPAN 250 260 270 280 290 300 GLTLCSGSLG ANPDNDIPDI FRYFLRMGRV PFVHVRNIEI HTNGDFEETS HRSCDGSLNI 310 320 330 340 350 360 CEIVKVLHES DFQGYIRPDH GRMIWGEQAR PGYGLYDRAL GIMYLLGIWD SLENEKRKRE 370 GDKTCSQSIQ V

References

[1]

"Genome and proteome of long-chain alkane degrading Geobacillus thermodenitrificans NG80-2 isolated from a deep-subsurface oil reservoir." Feng L., Wang W., Cheng J., Ren Y., Zhao G., Gao C., Tang Y., Liu X., Han W., Peng X., Liu R., Wang L. Proc. Natl. Acad. Sci. U.S.A. 104:5602-5607(2007) [PubMed: 17372208] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NG80-2.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000557 Genomic DNA. Translation: ABO67128.1.
RefSeq	YP_001125873.1. NC_009328.1.
3D structure databases
ProteinModelPortal	A4IP74.
ModBase	Search...
Protein-protein interaction databases
STRING	A4IP74.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4966700.
GenomeReviews	Gene locus GTNG_1764 in contig CP000557_GR.
KEGG	gtn:GTNG_1764.
NMPDR	fig|420246.5.peg.1699.
PATRIC	21979993. VBIGeoThe136879_1865.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1312.
HOGENOM	HBG585927.
OMA	GIVWALH.
PhylomeDB	A4IP74.
ProtClustDB	PRK03906.
Enzyme and pathway databases
BioCyc	GTHE420246:GTNG_1764-MONOMER.
Family and domain databases
HAMAP	MF_00106. UxuA. [Tree]
InterPro	IPR004628. Man_deHydtase. IPR013022. Xyl_isomerase-like_TIM-brl. [Graphical view]
Gene3D	G3DSA:3.20.20.150. Xyl_isomerase-like_TIM-brl. 1 hit.
KO	K01686.
Pfam	PF03786. UxuA. 1 hit. [Graphical view]
PIRSF	PIRSF016049. Man_dehyd. 1 hit.
SUPFAM	SSF51658. Xyl_isomerase-like_TIM-brl. 1 hit.
TIGRFAMs	TIGR00695. UxuA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UXUA_GEOTN

Accession

Primary (citable) accession number: A4IP74

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	May 1, 2007
Last modified:	December 14, 2011
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program