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A4IP67 (XYLA_GEOTN) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Xylose isomerase
EC=5.3.1.5
Gene names
Name:xylA
Ordered Locus Names:GTNG_1757
OrganismGeobacillus thermodenitrificans (strain NG80-2) [Complete proteome] [HAMAP]
Taxonomic identifier420246 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Geobacillus

Protein attributes

Sequence length445 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-xylose = D-xylulose. HAMAP MF_00455

Cofactor

Binds 2 magnesium ions per subunit By similarity. HAMAP MF_00455

Subunit structure

Homotetramer By similarity. HAMAP MF_00455

Subcellular location

Cytoplasm By similarity HAMAP MF_00455.

Sequence similarities

Belongs to the xylose isomerase family.

Ontologies

Keywords
   Biological processCarbohydrate metabolism
Pentose shunt
Xylose metabolism
   Cellular componentCytoplasm
   LigandMagnesium
Metal-binding
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processD-xylose metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

pentose-phosphate shunt

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionmetal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

xylose isomerase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 445445Xylose isomerase HAMAP MF_00455
PRO_1000026441

Sites

Active site991 By similarity
Active site1021 By similarity
Metal binding2301Magnesium 1 By similarity
Metal binding2661Magnesium 1 By similarity
Metal binding2661Magnesium 2 By similarity
Metal binding2691Magnesium 2 By similarity
Metal binding2941Magnesium 1 By similarity
Metal binding3051Magnesium 2 By similarity
Metal binding3071Magnesium 2 By similarity
Metal binding3371Magnesium 1 By similarity

Sequences

Sequence LengthMass (Da)Tools
A4IP67 [UniParc].

Last modified May 1, 2007. Version 1.
Checksum: C60D901983FEEDA0

FASTA44550,650
        10         20         30         40         50         60 
MAYFPNIGKI AYEGPESRNP FAFKFYNPEE KVGGKTMEEH LRFSVAYWHT FTGDGSDPFG 

        70         80         90        100        110        120 
VGNMIRPWDK YSGMDLAKAR VEAAFELFEK LNVPFFCFHD VDIAPEGETL SETYKNLDEI 

       130        140        150        160        170        180 
VDMIEEYMKT SKTKLLWNTA NLFSHPRFVH GAATSCNADV FAYAAAKVKK GLEIAKRLGA 

       190        200        210        220        230        240 
ENYVFWGGRE GYETLLNTDM KLELDNLARF FHMAVDYAKE IGFDGQFLIE PKPKEPTKHQ 

       250        260        270        280        290        300 
YDFDVATALA FLQTYGLKDY FKFNIEANHA TLAGHTFEHE LRVARIHGML GSVDANQGDM 

       310        320        330        340        350        360 
LLGWDTDEFP TDLYATTLAM YEILQNGGLG RGGLNFDAKV RRGSFEPEDL FYAHIAGMDS 

       370        380        390        400        410        420 
FAIGLKVAHR LLEDRVFEQF IEERYKSYTE GIGREIVEGT ADFHKLEQYA LQLGEIRNTS 

       430        440 
GRLERLKTLL NQYLLEVSVP SKARL

« Hide

References

[1]"Genome and proteome of long-chain alkane degrading Geobacillus thermodenitrificans NG80-2 isolated from a deep-subsurface oil reservoir."
Feng L., Wang W., Cheng J., Ren Y., Zhao G., Gao C., Tang Y., Liu X., Han W., Peng X., Liu R., Wang L.
Proc. Natl. Acad. Sci. U.S.A. 104:5602-5607(2007) [PubMed: 17372208] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NG80-2.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000557 Genomic DNA. Translation: ABO67121.1.
RefSeqYP_001125866.1. NC_009328.1.

3D structure databases

ProteinModelPortalA4IP67.
SMRA4IP67. Positions 3-437.
ModBaseSearch...

Protein-protein interaction databases

STRINGA4IP67.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4966693.
GenomeReviewsGene locus GTNG_1757 in contig CP000557_GR.
KEGGgtn:GTNG_1757.
NMPDRfig|420246.5.peg.1692.
PATRIC21979979. VBIGeoThe136879_1858.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2115.
HOGENOMHBG297199.
OMALLGWDTD.
PhylomeDBA4IP67.
ProtClustDBPRK05474.

Enzyme and pathway databases

BioCycGTHE420246:GTNG_1757-MONOMER.

Family and domain databases

HAMAPMF_00455. Xylose_isom_A.
[Tree]
InterProIPR013022. Xyl_isomerase-like_TIM-brl.
IPR012307. Xyl_isomerase_TIM-brl.
IPR013452. Xylose_isom_bac.
IPR001998. Xylose_isomerase.
[Graphical view]
Gene3DG3DSA:3.20.20.150. Xyl_isomerase-like_TIM-brl. 1 hit.
KOK01805.
PfamPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
PRINTSPR00688. XYLOSISMRASE.
SUPFAMSSF51658. Xyl_isomerase-like_TIM-brl. 1 hit.
TIGRFAMsTIGR02630. Xylose_isom_A. 1 hit.
PROSITEPS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameXYLA_GEOTN
AccessionPrimary (citable) accession number: A4IP67
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 1, 2007
Last modified: December 14, 2011
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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