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A4INR2 (ARSC_GEOTN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein ArsC
Alternative name(s):
Arsenate reductase
EC=1.20.4.-
Arsenical pump modifier
Low molecular weight protein-tyrosine-phosphatase
EC=3.1.3.48
Gene names
Name:arsC
Ordered Locus Names:GTNG_1600
OrganismGeobacillus thermodenitrificans (strain NG80-2) [Complete proteome] [HAMAP]
Taxonomic identifier420246 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus

Protein attributes

Sequence length140 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Reduces arsenate [As(V)] to arsenite [As(III)] and dephosphorylates tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. Could switch between different functions in different circumstances By similarity. HAMAP-Rule MF_01624

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate. HAMAP-Rule MF_01624

Arsenate + thioredoxin = arsenite + thioredoxin disulfide + H2O. HAMAP-Rule MF_01624

Subunit structure

Monomer By similarity. HAMAP-Rule MF_01624

Sequence similarities

Belongs to the low molecular weight phosphotyrosine protein phosphatase superfamily. ArsC family.

Ontologies

Keywords
   Biological processArsenical resistance
   DomainRedox-active center
   Molecular functionHydrolase
Oxidoreductase
   PTMDisulfide bond
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processresponse to arsenic-containing substance

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionarsenate reductase (thioredoxin) activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

protein tyrosine phosphatase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 140140Protein ArsC HAMAP-Rule MF_01624
PRO_1000073636

Sites

Active site111Nucleophile; for reductase activity and phosphatase activity By similarity
Active site831Nucleophile; for reductase activity By similarity
Active site901Nucleophile; for reductase activity By similarity

Amino acid modifications

Disulfide bond11 ↔ 83Redox-active; alternate By similarity
Disulfide bond83 ↔ 90Redox-active; alternate By similarity

Sequences

Sequence LengthMass (Da)Tools
A4INR2 [UniParc].

Last modified May 1, 2007. Version 1.
Checksum: 7E48B42880FB66AD

FASTA14015,545
        10         20         30         40         50         60 
MKNKKIIYFL CTGNSCRSQM AEGWAKKYLG DDWEVYSAGI EAHGLNPNAV KVMKEVGIDI 

        70         80         90        100        110        120 
SNQTSDVIDP EILNKADLVV TLCGHAADHC PVTPPNVKRV HWGFDDPAKA EGTEEEKLAV 

       130        140 
FRRVRDEIGA RIKKFAETGE 

« Hide

References

[1]"Genome and proteome of long-chain alkane degrading Geobacillus thermodenitrificans NG80-2 isolated from a deep-subsurface oil reservoir."
Feng L., Wang W., Cheng J., Ren Y., Zhao G., Gao C., Tang Y., Liu X., Han W., Peng X., Liu R., Wang L.
Proc. Natl. Acad. Sci. U.S.A. 104:5602-5607(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NG80-2.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000557 Genomic DNA. Translation: ABO66966.1.
RefSeqYP_001125711.1. NC_009328.1.

3D structure databases

ProteinModelPortalA4INR2.
SMRA4INR2. Positions 1-140.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING420246.GTNG_1600.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABO66966; ABO66966; GTNG_1600.
GeneID4966537.
KEGGgtn:GTNG_1600.
PATRIC21979631. VBIGeoThe136879_1693.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0394.
HOGENOMHOG000273093.
KOK03741.
OMAQTSDMID.
OrthoDBEOG6JDWJC.
ProtClustDBPRK13530.

Enzyme and pathway databases

BioCycGTHE420246:GIXT-1672-MONOMER.

Family and domain databases

HAMAPMF_01624. Arsenate_reduct.
InterProIPR014064. Arsenate_reductase_ArsC.
IPR023485. Ptyr_pPase_SF.
IPR017867. Tyr_phospatase_low_mol_wt.
[Graphical view]
PANTHERPTHR11717. PTHR11717. 1 hit.
PfamPF01451. LMWPc. 1 hit.
[Graphical view]
SMARTSM00226. LMWPc. 1 hit.
[Graphical view]
SUPFAMSSF52788. SSF52788. 1 hit.
TIGRFAMsTIGR02691. arsC_pI258_fam. 1 hit.
ProtoNetSearch...

Entry information

Entry nameARSC_GEOTN
AccessionPrimary (citable) accession number: A4INR2
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: May 1, 2007
Last modified: April 16, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families