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Protein

Arsenate reductase

Gene

arsC

Organism
Geobacillus thermodenitrificans (strain NG80-2)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)].UniRule annotation

Catalytic activityi

Arsenate + thioredoxin = arsenite + thioredoxin disulfide + H2O.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei11NucleophileUniRule annotation1
Active sitei83NucleophileUniRule annotation1
Active sitei90NucleophileUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processArsenical resistance

Names & Taxonomyi

Protein namesi
Recommended name:
Arsenate reductaseUniRule annotation (EC:1.20.4.4UniRule annotation)
Gene namesi
Name:arsCUniRule annotation
Ordered Locus Names:GTNG_1600
OrganismiGeobacillus thermodenitrificans (strain NG80-2)
Taxonomic identifieri420246 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus
Proteomesi
  • UP000001578 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000736361 – 140Arsenate reductaseAdd BLAST140

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi11 ↔ 83Redox-active; alternateUniRule annotation
Disulfide bondi83 ↔ 90Redox-active; alternateUniRule annotation

Keywords - PTMi

Disulfide bond

Interactioni

Protein-protein interaction databases

STRINGi420246.GTNG_1600.

Structurei

3D structure databases

ProteinModelPortaliA4INR2.
SMRiA4INR2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the low molecular weight phosphotyrosine protein phosphatase family. Thioredoxin-coupled ArsC subfamily.UniRule annotation

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiENOG4108UXE. Bacteria.
COG0394. LUCA.
HOGENOMiHOG000273093.
KOiK03741.
OMAiCSHADSV.
OrthoDBiPOG091H07DS.

Family and domain databases

HAMAPiMF_01624. Arsenate_reduct. 1 hit.
InterProiView protein in InterPro
IPR014064. Arsenate_reductase_ArsC.
IPR023485. Ptyr_pPase.
IPR036196. Ptyr_pPase_sf.
PfamiView protein in Pfam
PF01451. LMWPc. 1 hit.
SMARTiView protein in SMART
SM00226. LMWPc. 1 hit.
SUPFAMiSSF52788. SSF52788. 1 hit.
TIGRFAMsiTIGR02691. arsC_pI258_fam. 1 hit.

Sequencei

Sequence statusi: Complete.

A4INR2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNKKIIYFL CTGNSCRSQM AEGWAKKYLG DDWEVYSAGI EAHGLNPNAV
60 70 80 90 100
KVMKEVGIDI SNQTSDVIDP EILNKADLVV TLCGHAADHC PVTPPNVKRV
110 120 130 140
HWGFDDPAKA EGTEEEKLAV FRRVRDEIGA RIKKFAETGE
Length:140
Mass (Da):15,545
Last modified:May 1, 2007 - v1
Checksum:i7E48B42880FB66AD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000557 Genomic DNA. Translation: ABO66966.1.
RefSeqiWP_011887409.1. NC_009328.1.

Genome annotation databases

EnsemblBacteriaiABO66966; ABO66966; GTNG_1600.
GeneIDi31760855.
KEGGigtn:GTNG_1600.

Similar proteinsi

Entry informationi

Entry nameiARSC_GEOTN
AccessioniPrimary (citable) accession number: A4INR2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: May 1, 2007
Last modified: October 25, 2017
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families