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Protein

DNA topoisomerase

Gene

GTNG_1531

Organism
Geobacillus thermodenitrificans (strain NG80-2)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.SAAS annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase, TopoisomeraseSAAS annotation

Keywords - Ligandi

DNA-bindingSAAS annotation

Enzyme and pathway databases

BioCyciGTHE420246:GIXT-1605-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA topoisomeraseSAAS annotation (EC:5.99.1.2SAAS annotation)
Gene namesi
Ordered Locus Names:GTNG_1531Imported
OrganismiGeobacillus thermodenitrificans (strain NG80-2)Imported
Taxonomic identifieri420246 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus
Proteomesi
  • UP000001578 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi420246.GTNG_1531.

Structurei

3D structure databases

ProteinModelPortaliA4INJ7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 135134ToprimInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the type IA topoisomerase family.SAAS annotation
Contains Toprim domain.SAAS annotation

Phylogenomic databases

eggNOGiENOG4108IYH. Bacteria.
COG0550. LUCA.
HOGENOMiHOG000086847.
KOiK03169.
OMAiRKVGYQG.
OrthoDBiEOG60CWM6.

Family and domain databases

Gene3Di1.10.460.10. 2 hits.
2.70.20.10. 2 hits.
3.40.50.140. 1 hit.
InterProiIPR000380. Topo_IA.
IPR003601. Topo_IA_2.
IPR023406. Topo_IA_AS.
IPR013497. Topo_IA_cen.
IPR013824. Topo_IA_cen_sub1.
IPR013825. Topo_IA_cen_sub2.
IPR023405. Topo_IA_core_domain.
IPR003602. Topo_IA_DNA-bd_dom.
IPR013498. Topo_IA_Znf.
IPR005738. TopoIII.
IPR006171. Toprim_domain.
[Graphical view]
PANTHERiPTHR11390. PTHR11390. 1 hit.
PfamiPF01131. Topoisom_bac. 1 hit.
PF01751. Toprim. 1 hit.
PF01396. zf-C4_Topoisom. 2 hits.
[Graphical view]
PRINTSiPR00417. PRTPISMRASEI.
SMARTiSM00437. TOP1Ac. 1 hit.
SM00436. TOP1Bc. 1 hit.
SM00493. TOPRIM. 1 hit.
[Graphical view]
SUPFAMiSSF56712. SSF56712. 1 hit.
TIGRFAMsiTIGR01056. topB. 1 hit.
PROSITEiPS00396. TOPOISOMERASE_I_PROK. 1 hit.
PS50880. TOPRIM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4INJ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSLVLAEKP SVARDIARVL GCKKTHKSYL EGPRYIVTWA LGHLVELKMP
60 70 80 90 100
EDYDRKYETW RLEDLPIIPK KMGLKVIRQT SHQFRAIERL AKRRDVKDCI
110 120 130 140 150
IATDAGREGE LVARWILQKI DWKKPIWRLW ISSQTDQAIR DGFRQLKPGT
160 170 180 190 200
QFDRLYESAI CRAEADWLIG LNVTRALTTK YNDPLSAGRV QTPTLAMIIE
210 220 230 240 250
REREIQSFVP VPYWTIHARI GSVTAVWERH GGKRLFDKDE ANELMTRLKG
260 270 280 290 300
QPARVTSVKR KRKSEPVPLP YDLTELQREA NKRFGFSAKK TLSVLQRLYE
310 320 330 340 350
QHKLVTYPRT DSRYLPSDMK ATMTDRLLAM KPGYEDVISS LLTKKNVKAA
360 370 380 390 400
NRVFQDDKVT DHHAIIPTDE RLDLAKLSVD ERKLYDMIAR RFLALFYPPY
410 420 430 440 450
EYETATVVFE IGDETFVARE TAVVNAGFKA VLGKEETEAK PTLLHLSEGQ
460 470 480 490 500
TLASVQLEME QSFTEPPSRY SEADLLAQME RYGLGTPATR ADIIERLVET
510 520 530 540 550
EVVERKDGRF YPTKKGKQLI ELVNEELKSP ELTARWEREL EAIARGKGNP
560 570 580 590 600
KQFLANIRRQ TEQLVTEIKQ SEQTYKAPNL TNLTCPECGS LLKERKTKDG
610 620 630 640 650
RMLVCSNLEC RYRRRRDPKL SNRRCPQCHR RMEMHEGKAG LYFQCRPCNI
660 670 680 690
VEKAEETKRT SAKGTERALL KKYSPSNESF GTSLGELLKQ ALEKKE
Length:696
Mass (Da):80,353
Last modified:May 1, 2007 - v1
Checksum:i8B31B7B70FE03F85
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000557 Genomic DNA. Translation: ABO66901.1.
RefSeqiWP_008879173.1. NC_009328.1.

Genome annotation databases

EnsemblBacteriaiABO66901; ABO66901; GTNG_1531.
KEGGigtn:GTNG_1531.
PATRICi21979491. VBIGeoThe136879_1623.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000557 Genomic DNA. Translation: ABO66901.1.
RefSeqiWP_008879173.1. NC_009328.1.

3D structure databases

ProteinModelPortaliA4INJ7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi420246.GTNG_1531.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABO66901; ABO66901; GTNG_1531.
KEGGigtn:GTNG_1531.
PATRICi21979491. VBIGeoThe136879_1623.

Phylogenomic databases

eggNOGiENOG4108IYH. Bacteria.
COG0550. LUCA.
HOGENOMiHOG000086847.
KOiK03169.
OMAiRKVGYQG.
OrthoDBiEOG60CWM6.

Enzyme and pathway databases

BioCyciGTHE420246:GIXT-1605-MONOMER.

Family and domain databases

Gene3Di1.10.460.10. 2 hits.
2.70.20.10. 2 hits.
3.40.50.140. 1 hit.
InterProiIPR000380. Topo_IA.
IPR003601. Topo_IA_2.
IPR023406. Topo_IA_AS.
IPR013497. Topo_IA_cen.
IPR013824. Topo_IA_cen_sub1.
IPR013825. Topo_IA_cen_sub2.
IPR023405. Topo_IA_core_domain.
IPR003602. Topo_IA_DNA-bd_dom.
IPR013498. Topo_IA_Znf.
IPR005738. TopoIII.
IPR006171. Toprim_domain.
[Graphical view]
PANTHERiPTHR11390. PTHR11390. 1 hit.
PfamiPF01131. Topoisom_bac. 1 hit.
PF01751. Toprim. 1 hit.
PF01396. zf-C4_Topoisom. 2 hits.
[Graphical view]
PRINTSiPR00417. PRTPISMRASEI.
SMARTiSM00437. TOP1Ac. 1 hit.
SM00436. TOP1Bc. 1 hit.
SM00493. TOPRIM. 1 hit.
[Graphical view]
SUPFAMiSSF56712. SSF56712. 1 hit.
TIGRFAMsiTIGR01056. topB. 1 hit.
PROSITEiPS00396. TOPOISOMERASE_I_PROK. 1 hit.
PS50880. TOPRIM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome and proteome of long-chain alkane degrading Geobacillus thermodenitrificans NG80-2 isolated from a deep-subsurface oil reservoir."
    Feng L., Wang W., Cheng J., Ren Y., Zhao G., Gao C., Tang Y., Liu X., Han W., Peng X., Liu R., Wang L.
    Proc. Natl. Acad. Sci. U.S.A. 104:5602-5607(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NG80-2Imported.

Entry informationi

Entry nameiA4INJ7_GEOTN
AccessioniPrimary (citable) accession number: A4INJ7
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2007
Last sequence update: May 1, 2007
Last modified: May 11, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.