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A4IMR6 (MQO_GEOTN) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Probable malate:quinone oxidoreductase
EC=1.1.5.4
Alternative name(s):
MQO
Malate dehydrogenase [quinone]
Gene names
Name:mqo
Ordered Locus Names:GTNG_1250
OrganismGeobacillus thermodenitrificans (strain NG80-2) [Complete proteome] [HAMAP]
Taxonomic identifier420246 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Geobacillus

Protein attributes

Sequence length501 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

(S)-malate + a quinone = oxaloacetate + reduced quinone. HAMAP MF_00212

Cofactor

FAD By similarity. HAMAP MF_00212

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; oxaloacetate from (S)-malate (quinone route): step 1/1. HAMAP MF_00212

Sequence similarities

Belongs to the MQO family.

Ontologies

Keywords
   Biological processTricarboxylic acid cycle
   LigandFAD
Flavoprotein
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processtricarboxylic acid cycle

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionmalate dehydrogenase (menaquinone) activity

Inferred from electronic annotation. Source: EC

malate dehydrogenase (quinone) activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 501501Probable malate:quinone oxidoreductase HAMAP MF_00212
PRO_1000023802

Sequences

Sequence LengthMass (Da)Tools
A4IMR6 [UniParc].

Last modified May 1, 2007. Version 1.
Checksum: 4618C316745A7349

FASTA50155,566
        10         20         30         40         50         60 
MGNKQTKTDV ILIGAGIMSA TLGTLLKELA PEWDITVFER LEEAGVESSN EWNNAGTGHA 

        70         80         90        100        110        120 
ALCELNYTVE KPDGSIDISK AIKINEQFYV SLQFWAYLVN SGVLRDPKEF IRPLPHMSFV 

       130        140        150        160        170        180 
QGEDNVAFLK KRYETMVNNP LFKGMEFSDD PKKLAEWIPL MMENRVVNEP IAATRIESGT 

       190        200        210        220        230        240 
DVNFGALTRK LFEHLKRKNV EIHYRHHVDD IKRTSDGLWE LKVRDLDSGA VERHVAKFVF 

       250        260        270        280        290        300 
IGAGGGSLHL LQKSGIPEGR GIGGFPVSGL FMVCNNPDVV EQHHAKVYGK AKVGAPPMSV 

       310        320        330        340        350        360 
PHLDTRFINN QKMLLFGPFA GFSPKFLKNG SMLDLFTSVK PHNLLTMLAA GVKNMALTNY 

       370        380        390        400        410        420 
LIQQVMLSKE QRMEELREFV PTAKSEEWDV IVAGQRVQVI KDTEAGGKGT LQFGTEVVHA 

       430        440        450        460        470        480 
ADGSIAALLG ASPGASTAVH VMLEVITKCF PERMKEWEPK VREMIPSYGV SLMKNERLLH 

       490        500 
DVQAATAEML GLREGLALQL V

« Hide

References

[1]"Genome and proteome of long-chain alkane degrading Geobacillus thermodenitrificans NG80-2 isolated from a deep-subsurface oil reservoir."
Feng L., Wang W., Cheng J., Ren Y., Zhao G., Gao C., Tang Y., Liu X., Han W., Peng X., Liu R., Wang L.
Proc. Natl. Acad. Sci. U.S.A. 104:5602-5607(2007) [PubMed: 17372208] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NG80-2.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000557 Genomic DNA. Translation: ABO66620.1.
RefSeqYP_001125365.1. NC_009328.1.

3D structure databases

ProteinModelPortalA4IMR6.
ModBaseSearch...

Protein-protein interaction databases

STRINGA4IMR6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4966189.
GenomeReviewsGene locus GTNG_1250 in contig CP000557_GR.
KEGGgtn:GTNG_1250.
NMPDRfig|420246.5.peg.1212.
PATRIC21978865. VBIGeoThe136879_1312.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0579.
HOGENOMHBG289663.
OMAREMIPSY.
PhylomeDBA4IMR6.
ProtClustDBPRK05257.

Enzyme and pathway databases

BioCycGTHE420246:GTNG_1250-MONOMER.

Family and domain databases

HAMAPMF_00212. MQO.
[Tree]
InterProIPR006231. Malate_quinone_OxRdtase.
[Graphical view]
KOK00116.
PANTHERPTHR13847:SF14. PTHR13847:SF14. 1 hit.
PfamPF06039. Mqo. 1 hit.
[Graphical view]
TIGRFAMsTIGR01320. Mal_quin_oxido. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMQO_GEOTN
AccessionPrimary (citable) accession number: A4IMR6
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 1, 2007
Last modified: December 14, 2011
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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