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Reviewed, UniProtKB/Swiss-Prot A4IMP4 (HUTI_GEOTN)

Last modified November 3, 2009. Version 18. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Imidazolonepropionase
    EC=3.5.2.7
Alternative name(s):
    Imidazolone-5-propionate hydrolase
Gene names
Name: hutI
Ordered Locus Names: GTNG_1226
OrganismGeobacillus thermodenitrificans (strain NG80-2) [Complete proteome] [HAMAP]
Taxonomic identifier420246 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Geobacillus

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Protein attributes

Sequence length424 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Catalytic activity

(S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate + H2O = N-formimidoyl-L-glutamate + H+. HAMAP MF_00372

Cofactor

Binds 1 zinc or iron ion per subunit By similarity.

Pathway

Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 3/3. HAMAP MF_00372

Subcellular location

Cytoplasm Potential.

Sequence similarities

Belongs to the hutI family.

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Ontologies

Keywords
   Biological processHistidine metabolism
   Cellular componentCytoplasm
   LigandIron
Metal-binding
Zinc
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processhistidine catabolic process to glutamate and formamide

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionimidazolonepropionase activity

Inferred from electronic annotation. Source: HAMAP

iron ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

zinc ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 424424Imidazolonepropionase HAMAP MF_00372
PRO_0000306462

Sites

Metal binding841Zinc or iron By similarity
Metal binding861Zinc or iron By similarity
Metal binding2541Zinc or iron By similarity
Metal binding3281Zinc or iron By similarity
Binding site931Substrate By similarity
Binding site1061Substrate By similarity
Binding site1561Substrate By similarity
Binding site1891Substrate By similarity
Binding site2571Substrate By similarity

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Sequences

Sequence LengthMass (Da)Tools
A4IMP4-1 [UniParc].

Last modified May 1, 2007. Version 1.
Checksum: 726B0ACC689D039B

FASTA42446,228
        10         20         30         40         50         60 
MRPLFIRRAR QLVTLAGSSA APLVREKMND LQIIENGSVW IERGVIIAVG PDDELAHRFA 

        70         80         90        100        110        120 
DRIGEADVID ARGKTVTPGL IDPHTHLVYA GSREHEWTMR LRGATYMEIM NAGGGIHATT 

       130        140        150        160        170        180 
KATREASEEM LYEESKRRLD LFLLHGVTTV EAKSGYGLSF EGEIKQLEVA KRLHDTHPVD 

       190        200        210        220        230        240 
VVSTFLGAHA VPPEWKDDRD GYIRLIMEVM IPEVSRRGLA EFNDVFCERG VFTPDEARRI 

       250        260        270        280        290        300 
LEAGKAHGLT PKIHADEIEP YGGAELAAEV GAISADHLLR ASDEGLRRMA ERGVIGVLLP 

       310        320        330        340        350        360 
GTAFFLMTQA ADARRLIDNG VPVALATDCN PGSSPTVSLP LVMSLACLHM RMTPAEALAA 

       370        380        390        400        410        420 
ATINAAHAIG RSHVIGSLEP GKKADLAIFN AANYMQIMYY YGVNHTEMVI KGGKIVVNEG 


KVCI

« Hide

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References

[1]"Genome and proteome of long-chain alkane degrading Geobacillus thermodenitrificans NG80-2 isolated from a deep-subsurface oil reservoir."
Feng L., Wang W., Cheng J., Ren Y., Zhao G., Gao C., Tang Y., Liu X., Han W., Peng X., Liu R., Wang L.
Proc. Natl. Acad. Sci. U.S.A. 104:5602-5607(2007) [PubMed: 17372208] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

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Cross-references

Sequence databases

CP000557 Genomic DNA. Translation: ABO66598.1.
RefSeqYP_001125343.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGA4IMP4.

Genome annotation databases

GeneID4966166.
GenomeReviewsGene locus GTNG_1226 in contig CP000557_GR.
KEGGgtn:GTNG_1226.
NMPDRfig|420246.5.peg.1194.

Organism-specific databases

CMRSearch...

Phylogenomic databases

OMAMNMACTL.

Family and domain databases

HAMAPMF_00372.
[Tree]
InterProIPR006680. Amidohydro_1.
IPR005920. HutI.
[Graphical view]
PfamPF01979. Amidohydro_1. 2 hits.
[Graphical view]
TIGRFAMsTIGR01224. hutI. 1 hit.
ProtoNetSearch...

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Entry information

Entry nameHUTI_GEOTN
AccessionPrimary (citable) accession number: A4IMP4
Entry history
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: May 1, 2007
Last modified: November 3, 2009
This is version 18 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents