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A4IL60 (A4IL60_GEOTN) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-oxoacyl-[acyl-carrier-protein] synthase 3 HAMAP MF_01815
EC=2.3.1.180 HAMAP MF_01815
Alternative name(s):
3-oxoacyl-[acyl-carrier-protein] synthase III HAMAP MF_01815
Beta-ketoacyl-ACP synthase III HAMAP MF_01815
Gene names
Name:fabH HAMAP MF_01815 EMBL ABO66064.1
Ordered Locus Names:GTNG_0684
OrganismGeobacillus thermodenitrificans (strain NG80-2) [Complete proteome] [HAMAP]
Taxonomic identifier420246 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Geobacillus

Protein attributes

Sequence length313 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids By similarity. HAMAP MF_01815

Catalytic activity

Acetyl-CoA + malonyl-[acyl-carrier-protein] = acetoacetyl-[acyl-carrier-protein] + CoA + CO2. HAMAP MF_01815

Pathway

Lipid metabolism; fatty acid biosynthesis. HAMAP MF_01815 SAAS SAAS013747

Subunit structure

Homodimer By similarity. HAMAP MF_01815 SAAS SAAS013747

Subcellular location

Cytoplasm By similarity HAMAP MF_01815 SAAS SAAS013747.

Domain

The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH By similarity. HAMAP MF_01815

Sequence similarities

Belongs to the FabH family. HAMAP MF_01815

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region239 – 2435ACP-binding By similarity HAMAP MF_01815

Sites

Active site1151 By similarity HAMAP MF_01815
Active site2381 By similarity HAMAP MF_01815
Active site2681 By similarity HAMAP MF_01815

Sequences

Sequence LengthMass (Da)Tools
A4IL60 [UniParc].

Last modified May 1, 2007. Version 1.
Checksum: 67042F481F94E7BE

FASTA31333,774
        10         20         30         40         50         60 
MSSMGAGIIG VGYYAPEKVL TNADLEKMMD TSDEWIRTRT GIEERRIAPD EMDTSDMAYF 

        70         80         90        100        110        120 
AAEKALAHAG ISAKDIDLIL VATVTPDRPF PSVACMLQER LGAVNAAALD ISAACAGFMY 

       130        140        150        160        170        180 
GVVTASQFID NGAYKYILVV GAEKLSKIID WTDRNTAVLF GDGAGAVVMG PVSPGRGILS 

       190        200        210        220        230        240 
FELGADGTGG KHLYQDEYII MNGREVFKFA VRQMGESSLN VLEKAGLSKN DVDFLIPHQA 

       250        260        270        280        290        300 
NIRIMEAARQ RLELPEEKMS TTIRRYGNTS AASIPISLAE EFEAGKIKDD DVIVMVGFGG 

       310 
GLTWGAIALR WGR

« Hide

References

[1]"Genome and proteome of long-chain alkane degrading Geobacillus thermodenitrificans NG80-2 isolated from a deep-subsurface oil reservoir."
Feng L., Wang W., Cheng J., Ren Y., Zhao G., Gao C., Tang Y., Liu X., Han W., Peng X., Liu R., Wang L.
Proc. Natl. Acad. Sci. U.S.A. 104:5602-5607(2007) [PubMed: 17372208] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000557 Genomic DNA. Translation: ABO66064.1.
RefSeqYP_001124809.1. NC_009328.1.

3D structure databases

ProteinModelPortalA4IL60.
SMRA4IL60. Positions 4-312.
ModBaseSearch...

Protein-protein interaction databases

STRINGA4IL60.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4965627.
GenomeReviewsGene locus GTNG_0684 in contig CP000557_GR.
KEGGgtn:GTNG_0684.
NMPDRfig|420246.5.peg.664.
PATRIC21977675. VBIGeoThe136879_0722.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0332.
HOGENOMHBG649927.
OMAKEIGAIN.
PhylomeDBA4IL60.
ProtClustDBPRK09352.

Family and domain databases

HAMAPMF_01815. FabH.
[Tree]
InterProIPR013751. ACP_syn_III.
IPR013747. ACP_syn_III_C.
IPR004655. FabH_synth.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
Gene3DG3DSA:3.40.47.10. Thiolase-like_subgr. 2 hits.
KOK00648.
PfamPF08545. ACP_syn_III. 1 hit.
PF08541. ACP_syn_III_C. 1 hit.
[Graphical view]
SUPFAMSSF53901. Thiolase-like. 1 hit.
TIGRFAMsTIGR00747. FabH. 1 hit.
ProtoNetSearch...

Entry information

Entry nameA4IL60_GEOTN
AccessionPrimary (citable) accession number: A4IL60
Entry history
Integrated into UniProtKB/TrEMBL: May 1, 2007
Last sequence update: May 1, 2007
Last modified: December 14, 2011
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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