A4IL46 (ARGC_GEOTN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
N-acetyl-gamma-glutamyl-phosphate reductase
Short name=AGPR
EC=1.2.1.38

Alternative name(s):
N-acetyl-glutamate semialdehyde dehydrogenase
Short name=NAGSA dehydrogenase

Gene names

Name:	argC
Ordered Locus Names:	GTNG_0670

Organism

Geobacillus thermodenitrificans (strain NG80-2) [Complete proteome] [HAMAP]

Taxonomic identifier

420246 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Geobacillus

Protein attributes

Sequence length	344 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH. HAMAP MF_00150
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4. HAMAP MF_00150
Subcellular location	Cytoplasm Probable HAMAP MF_00150.
Sequence similarities	Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	N-acetyl-gamma-glutamyl-phosphate reductase activity Inferred from electronic annotation. Source: EC NAD binding Inferred from electronic annotation. Source: InterPro protein dimerization activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 344	344	N-acetyl-gamma-glutamyl-phosphate reductase HAMAP MF_00150		PRO_1000010997
Sites
	Active site	148	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	A4IL46 [UniParc]. Last modified May 1, 2007. Version 1. Checksum: D52DA163FD87BAD9	FASTA	344	37,749
	10 20 30 40 50 60 MKVAIIGATG YSGAELFRLL QAHPHVDRCD VYLSSQDGVH LSESFPHVGA VDGAVLHKLD 70 80 90 100 110 120 IEALAKYDAV FFATPPGVSG EWAPALVDRG VKVIDLSGDF RLKDGAVYER WYGREAAPAA 130 140 150 160 170 180 YLKRAVYGLT EWNRDAVREA ELLSNPGCYP TATLLGLAPL VKERLIEEDS IIVDAKSGVS 190 200 210 220 230 240 GAGRKAGLGT HFSEVNENVK IYKVNAHQHI PEIEQMLGTW NGAMKPITFS THLIPMTRGI 250 260 270 280 290 300 MSTIYAKVKQ PFSLNDLIDL YKTSYEDASF VRIRQPGQFP ATKEVYGSNY CDIGLAYDER 310 320 330 340 TGRVTVVSVI DNLMKGAAGQ AVQNFNLMMG WDEVEGLCFL PTYP

References

[1]

"Genome and proteome of long-chain alkane degrading Geobacillus thermodenitrificans NG80-2 isolated from a deep-subsurface oil reservoir." Feng L., Wang W., Cheng J., Ren Y., Zhao G., Gao C., Tang Y., Liu X., Han W., Peng X., Liu R., Wang L. Proc. Natl. Acad. Sci. U.S.A. 104:5602-5607(2007) [PubMed: 17372208] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NG80-2.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000557 Genomic DNA. Translation: ABO66050.1.
RefSeq	YP_001124795.1. NC_009328.1.
3D structure databases
ProteinModelPortal	A4IL46.
ModBase	Search...
Protein-protein interaction databases
STRING	A4IL46.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4965613.
GenomeReviews	Gene locus GTNG_0670 in contig CP000557_GR.
KEGG	gtn:GTNG_0670.
NMPDR	fig|420246.5.peg.650.
PATRIC	21977647. VBIGeoThe136879_0708.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0002.
HOGENOM	HBG294213.
OMA	TAEDCTT.
PhylomeDB	A4IL46.
ProtClustDB	PRK00436.
Enzyme and pathway databases
BioCyc	GTHE420246:GTNG_0670-MONOMER.
Family and domain databases
HAMAP	MF_00150. ArgC_type1. [Tree]
InterPro	IPR023013. AGPR_AS. IPR000706. AGPR_type-1. IPR016040. NAD(P)-bd_dom. IPR000534. Semialdehyde_DH_NAD-bd. IPR012280. Semialdhyde_DH_dimer_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00145.
Pfam	PF01118. Semialdhyde_dh. 1 hit. PF02774. Semialdhyde_dhC. 1 hit. [Graphical view]
SMART	SM00859. Semialdhyde_dh. 1 hit. [Graphical view]
TIGRFAMs	TIGR01850. ArgC. 1 hit.
PROSITE	PS01224. ARGC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARGC_GEOTN

Accession

Primary (citable) accession number: A4IL46

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	May 1, 2007
Last modified:	December 14, 2011
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program