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A4IJS3

- UPPP_GEOTN

UniProt

A4IJS3 - UPPP_GEOTN

Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Geobacillus thermodenitrificans (strain NG80-2)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (01 May 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

    Catalytic activityi

    Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

    GO - Molecular functioni

    1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dephosphorylation Source: InterPro
    2. peptidoglycan biosynthetic process Source: UniProtKB-KW
    3. regulation of cell shape Source: UniProtKB-KW
    4. response to antibiotic Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Enzyme and pathway databases

    BioCyciGTHE420246:GIXT-225-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
    Alternative name(s):
    Bacitracin resistance proteinUniRule annotation
    Undecaprenyl pyrophosphate phosphataseUniRule annotation
    Gene namesi
    Name:uppPUniRule annotation
    Ordered Locus Names:GTNG_0193
    OrganismiGeobacillus thermodenitrificans (strain NG80-2)
    Taxonomic identifieri420246 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus
    ProteomesiUP000001578: Chromosome

    Subcellular locationi

    Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 273273Undecaprenyl-diphosphatasePRO_0000303028Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi420246.GTNG_0193.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei48 – 6821HelicalUniRule annotationAdd
    BLAST
    Transmembranei89 – 10921HelicalUniRule annotationAdd
    BLAST
    Transmembranei116 – 13621HelicalUniRule annotationAdd
    BLAST
    Transmembranei152 – 17221HelicalUniRule annotationAdd
    BLAST
    Transmembranei193 – 21321HelicalUniRule annotationAdd
    BLAST
    Transmembranei222 – 24221HelicalUniRule annotationAdd
    BLAST
    Transmembranei252 – 27221HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UppP family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1968.
    HOGENOMiHOG000218356.
    KOiK06153.
    OMAiMILVEEF.
    OrthoDBiEOG6QP13M.

    Family and domain databases

    HAMAPiMF_01006. Undec_diphosphatase.
    InterProiIPR003824. UppP.
    [Graphical view]
    PfamiPF02673. BacA. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A4IJS3-1 [UniParc]FASTAAdd to Basket

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    MDWMELLKAV ILGMVEGLTE FAPVSSTGHM IIVDDLWLKS TEFLGKYAAN    50
    TFKVVIQLGS ILAAVVVFKD RFLELLGIRG RHPGGKPRLT LLHVIIGLLP 100
    AGVLGVLFED YIDEHLFSTK TVLIGLVLGA LLMIVADRFA KKAARAQTVD 150
    QITYKQAFLV GLVQCLSLWP GFSRSGSTIA GGVLVGMSHR AAADFTFIMA 200
    VPIMAGASGL SLLKNWQYVT VADIPFFIAG FLSAFVFALL AIRFFLHLIN 250
    RIRLVPFAVY RIALAFIIYF LYF 273
    Length:273
    Mass (Da):30,031
    Last modified:May 1, 2007 - v1
    Checksum:iFD4C8385725D5292
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000557 Genomic DNA. Translation: ABO65577.1.
    RefSeqiWP_011886664.1. NC_009328.1.
    YP_001124322.1. NC_009328.1.

    Genome annotation databases

    EnsemblBacteriaiABO65577; ABO65577; GTNG_0193.
    GeneIDi4965046.
    KEGGigtn:GTNG_0193.
    PATRICi21976561. VBIGeoThe136879_0206.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000557 Genomic DNA. Translation: ABO65577.1 .
    RefSeqi WP_011886664.1. NC_009328.1.
    YP_001124322.1. NC_009328.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 420246.GTNG_0193.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABO65577 ; ABO65577 ; GTNG_0193 .
    GeneIDi 4965046.
    KEGGi gtn:GTNG_0193.
    PATRICi 21976561. VBIGeoThe136879_0206.

    Phylogenomic databases

    eggNOGi COG1968.
    HOGENOMi HOG000218356.
    KOi K06153.
    OMAi MILVEEF.
    OrthoDBi EOG6QP13M.

    Enzyme and pathway databases

    BioCyci GTHE420246:GIXT-225-MONOMER.

    Family and domain databases

    HAMAPi MF_01006. Undec_diphosphatase.
    InterProi IPR003824. UppP.
    [Graphical view ]
    Pfami PF02673. BacA. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00753. undec_PP_bacA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome and proteome of long-chain alkane degrading Geobacillus thermodenitrificans NG80-2 isolated from a deep-subsurface oil reservoir."
      Feng L., Wang W., Cheng J., Ren Y., Zhao G., Gao C., Tang Y., Liu X., Han W., Peng X., Liu R., Wang L.
      Proc. Natl. Acad. Sci. U.S.A. 104:5602-5607(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NG80-2.

    Entry informationi

    Entry nameiUPPP_GEOTN
    AccessioniPrimary (citable) accession number: A4IJS3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: May 1, 2007
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3