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A4IJS3 (UPPP_GEOTN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Ordered Locus Names:GTNG_0193
OrganismGeobacillus thermodenitrificans (strain NG80-2) [Complete proteome] [HAMAP]
Taxonomic identifier420246 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus

Protein attributes

Sequence length273 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 273273Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_0000303028

Regions

Transmembrane48 – 6821Helical; Potential
Transmembrane89 – 10921Helical; Potential
Transmembrane116 – 13621Helical; Potential
Transmembrane152 – 17221Helical; Potential
Transmembrane193 – 21321Helical; Potential
Transmembrane222 – 24221Helical; Potential
Transmembrane252 – 27221Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
A4IJS3 [UniParc].

Last modified May 1, 2007. Version 1.
Checksum: FD4C8385725D5292

FASTA27330,031
        10         20         30         40         50         60 
MDWMELLKAV ILGMVEGLTE FAPVSSTGHM IIVDDLWLKS TEFLGKYAAN TFKVVIQLGS 

        70         80         90        100        110        120 
ILAAVVVFKD RFLELLGIRG RHPGGKPRLT LLHVIIGLLP AGVLGVLFED YIDEHLFSTK 

       130        140        150        160        170        180 
TVLIGLVLGA LLMIVADRFA KKAARAQTVD QITYKQAFLV GLVQCLSLWP GFSRSGSTIA 

       190        200        210        220        230        240 
GGVLVGMSHR AAADFTFIMA VPIMAGASGL SLLKNWQYVT VADIPFFIAG FLSAFVFALL 

       250        260        270 
AIRFFLHLIN RIRLVPFAVY RIALAFIIYF LYF 

« Hide

References

[1]"Genome and proteome of long-chain alkane degrading Geobacillus thermodenitrificans NG80-2 isolated from a deep-subsurface oil reservoir."
Feng L., Wang W., Cheng J., Ren Y., Zhao G., Gao C., Tang Y., Liu X., Han W., Peng X., Liu R., Wang L.
Proc. Natl. Acad. Sci. U.S.A. 104:5602-5607(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NG80-2.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000557 Genomic DNA. Translation: ABO65577.1.
RefSeqYP_001124322.1. NC_009328.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING420246.GTNG_0193.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABO65577; ABO65577; GTNG_0193.
GeneID4965046.
KEGGgtn:GTNG_0193.
PATRIC21976561. VBIGeoThe136879_0206.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218356.
KOK06153.
OMAAQCFALI.
OrthoDBEOG6QP13M.
ProtClustDBPRK00281.

Enzyme and pathway databases

BioCycGTHE420246:GIXT-225-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUPPP_GEOTN
AccessionPrimary (citable) accession number: A4IJS3
Entry history
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: May 1, 2007
Last modified: February 19, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families