ID   ROCA_GEOTN              Reviewed;         515 AA.
AC   A4IJP9;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 1.
DT   16-JUN-2009, entry version 18.
DE   RecName: Full=1-pyrroline-5-carboxylate dehydrogenase;
DE            Short=P5C dehydrogenase;
DE            EC=1.5.1.12;
GN   Name=rocA; OrderedLocusNames=GTNG_0169;
OS   Geobacillus thermodenitrificans (strain NG80-2).
OC   Bacteria; Firmicutes; Bacillales; Bacillaceae; Geobacillus.
OX   NCBI_TaxID=420246;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17372208; DOI=10.1073/pnas.0609650104;
RA   Feng L., Wang W., Cheng J., Ren Y., Zhao G., Gao C., Tang Y., Liu X.,
RA   Han W., Peng X., Liu R., Wang L.;
RT   "Genome and proteome of long-chain alkane degrading Geobacillus
RT   thermodenitrificans NG80-2 isolated from a deep-subsurface oil
RT   reservoir.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:5602-5607(2007).
CC   -!- CATALYTIC ACTIVITY: (S)-1-pyrroline-5-carboxylate + NAD(P)(+) + 2
CC       H(2)O = L-glutamate + NAD(P)H.
CC   -!- PATHWAY: Amino-acid degradation; L-proline degradation into L-
CC       glutamate; L-glutamate from L-proline: step 2/2.
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family. RocA
CC       subfamily.
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DR   EMBL; CP000557; ABO65553.1; -; Genomic_DNA.
DR   RefSeq; YP_001124298.1; -.
DR   GeneID; 4965022; -.
DR   GenomeReviews; CP000557_GR; GTNG_0169.
DR   KEGG; gtn:GTNG_0169; -.
DR   NMPDR; fig|420246.5.peg.171; -.
DR   OMA; A4IJP9; FSALLVK.
DR   GO; GO:0003842; F:1-pyrroline-5-carboxylate dehydrogenase act...; IEA:HAMAP.
DR   GO; GO:0006537; P:glutamate biosynthetic process; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0006561; P:proline biosynthetic process; IEA:InterPro.
DR   HAMAP; MF_00733; -; 1.
DR   InterPro; IPR016160; Ald_DH_CS.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH.
DR   InterPro; IPR005932; d-1-pyrroline-5-COlate_DH-2.
DR   Gene3D; G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.
DR   PANTHER; PTHR11699; Aldehyde_dehyd; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   TIGRFAMs; TIGR01237; D1pyr5carbox2; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   3: Inferred from homology;
KW   Complete proteome; NAD; Oxidoreductase.
FT   CHAIN         1    515       1-pyrroline-5-carboxylate dehydrogenase.
FT                                /FTId=PRO_1000045971.
FT   ACT_SITE    286    286       By similarity.
FT   ACT_SITE    320    320       By similarity.
SQ   SEQUENCE   515 AA;  56574 MW;  07C58FFA56B656FD CRC64;
     MVQPYKHEPF TDFTVDANRQ AFLAALEKVE AELGREYPLI IGGERVMTED KITSVNPANK
     AEVIGRVAKA NKELAERAMK TADEAFRTWS RTSPEARADI LFRAAAIVRR RKHEFSAWLV
     KEAGKPWREA DADTAEAIDF MEYYGRQMLK LKDGIPVESR PGETNRFFYI PLGVGVVISP
     WNFPFAIMAG TTVAALVTGN TVLLKPASAT PVVAYKFAEV LEEAGLPAGV LNYIPGSGAE
     VGDYLVEHPR TRFISFTGSR DVGIRIYERA AKVQPGQIWL KRVIAEMGGK DAIVVDKEAD
     LELAAQSIVA SAFGFSGQKC SACSRAIIVE DVYDQVLNRV VELTKQLNVG DPAEQATFMG
     PVIDQGAYNK IMEYIEIGKQ EGRLMTGGEG DDSKGFFIQP TVFADVDPNA RIMQEEIFGP
     VVAFAKARDF DHALEIANNT QYGLTGAVIS RNRANLEKAR HEFHVGNLYF NRGCTGAIVG
     YQPFGGFNMS GTDSKAGGPD YLILHMQAKT VSEMF
//