A4IJP9 (ROCA_GEOTN)
Reviewed,
UniProtKB/Swiss-Prot
Last modified
August 10, 2010.
Version 28.
History...
Customize displayNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents
Names and origin
| Protein names | Recommended name: 1-pyrroline-5-carboxylate dehydrogenase Short name=P5C dehydrogenase EC=1.5.1.12 | ||||
| Gene names |
| ||||
| Organism | Geobacillus thermodenitrificans (strain NG80-2) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 420246 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Firmicutes › Bacillales › Bacillaceae › Geobacillus |
Protein attributes
| Sequence length | 515 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Catalytic activity | (S)-1-pyrroline-5-carboxylate + NAD(P)+ + 2 H2O = L-glutamate + NAD(P)H. HAMAP MF_00733 |
| Pathway | Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 2/2. HAMAP MF_00733 |
| Sequence similarities | Belongs to the aldehyde dehydrogenase family. RocA subfamily. |
Ontologies
| Keywords | |
|---|---|
| Ligand | NAD |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW proline biosynthetic processInferred from electronic annotation. Source: InterPro |
| Molecular function | 1-pyrroline-5-carboxylate dehydrogenase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 515 | 515 | 1-pyrroline-5-carboxylate dehydrogenase HAMAP MF_00733 | PRO_1000045971 | |||||
Sites | |||||||||
| Active site | 286 | 1 | By similarity | ||||||
| Active site | 320 | 1 | By similarity | ||||||
Sequences
| ||||||||||||||||||
References
| [1] | "Genome and proteome of long-chain alkane degrading Geobacillus thermodenitrificans NG80-2 isolated from a deep-subsurface oil reservoir." Feng L., Wang W., Cheng J., Ren Y., Zhao G., Gao C., Tang Y., Liu X., Han W., Peng X., Liu R., Wang L. Proc. Natl. Acad. Sci. U.S.A. 104:5602-5607(2007) [PubMed: 17372208] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | CP000557 Genomic DNA. Translation: ABO65553.1. |
| RefSeq | YP_001124298.1. |
3D structure databases | |
| ProteinModelPortal | A4IJP9. |
| SMR | A4IJP9. Positions 2-515. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | A4IJP9. |
Genome annotation databases | |
| GeneID | 4965022. |
| GenomeReviews | Gene locus GTNG_0169 in contig CP000557_GR. |
| KEGG | gtn:GTNG_0169. |
| NMPDR | fig|420246.5.peg.171. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| eggNOG | COG1012. |
| HOGENOM | HBG752218. |
| OMA | TPYKHEP. |
| PhylomeDB | A4IJP9. |
| ProtClustDB | PRK03137. |
Enzyme and pathway databases | |
| BioCyc | GTHE420246:GTNG_0169-MONOMER. |
Family and domain databases | |
| HAMAP | MF_00733. RocA. [Tree] |
| InterPro | IPR016161. Ald_DH/histidinol_DH. IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH. IPR005932. d-1-pyrroline-5-COlate_DH-2. [Graphical view] |
| Gene3D | G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit. |
| PANTHER | PTHR11699. Aldehyde_dehyd. 1 hit. |
| Pfam | PF00171. Aldedh. 1 hit. [Graphical view] |
| SUPFAM | SSF53720. Aldehyde_DH/Histidinol_DH. 1 hit. |
| TIGRFAMs | TIGR01237. D1pyr5carbox2. 1 hit. |
| PROSITE | PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | ROCA_GEOTN | ||||||||
| Accession | Primary (citable) accession number: A4IJP9 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


