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Protein

Protein-arginine kinase

Gene

mcsB

Organism
Geobacillus thermodenitrificans (strain NG80-2)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the specific phosphorylation of arginine residues in a large number of proteins. Is part of the bacterial stress response system. Protein arginine phosphorylation has a physiologically important role and is involved in the regulation of many critical cellular processes, such as protein homeostasis, motility, competence, and stringent and stress responses, by regulating gene expression and protein activity.UniRule annotation

Catalytic activityi

ATP + a [protein]-L-arginine = ADP + a [protein]-N(omega)-phospho-L-arginine.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei92ATPUniRule annotation1
Binding sitei126ATPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi27 – 31ATPUniRule annotation5
Nucleotide bindingi177 – 181ATPUniRule annotation5
Nucleotide bindingi208 – 213ATPUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-arginine kinaseUniRule annotation (EC:2.7.14.1UniRule annotation)
Gene namesi
Name:mcsBUniRule annotation
Ordered Locus Names:GTNG_0077
OrganismiGeobacillus thermodenitrificans (strain NG80-2)
Taxonomic identifieri420246 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus
Proteomesi
  • UP000001578 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000258751 – 363Protein-arginine kinaseAdd BLAST363

Interactioni

Protein-protein interaction databases

STRINGi420246.GTNG_0077.

Structurei

3D structure databases

ProteinModelPortaliA4IJG0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 255Phosphagen kinase C-terminalUniRule annotationAdd BLAST232

Sequence similaritiesi

Belongs to the ATP:guanido phosphotransferase family.UniRule annotation
Contains 1 phosphagen kinase C-terminal domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG41066A3. Bacteria.
COG3869. LUCA.
HOGENOMiHOG000082112.
KOiK19405.
OMAiIIMQERV.
OrthoDBiPOG091H027W.

Family and domain databases

CDDicd07930. bacterial_phosphagen_kinase. 1 hit.
Gene3Di3.30.590.10. 1 hit.
HAMAPiMF_00602. Prot_Arg_kinase. 1 hit.
InterProiIPR023660. Arg_Kinase.
IPR000749. ATP-guanido_PTrfase.
IPR022415. ATP-guanido_PTrfase_AS.
IPR022414. ATP-guanido_PTrfase_cat.
IPR014746. Gln_synth/guanido_kin_cat_dom.
[Graphical view]
PANTHERiPTHR11547. PTHR11547. 2 hits.
PfamiPF00217. ATP-gua_Ptrans. 1 hit.
[Graphical view]
PROSITEiPS00112. PHOSPHAGEN_KINASE. 1 hit.
PS51510. PHOSPHAGEN_KINASE_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4IJG0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFEKFFNTA VSAWMSQEGP DSDIVLSSRI RLARNIVDFR FPTLFSSEEA
60 70 80 90 100
MQIVALFERT FAYRSYGGAG RFELLKMSEL QPIEKRVLVE KHLISPHLAE
110 120 130 140 150
DSPFGACLLS ENEEISIMIN EEDHIRIQCL FPGLQLAEAL EAASELDDWI
160 170 180 190 200
EGHVNYAFDE RLGYLTSCPT NVGTGLRASV MMHLPALVLT QQINRIIPAI
210 220 230 240 250
NQLGLVVRGT YGEGSEALGN IFQISNQLTL GKSEEDIIAD LHTIVQQLIA
260 270 280 290 300
QERAARQALV KTLGIQLEDK VFRSYGILAN CRVIESKEAA QCLSDVRLGI
310 320 330 340 350
DLGYIKNVSR NILNELMILT QPGFLQQYAG GALRPEERDV RRAALIRERL
360
KMEERRKMEG DER
Length:363
Mass (Da):40,874
Last modified:May 1, 2007 - v1
Checksum:iFE70DB1DAD1EF238
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000557 Genomic DNA. Translation: ABO65464.1.
RefSeqiWP_011886620.1. NC_009328.1.

Genome annotation databases

EnsemblBacteriaiABO65464; ABO65464; GTNG_0077.
KEGGigtn:GTNG_0077.
PATRICi21976293. VBIGeoThe136879_0082.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000557 Genomic DNA. Translation: ABO65464.1.
RefSeqiWP_011886620.1. NC_009328.1.

3D structure databases

ProteinModelPortaliA4IJG0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi420246.GTNG_0077.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABO65464; ABO65464; GTNG_0077.
KEGGigtn:GTNG_0077.
PATRICi21976293. VBIGeoThe136879_0082.

Phylogenomic databases

eggNOGiENOG41066A3. Bacteria.
COG3869. LUCA.
HOGENOMiHOG000082112.
KOiK19405.
OMAiIIMQERV.
OrthoDBiPOG091H027W.

Family and domain databases

CDDicd07930. bacterial_phosphagen_kinase. 1 hit.
Gene3Di3.30.590.10. 1 hit.
HAMAPiMF_00602. Prot_Arg_kinase. 1 hit.
InterProiIPR023660. Arg_Kinase.
IPR000749. ATP-guanido_PTrfase.
IPR022415. ATP-guanido_PTrfase_AS.
IPR022414. ATP-guanido_PTrfase_cat.
IPR014746. Gln_synth/guanido_kin_cat_dom.
[Graphical view]
PANTHERiPTHR11547. PTHR11547. 2 hits.
PfamiPF00217. ATP-gua_Ptrans. 1 hit.
[Graphical view]
PROSITEiPS00112. PHOSPHAGEN_KINASE. 1 hit.
PS51510. PHOSPHAGEN_KINASE_C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMCSB_GEOTN
AccessioniPrimary (citable) accession number: A4IJG0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 1, 2007
Last modified: November 2, 2016
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.