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Protein
Submitted name:

IP17195p

Gene

p130CAS

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • axonal defasciculation Source: FlyBase
  • cell-cell adhesion Source: FlyBase
  • cytoskeletal anchoring at plasma membrane Source: FlyBase
  • maintenance of cell polarity Source: FlyBase

Enzyme and pathway databases

ReactomeiR-DME-372708 p130Cas linkage to MAPK signaling for integrins
R-DME-4420097 VEGFA-VEGFR2 Pathway
R-DME-8849471 PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases

Names & Taxonomyi

Protein namesi
Submitted name:
IP17195pImported
Submitted name:
p130CAS, isoform DImported
Gene namesi
Name:p130CASImported
Synonyms:CT1293Imported, DCasImported, DcasImported, Dmel\CG1212Imported, p130CasImported
ORF Names:CG1212Imported, Dmel_CG1212Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0035101 p130CAS

Subcellular locationi

PTM / Processingi

Proteomic databases

PRIDEiA4IJ58

Expressioni

Gene expression databases

BgeeiFBgn0035101
ExpressionAtlasiA4IJ58 baseline and differential

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CG9098Q8T9B34EBI-15137826,EBI-15137804

Protein-protein interaction databases

IntActiA4IJ58, 2 interactors
STRINGi7227.FBpp0289142

Structurei

3D structure databases

SMRiA4IJ58
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini77 – 139SH3InterPro annotationAdd BLAST63

Keywords - Domaini

SH3 domainPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IEDD Eukaryota
ENOG410ZSUM LUCA
GeneTreeiENSGT00490000043324
KOiK16832
OMAiTVEHNQP
OrthoDBiEOG091G0YHZ

Family and domain databases

Gene3Di1.20.120.830, 1 hit
InterProiView protein in InterPro
IPR021901 CAS_C
IPR037362 CAS_fam
IPR014928 Serine_rich_dom
IPR038319 Serine_rich_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PANTHERiPTHR10654 PTHR10654, 1 hit
PfamiView protein in Pfam
PF12026 DUF3513, 1 hit
PF08824 Serine_rich, 1 hit
PF00018 SH3_1, 1 hit
SMARTiView protein in SMART
SM00326 SH3, 1 hit
SUPFAMiSSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS50002 SH3, 1 hit

Sequencei

Sequence statusi: Complete.

A4IJ58-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MECQSENRVP ENSISNVATY HTLPESQTSS VLAKHQQRQL KEPQQPPQYV
60 70 80 90 100
INSVAMHAKT TTANSITGGT LHRAKSAQKL YAKAIYDNYA DTSDELPFKK
110 120 130 140 150
GDILTVLEQD TEGFQGWWLC SLRNRQGLCP GNRLRVLNSY DSGCFSPSPA
160 170 180 190 200
SSPVPSLAAS TATLDSSICS AEIYENGSVI SAVSSSNSNS GGASSGLGSE
210 220 230 240 250
SVSRVSRRSW HASPTKVITP QRHGDVYIYN YSPGSATGSG ARAAPSTPQQ
260 270 280 290 300
QIYSNQSIYQ NFAMMSSPRQ NASGSEFETY DIPKPATPVP LNYDSPRSGL
310 320 330 340 350
PKASNSTTTS SSSLGTRFET LKSVAASIAE ESYDVPRPLI LGSNQLQQQM
360 370 380 390 400
SQMTPSSSAS SLLTSDSLSL SFSSSNRSSL ANMPDYDIPR RNPLPVRRQQ
410 420 430 440 450
SGLTYDFPLP PLQEQVPRVL CTPSTVTTTK ELPLELSSAL ETLAKLQLQT
460 470 480 490 500
TAAINRLLSF VVPNWRTRAQ LEPAIMDLKL AALRLRTTLH DLAEFGEGAL
510 520 530 540 550
GNATRSEDRN LALKLRPLVR ALRDANKLIH DSSESLDAQG AWSIDQLARS
560 570 580 590 600
DEKHGCRPPD ALDQLMVCAQ TLTEDVRSTT SFIQGNASLL FKRQLTVGHN
610 620 630 640 650
GGSGTGVLEG SRGSAEWLED YDYVAFESKD AAARKNEALR EAIPADLKTQ
660 670 680 690 700
FDTVIRTAES SAMGAGSGSI PTTPTARTTP TTPCKSPEMT DKDKKLVRYY
710 720 730 740 750
AQQISTHMGN LMQAIDSFLE TVEKNQPPKF FIAYGKFVVV SAHNLVTIGD
760 770 780 790 800
NVYRNISKEA LREKILRCTN ALSDALKTCV LKSKKAAAHF PSGSAVQEMV
810 820 830
DSVVHINNLA RDLKSVMLQA VHLSTAAGVG A
Length:831
Mass (Da):89,944
Last modified:May 1, 2007 - v1
Checksum:i48C8B8577A2218F8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT030416 mRNA Translation: ABO52836.1
AE014296 Genomic DNA Translation: ABW08421.2
RefSeqiNP_001097456.2, NM_001103986.3
UniGeneiDm.792

Genome annotation databases

EnsemblMetazoaiFBtr0299864; FBpp0289142; FBgn0035101
GeneIDi38021
KEGGidme:Dmel_CG1212

Similar proteinsi

Entry informationi

Entry nameiA4IJ58_DROME
AccessioniPrimary (citable) accession number: A4IJ58
Secondary accession number(s): A8JNG5
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2007
Last sequence update: May 1, 2007
Last modified: May 23, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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