ID CDK14_XENTR Reviewed; 423 AA. AC A4IIW7; DT 02-MAR-2010, integrated into UniProtKB/Swiss-Prot. DT 01-MAY-2007, sequence version 1. DT 27-MAR-2024, entry version 82. DE RecName: Full=Cyclin-dependent kinase 14; DE EC=2.7.11.22; DE AltName: Full=Cell division protein kinase 14; GN Name=cdk14; Synonyms=pftk1; OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana. OX NCBI_TaxID=8364; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Brain; RG NIH - Xenopus Gene Collection (XGC) project; RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Serine/threonine-protein kinase involved in the control of CC the eukaryotic cell cycle, whose activity is controlled by an CC associated cyclin. Acts as a cell-cycle regulator of Wnt signaling CC pathway during G2/M phase by mediating the phosphorylation of lrp6, CC leading to the activation of the Wnt signaling pathway (By similarity). CC {ECO:0000250}. CC -!- CATALYTIC ACTIVITY: CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.22; CC -!- CATALYTIC ACTIVITY: CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; CC EC=2.7.11.22; CC -!- SUBUNIT: Interacts with ccny; ccny mediates its recruitment to the CC plasma membrane and promotes phosphorylation of lrp6. {ECO:0000250}. CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Peripheral membrane CC protein {ECO:0000250}. Note=Recruited to the cell membrane by CCNY. CC {ECO:0000250}. CC -!- SIMILARITY: Belongs to the protein kinase superfamily. CMGC Ser/Thr CC protein kinase family. CDC2/CDKX subfamily. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC136183; AAI36184.1; -; mRNA. DR RefSeq; NP_001096458.1; NM_001102988.1. DR AlphaFoldDB; A4IIW7; -. DR SMR; A4IIW7; -. DR STRING; 8364.ENSXETP00000021459; -. DR PaxDb; 8364-ENSXETP00000007502; -. DR DNASU; 100125075; -. DR Ensembl; ENSXETT00000007502; ENSXETP00000007502; ENSXETG00000003466. DR GeneID; 100125075; -. DR KEGG; xtr:100125075; -. DR AGR; Xenbase:XB-GENE-943250; -. DR CTD; 5218; -. DR Xenbase; XB-GENE-943250; cdk14. DR eggNOG; KOG0594; Eukaryota. DR HOGENOM; CLU_000288_181_6_1; -. DR InParanoid; A4IIW7; -. DR OrthoDB; 244018at2759; -. DR Proteomes; UP000008143; Chromosome 6. DR Bgee; ENSXETG00000003466; Expressed in brain and 9 other cell types or tissues. DR ExpressionAtlas; A4IIW7; baseline and differential. DR GO; GO:0000308; C:cytoplasmic cyclin-dependent protein kinase holoenzyme complex; ISS:UniProtKB. DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0004693; F:cyclin-dependent protein serine/threonine kinase activity; ISS:UniProtKB. DR GO; GO:0106310; F:protein serine kinase activity; IEA:RHEA. DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW. DR GO; GO:0000086; P:G2/M transition of mitotic cell cycle; ISS:UniProtKB. DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW. DR GO; GO:0060828; P:regulation of canonical Wnt signaling pathway; ISS:UniProtKB. DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW. DR CDD; cd07869; STKc_PFTAIRE1; 1. DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1. DR InterPro; IPR011009; Kinase-like_dom_sf. DR InterPro; IPR000719; Prot_kinase_dom. DR InterPro; IPR017441; Protein_kinase_ATP_BS. DR InterPro; IPR008271; Ser/Thr_kinase_AS. DR PANTHER; PTHR24056; CELL DIVISION PROTEIN KINASE; 1. DR PANTHER; PTHR24056:SF154; CYCLIN-DEPENDENT KINASE 14; 1. DR Pfam; PF00069; Pkinase; 1. DR SMART; SM00220; S_TKc; 1. DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1. DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1. DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1. DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1. PE 2: Evidence at transcript level; KW ATP-binding; Cell cycle; Cell division; Cell membrane; Kinase; Membrane; KW Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; KW Transferase; Wnt signaling pathway. FT CHAIN 1..423 FT /note="Cyclin-dependent kinase 14" FT /id="PRO_0000391904" FT DOMAIN 89..373 FT /note="Protein kinase" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" FT REGION 62..85 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT ACT_SITE 210 FT /note="Proton acceptor" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, FT ECO:0000255|PROSITE-ProRule:PRU10027" FT BINDING 95..103 FT /ligand="ATP" FT /ligand_id="ChEBI:CHEBI:30616" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" FT BINDING 118 FT /ligand="ATP" FT /ligand_id="ChEBI:CHEBI:30616" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159" SQ SEQUENCE 423 AA; 47680 MW; 4D229A5E1558FDB5 CRC64; MSTRNCQGID SVIKPLDTIP EDKKVRVQRT QSSFDPFEKT SNQVKRVHSE NNACINFKSA SVGKESPKVR RHSSPSSPTS PKFGKADSYE KLEKLGEGSY ATVYKGKSKV NGKLVALKVI RLQEEEGTPF TAIREASLLK GLKHANIVLL HDIIHTKETL TLVFEYVHTD LCQYMDKHPG GLNPENVKLF LFQLLRGLSY IHQGHILHRD LKPQNLLISD TGELKLADFG LARAKSVPSH TYSNEVVTLW YRPPDVLLGS TDYSTCLDMW GVGCIFVEMI QGVAAFPGMK DIQDQLERIF LILGTPNEET WPGVHSLPHF KLERFTQYGP KNLRQAWNKL SYVNHAEDLA SKLLQCFPKN RLSAQAALNH DYFSDLPPRL WELSDMSSIF TVPNVKLQPE AGESMRVFGK NNSFSKSLSN SKH //