A4IIW7 (CDK14_XENTR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cyclin-dependent kinase 14
EC=2.7.11.22

Alternative name(s):
Cell division protein kinase 14

Gene names

Name:	cdk14
Synonyms:	pftk1

Organism

Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) [Reference proteome]

Taxonomic identifier

8364 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana

Protein attributes

Sequence length	423 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of lrp6, leading to the activation of the Wnt signaling pathway By similarity.
Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Subunit structure	Interacts with ccny; ccny mediates its recruitment to the plasma membrane and promotes phosphorylation of lrp6 By similarity.
Subcellular location	Cell membrane; Peripheral membrane protein By similarity. Note: Recruited to the cell membrane by CCNY By similarity.
Sequence similarities	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. Contains 1 protein kinase domain.

Ontologies

Keywords
Biological process	Cell cycle Cell division Wnt signaling pathway
Cellular component	Cell membrane Membrane
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	G2/M transition of mitotic cell cycle Inferred from sequence or structural similarity. Source: UniProtKB Wnt receptor signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW cell division Inferred from electronic annotation. Source: UniProtKB-KW regulation of canonical Wnt receptor signaling pathway Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	cytoplasmic cyclin-dependent protein kinase holoenzyme complex Inferred from sequence or structural similarity. Source: UniProtKB plasma membrane Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW cyclin-dependent protein serine/threonine kinase activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 423	423	Cyclin-dependent kinase 14		PRO_0000391904
Regions
	Domain	89 – 373	285	Protein kinase
	Nucleotide binding	95 – 103	9	ATP By similarity
Sites
	Active site	210	1	Proton acceptor By similarity
	Binding site	118	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	A4IIW7 [UniParc]. Last modified May 1, 2007. Version 1. Checksum: 4D229A5E1558FDB5	FASTA	423	47,680
	10 20 30 40 50 60 MSTRNCQGID SVIKPLDTIP EDKKVRVQRT QSSFDPFEKT SNQVKRVHSE NNACINFKSA 70 80 90 100 110 120 SVGKESPKVR RHSSPSSPTS PKFGKADSYE KLEKLGEGSY ATVYKGKSKV NGKLVALKVI 130 140 150 160 170 180 RLQEEEGTPF TAIREASLLK GLKHANIVLL HDIIHTKETL TLVFEYVHTD LCQYMDKHPG 190 200 210 220 230 240 GLNPENVKLF LFQLLRGLSY IHQGHILHRD LKPQNLLISD TGELKLADFG LARAKSVPSH 250 260 270 280 290 300 TYSNEVVTLW YRPPDVLLGS TDYSTCLDMW GVGCIFVEMI QGVAAFPGMK DIQDQLERIF 310 320 330 340 350 360 LILGTPNEET WPGVHSLPHF KLERFTQYGP KNLRQAWNKL SYVNHAEDLA SKLLQCFPKN 370 380 390 400 410 420 RLSAQAALNH DYFSDLPPRL WELSDMSSIF TVPNVKLQPE AGESMRVFGK NNSFSKSLSN SKH

References

[1]	NIH - Xenopus Gene Collection (XGC) project Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC136183 mRNA. Translation: AAI36184.1.
RefSeq	NP_001096458.1. NM_001102988.1.
UniGene	Str.20988.
3D structure databases
ProteinModelPortal	A4IIW7.
SMR	A4IIW7. Positions 89-376.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	100125075.
KEGG	xtr:100125075.
Organism-specific databases
CTD	5218.
Xenbase	XB-GENE-943250. cdk14.
Phylogenomic databases
eggNOG	COG0515.
HOVERGEN	HBG014652.
KO	K08821.
Gene expression databases
Bgee	A4IIW7.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR002290. Ser/Thr_dual-sp_kinase_dom. IPR008271. Ser/Thr_kinase_AS. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
SMART	SM00220. S_TKc. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CDK14_XENTR

Accession

Primary (citable) accession number: A4IIW7

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 2, 2010
Last sequence update:	May 1, 2007
Last modified:	May 1, 2013
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program