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A4IIW7

- CDK14_XENTR

UniProt

A4IIW7 - CDK14_XENTR

Protein

Cyclin-dependent kinase 14

Gene

cdk14

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (01 May 2007)
      Previous versions | rss
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    Functioni

    Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of lrp6, leading to the activation of the Wnt signaling pathway By similarity.By similarity

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei118 – 1181ATPPROSITE-ProRule annotation
    Active sitei210 – 2101Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi95 – 1039ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB

    GO - Biological processi

    1. cell division Source: UniProtKB-KW
    2. G2/M transition of mitotic cell cycle Source: UniProtKB
    3. regulation of canonical Wnt signaling pathway Source: UniProtKB
    4. regulation of cell cycle Source: GOC
    5. Wnt signaling pathway Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Biological processi

    Cell cycle, Cell division, Wnt signaling pathway

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cyclin-dependent kinase 14 (EC:2.7.11.22)
    Alternative name(s):
    Cell division protein kinase 14
    Gene namesi
    Name:cdk14
    Synonyms:pftk1
    OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
    Taxonomic identifieri8364 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
    ProteomesiUP000008143: Unplaced

    Organism-specific databases

    XenbaseiXB-GENE-943250. cdk14.

    Subcellular locationi

    Cell membrane By similarity; Peripheral membrane protein By similarity
    Note: Recruited to the cell membrane by CCNY.By similarity

    GO - Cellular componenti

    1. cytoplasmic cyclin-dependent protein kinase holoenzyme complex Source: UniProtKB
    2. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 423423Cyclin-dependent kinase 14PRO_0000391904Add
    BLAST

    Expressioni

    Gene expression databases

    BgeeiA4IIW7.

    Interactioni

    Subunit structurei

    Interacts with ccny; ccny mediates its recruitment to the plasma membrane and promotes phosphorylation of lrp6.By similarity

    Protein-protein interaction databases

    STRINGi8364.ENSXETP00000007502.

    Structurei

    3D structure databases

    ProteinModelPortaliA4IIW7.
    SMRiA4IIW7. Positions 89-376.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini89 – 373285Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    HOVERGENiHBG014652.
    KOiK08821.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A4IIW7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSTRNCQGID SVIKPLDTIP EDKKVRVQRT QSSFDPFEKT SNQVKRVHSE    50
    NNACINFKSA SVGKESPKVR RHSSPSSPTS PKFGKADSYE KLEKLGEGSY 100
    ATVYKGKSKV NGKLVALKVI RLQEEEGTPF TAIREASLLK GLKHANIVLL 150
    HDIIHTKETL TLVFEYVHTD LCQYMDKHPG GLNPENVKLF LFQLLRGLSY 200
    IHQGHILHRD LKPQNLLISD TGELKLADFG LARAKSVPSH TYSNEVVTLW 250
    YRPPDVLLGS TDYSTCLDMW GVGCIFVEMI QGVAAFPGMK DIQDQLERIF 300
    LILGTPNEET WPGVHSLPHF KLERFTQYGP KNLRQAWNKL SYVNHAEDLA 350
    SKLLQCFPKN RLSAQAALNH DYFSDLPPRL WELSDMSSIF TVPNVKLQPE 400
    AGESMRVFGK NNSFSKSLSN SKH 423
    Length:423
    Mass (Da):47,680
    Last modified:May 1, 2007 - v1
    Checksum:i4D229A5E1558FDB5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC136183 mRNA. Translation: AAI36184.1.
    RefSeqiNP_001096458.1. NM_001102988.1.
    UniGeneiStr.20988.

    Genome annotation databases

    GeneIDi100125075.
    KEGGixtr:100125075.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC136183 mRNA. Translation: AAI36184.1 .
    RefSeqi NP_001096458.1. NM_001102988.1.
    UniGenei Str.20988.

    3D structure databases

    ProteinModelPortali A4IIW7.
    SMRi A4IIW7. Positions 89-376.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 8364.ENSXETP00000007502.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100125075.
    KEGGi xtr:100125075.

    Organism-specific databases

    CTDi 5218.
    Xenbasei XB-GENE-943250. cdk14.

    Phylogenomic databases

    eggNOGi COG0515.
    HOVERGENi HBG014652.
    KOi K08821.

    Gene expression databases

    Bgeei A4IIW7.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Xenopus Gene Collection (XGC) project
      Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiCDK14_XENTR
    AccessioniPrimary (citable) accession number: A4IIW7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 2, 2010
    Last sequence update: May 1, 2007
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3