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A4IIW7

- CDK14_XENTR

UniProt

A4IIW7 - CDK14_XENTR

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Protein
Cyclin-dependent kinase 14
Gene
cdk14, pftk1
Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of lrp6, leading to the activation of the Wnt signaling pathway By similarity.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei118 – 1181ATP By similarity
Active sitei210 – 2101Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi95 – 1039ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB

GO - Biological processi

  1. G2/M transition of mitotic cell cycle Source: UniProtKB
  2. Wnt signaling pathway Source: UniProtKB-KW
  3. cell division Source: UniProtKB-KW
  4. regulation of canonical Wnt signaling pathway Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Cell cycle, Cell division, Wnt signaling pathway

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase 14 (EC:2.7.11.22)
Alternative name(s):
Cell division protein kinase 14
Gene namesi
Name:cdk14
Synonyms:pftk1
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
ProteomesiUP000008143: Unplaced

Organism-specific databases

XenbaseiXB-GENE-943250. cdk14.

Subcellular locationi

Cell membrane; Peripheral membrane protein By similarity
Note: Recruited to the cell membrane by CCNY By similarity.

GO - Cellular componenti

  1. cytoplasmic cyclin-dependent protein kinase holoenzyme complex Source: UniProtKB
  2. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 423423Cyclin-dependent kinase 14
PRO_0000391904Add
BLAST

Expressioni

Gene expression databases

BgeeiA4IIW7.

Interactioni

Subunit structurei

Interacts with ccny; ccny mediates its recruitment to the plasma membrane and promotes phosphorylation of lrp6 By similarity.

Protein-protein interaction databases

STRINGi8364.ENSXETP00000007502.

Structurei

3D structure databases

ProteinModelPortaliA4IIW7.
SMRiA4IIW7. Positions 89-376.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini89 – 373285Protein kinase
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0515.
HOVERGENiHBG014652.
KOiK08821.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4IIW7-1 [UniParc]FASTAAdd to Basket

« Hide

MSTRNCQGID SVIKPLDTIP EDKKVRVQRT QSSFDPFEKT SNQVKRVHSE    50
NNACINFKSA SVGKESPKVR RHSSPSSPTS PKFGKADSYE KLEKLGEGSY 100
ATVYKGKSKV NGKLVALKVI RLQEEEGTPF TAIREASLLK GLKHANIVLL 150
HDIIHTKETL TLVFEYVHTD LCQYMDKHPG GLNPENVKLF LFQLLRGLSY 200
IHQGHILHRD LKPQNLLISD TGELKLADFG LARAKSVPSH TYSNEVVTLW 250
YRPPDVLLGS TDYSTCLDMW GVGCIFVEMI QGVAAFPGMK DIQDQLERIF 300
LILGTPNEET WPGVHSLPHF KLERFTQYGP KNLRQAWNKL SYVNHAEDLA 350
SKLLQCFPKN RLSAQAALNH DYFSDLPPRL WELSDMSSIF TVPNVKLQPE 400
AGESMRVFGK NNSFSKSLSN SKH 423
Length:423
Mass (Da):47,680
Last modified:May 1, 2007 - v1
Checksum:i4D229A5E1558FDB5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC136183 mRNA. Translation: AAI36184.1.
RefSeqiNP_001096458.1. NM_001102988.1.
UniGeneiStr.20988.

Genome annotation databases

GeneIDi100125075.
KEGGixtr:100125075.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC136183 mRNA. Translation: AAI36184.1 .
RefSeqi NP_001096458.1. NM_001102988.1.
UniGenei Str.20988.

3D structure databases

ProteinModelPortali A4IIW7.
SMRi A4IIW7. Positions 89-376.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 8364.ENSXETP00000007502.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100125075.
KEGGi xtr:100125075.

Organism-specific databases

CTDi 5218.
Xenbasei XB-GENE-943250. cdk14.

Phylogenomic databases

eggNOGi COG0515.
HOVERGENi HBG014652.
KOi K08821.

Gene expression databases

Bgeei A4IIW7.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiCDK14_XENTR
AccessioniPrimary (citable) accession number: A4IIW7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 2, 2010
Last sequence update: May 1, 2007
Last modified: March 19, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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