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A4IIW7

- CDK14_XENTR

UniProt

A4IIW7 - CDK14_XENTR

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Protein

Cyclin-dependent kinase 14

Gene

cdk14

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of lrp6, leading to the activation of the Wnt signaling pathway (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei118 – 1181ATPPROSITE-ProRule annotation
Active sitei210 – 2101Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi95 – 1039ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB

GO - Biological processi

  1. cell division Source: UniProtKB-KW
  2. G2/M transition of mitotic cell cycle Source: UniProtKB
  3. regulation of canonical Wnt signaling pathway Source: UniProtKB
  4. regulation of cell cycle Source: GOC
  5. Wnt signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Cell cycle, Cell division, Wnt signaling pathway

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase 14 (EC:2.7.11.22)
Alternative name(s):
Cell division protein kinase 14
Gene namesi
Name:cdk14
Synonyms:pftk1
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
ProteomesiUP000008143: Unplaced

Organism-specific databases

XenbaseiXB-GENE-943250. cdk14.

Subcellular locationi

Cell membrane By similarity; Peripheral membrane protein By similarity
Note: Recruited to the cell membrane by CCNY.By similarity

GO - Cellular componenti

  1. cytoplasmic cyclin-dependent protein kinase holoenzyme complex Source: UniProtKB
  2. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 423423Cyclin-dependent kinase 14PRO_0000391904Add
BLAST

Expressioni

Gene expression databases

BgeeiA4IIW7.
ExpressionAtlasiA4IIW7. baseline.

Interactioni

Subunit structurei

Interacts with ccny; ccny mediates its recruitment to the plasma membrane and promotes phosphorylation of lrp6.By similarity

Protein-protein interaction databases

STRINGi8364.ENSXETP00000007502.

Structurei

3D structure databases

ProteinModelPortaliA4IIW7.
SMRiA4IIW7. Positions 89-376.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini89 – 373285Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
HOVERGENiHBG014652.
InParanoidiA4IIW7.
KOiK08821.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4IIW7 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSTRNCQGID SVIKPLDTIP EDKKVRVQRT QSSFDPFEKT SNQVKRVHSE
60 70 80 90 100
NNACINFKSA SVGKESPKVR RHSSPSSPTS PKFGKADSYE KLEKLGEGSY
110 120 130 140 150
ATVYKGKSKV NGKLVALKVI RLQEEEGTPF TAIREASLLK GLKHANIVLL
160 170 180 190 200
HDIIHTKETL TLVFEYVHTD LCQYMDKHPG GLNPENVKLF LFQLLRGLSY
210 220 230 240 250
IHQGHILHRD LKPQNLLISD TGELKLADFG LARAKSVPSH TYSNEVVTLW
260 270 280 290 300
YRPPDVLLGS TDYSTCLDMW GVGCIFVEMI QGVAAFPGMK DIQDQLERIF
310 320 330 340 350
LILGTPNEET WPGVHSLPHF KLERFTQYGP KNLRQAWNKL SYVNHAEDLA
360 370 380 390 400
SKLLQCFPKN RLSAQAALNH DYFSDLPPRL WELSDMSSIF TVPNVKLQPE
410 420
AGESMRVFGK NNSFSKSLSN SKH
Length:423
Mass (Da):47,680
Last modified:May 1, 2007 - v1
Checksum:i4D229A5E1558FDB5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC136183 mRNA. Translation: AAI36184.1.
RefSeqiNP_001096458.1. NM_001102988.1.
UniGeneiStr.20988.

Genome annotation databases

GeneIDi100125075.
KEGGixtr:100125075.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC136183 mRNA. Translation: AAI36184.1 .
RefSeqi NP_001096458.1. NM_001102988.1.
UniGenei Str.20988.

3D structure databases

ProteinModelPortali A4IIW7.
SMRi A4IIW7. Positions 89-376.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 8364.ENSXETP00000007502.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100125075.
KEGGi xtr:100125075.

Organism-specific databases

CTDi 5218.
Xenbasei XB-GENE-943250. cdk14.

Phylogenomic databases

eggNOGi COG0515.
HOVERGENi HBG014652.
InParanoidi A4IIW7.
KOi K08821.

Gene expression databases

Bgeei A4IIW7.
ExpressionAtlasi A4IIW7. baseline.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiCDK14_XENTR
AccessioniPrimary (citable) accession number: A4IIW7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 2, 2010
Last sequence update: May 1, 2007
Last modified: October 29, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3