A4IIS8S47A1_XENTRMultidrug and toxin extrusion protein 1MATE-1Solute carrier family 47 member 1slc47a1mate1Xenopus tropicalisWestern clawed frogSilurana tropicalisEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSiluranaNUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]Multidrug efflux pump that functions as a H(+)/organic cation antiporter. Mediates the secretion of cationic compounds including drugs, toxins and endogenous metabolites. Plays a role physiological role in the excretion of drugs, toxins and endogenous metabolites through the kidney and liver, into urine and bile respectively.H(+)(in) + thiamine(out) = H(+)(out) + thiamine(in)estrone 3-sulfate(in) + H(+)(out) = estrone 3-sulfate(out) + H(+)(in)creatinine(in) + H(+)(out) = creatinine(out) + H(+)(in)agmatine(in) + H(+)(out) = agmatine(out) + H(+)(in)Cell membraneMulti-pass membrane proteinApical cell membraneMulti-pass membrane proteinLocalizes to the plasma membrane; at the brush border membranes of the proximal tubules (kidney) and at the bile caniculi (liver).Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.Cell membraneMembraneReference proteomeTransmembraneTransmembrane helixTransportMEGQAAETNHRAETVVRAELCLSAEQGPETTAYSQKRCLFLPMEVWQEAQQLLALAAPAFLSQLMIFLISIVSSIFCGHLGKVELDAVSLAITIINITGVAVGTGLAGACDTLISQTFGGSNLKLVGIILQRGILILLLFCFPCWALLINTESILLLFRQDPEVSKLTQIYVLIFLPALPAAFLYQLLAKYLQNQGIIYPQVLTGFIANIFNALFNYILLYVLGLGVMGSACANTVSQFIQMILLFLYIVWRRLYADTWGGWSQACFEEWGAFIRLAVASMLMLCIEWWAFEISMFLAGVLGMVDLAAQAIIYQVAIVVYLIPLGLCIAGSIRVGHGLGAGNTEQAKRSALVVLCMTELCALLSGILLATLKDVVAYIFTSDPNIVALVSYVLPVYSACLLFDACVAACGGILRGSGKLKVGAISHTVGYYVIGLPLGISLMFAAKLGIIGFWFGILACGIAQSIFLIIFVFKIDWKRASEEAQTRASERVEIPQKIDNKPSVYQEGCPTEQGDVDPGNVESIEFSQSSTSSEGTSPTPAGAAQHTRTLILTRGLALGCAVGTLIIGIVIRLSV
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