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A4IIS8

- S47A1_XENTR

UniProt

A4IIS8 - S47A1_XENTR

Protein

Multidrug and toxin extrusion protein 1

Gene

slc47a1

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 42 (01 Oct 2014)
      Sequence version 1 (01 May 2007)
      Previous versions | rss
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    Functioni

    Solute transporter for tetraethylammonium (TEA), cimetidine, metformin, guanidine, N-methylnicotinamide (NMN) and also the zwitterionic cephalosporin cephalexin. Responsible for the secretion of cationic drugs across the brush border membranes By similarity.By similarity

    GO - Molecular functioni

    1. antiporter activity Source: InterPro
    2. drug transmembrane transporter activity Source: InterPro

    Keywords - Biological processi

    Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Multidrug and toxin extrusion protein 1
    Short name:
    MATE-1
    Alternative name(s):
    Solute carrier family 47 member 1
    Gene namesi
    Name:slc47a1
    Synonyms:mate1
    OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
    Taxonomic identifieri8364 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
    ProteomesiUP000008143: Unplaced

    Organism-specific databases

    XenbaseiXB-GENE-5793831. slc47a2.

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 574574Multidrug and toxin extrusion protein 1PRO_0000312851Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi8364.ENSXETP00000049598.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 5151CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini73 – 8614ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini108 – 13326CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini155 – 16814ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini190 – 20415CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini226 – 2305ExtracellularSequence Analysis
    Topological domaini252 – 27120CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini292 – 30918ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini331 – 35020CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini372 – 38413ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini406 – 43025CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini452 – 4532ExtracellularSequence Analysis
    Topological domaini473 – 54977CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini571 – 5744ExtracellularSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei52 – 7221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei87 – 10721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei134 – 15421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei169 – 18921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei205 – 22521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei231 – 25121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei272 – 29120HelicalSequence AnalysisAdd
    BLAST
    Transmembranei310 – 33021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei351 – 37121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei385 – 40521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei431 – 45121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei454 – 47219HelicalSequence AnalysisAdd
    BLAST
    Transmembranei550 – 57021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0534.
    HOGENOMiHOG000060313.
    HOVERGENiHBG056043.
    KOiK03327.

    Family and domain databases

    InterProiIPR002528. MATE.
    [Graphical view]
    PfamiPF01554. MatE. 2 hits.
    [Graphical view]
    TIGRFAMsiTIGR00797. matE. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A4IIS8-1 [UniParc]FASTAAdd to Basket

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    MEGQAAETNH RAETVVRAEL CLSAEQGPET TAYSQKRCLF LPMEVWQEAQ    50
    QLLALAAPAF LSQLMIFLIS IVSSIFCGHL GKVELDAVSL AITIINITGV 100
    AVGTGLAGAC DTLISQTFGG SNLKLVGIIL QRGILILLLF CFPCWALLIN 150
    TESILLLFRQ DPEVSKLTQI YVLIFLPALP AAFLYQLLAK YLQNQGIIYP 200
    QVLTGFIANI FNALFNYILL YVLGLGVMGS ACANTVSQFI QMILLFLYIV 250
    WRRLYADTWG GWSQACFEEW GAFIRLAVAS MLMLCIEWWA FEISMFLAGV 300
    LGMVDLAAQA IIYQVAIVVY LIPLGLCIAG SIRVGHGLGA GNTEQAKRSA 350
    LVVLCMTELC ALLSGILLAT LKDVVAYIFT SDPNIVALVS YVLPVYSACL 400
    LFDACVAACG GILRGSGKLK VGAISHTVGY YVIGLPLGIS LMFAAKLGII 450
    GFWFGILACG IAQSIFLIIF VFKIDWKRAS EEAQTRASER VEIPQKIDNK 500
    PSVYQEGCPT EQGDVDPGNV ESIEFSQSST SSEGTSPTPA GAAQHTRTLI 550
    LTRGLALGCA VGTLIIGIVI RLSV 574
    Length:574
    Mass (Da):61,887
    Last modified:May 1, 2007 - v1
    Checksum:iCDC2BA5D2D406B15
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC136138 mRNA. Translation: AAI36139.1.
    RefSeqiNP_001096440.1. NM_001102970.1.
    UniGeneiStr.64530.

    Genome annotation databases

    GeneIDi100125051.
    KEGGixtr:100125051.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC136138 mRNA. Translation: AAI36139.1 .
    RefSeqi NP_001096440.1. NM_001102970.1.
    UniGenei Str.64530.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 8364.ENSXETP00000049598.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100125051.
    KEGGi xtr:100125051.

    Organism-specific databases

    CTDi 146802.
    Xenbasei XB-GENE-5793831. slc47a2.

    Phylogenomic databases

    eggNOGi COG0534.
    HOGENOMi HOG000060313.
    HOVERGENi HBG056043.
    KOi K03327.

    Family and domain databases

    InterProi IPR002528. MATE.
    [Graphical view ]
    Pfami PF01554. MatE. 2 hits.
    [Graphical view ]
    TIGRFAMsi TIGR00797. matE. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. NIH - Xenopus Gene Collection (XGC) project
      Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiS47A1_XENTR
    AccessioniPrimary (citable) accession number: A4IIS8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 4, 2007
    Last sequence update: May 1, 2007
    Last modified: October 1, 2014
    This is version 42 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3