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A4IIS8

- S47A1_XENTR

UniProt

A4IIS8 - S47A1_XENTR

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Protein
Multidrug and toxin extrusion protein 1
Gene
slc47a1, mate1
Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Solute transporter for tetraethylammonium (TEA), cimetidine, metformin, guanidine, N-methylnicotinamide (NMN) and also the zwitterionic cephalosporin cephalexin. Responsible for the secretion of cationic drugs across the brush border membranes By similarity.

GO - Molecular functioni

  1. antiporter activity Source: InterPro
  2. drug transmembrane transporter activity Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Multidrug and toxin extrusion protein 1
Short name:
MATE-1
Alternative name(s):
Solute carrier family 47 member 1
Gene namesi
Name:slc47a1
Synonyms:mate1
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
ProteomesiUP000008143: Unplaced

Organism-specific databases

XenbaseiXB-GENE-5793831. slc47a2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5151Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei52 – 7221Helical; Reviewed prediction
Add
BLAST
Topological domaini73 – 8614Extracellular Reviewed prediction
Add
BLAST
Transmembranei87 – 10721Helical; Reviewed prediction
Add
BLAST
Topological domaini108 – 13326Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei134 – 15421Helical; Reviewed prediction
Add
BLAST
Topological domaini155 – 16814Extracellular Reviewed prediction
Add
BLAST
Transmembranei169 – 18921Helical; Reviewed prediction
Add
BLAST
Topological domaini190 – 20415Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei205 – 22521Helical; Reviewed prediction
Add
BLAST
Topological domaini226 – 2305Extracellular Reviewed prediction
Transmembranei231 – 25121Helical; Reviewed prediction
Add
BLAST
Topological domaini252 – 27120Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei272 – 29120Helical; Reviewed prediction
Add
BLAST
Topological domaini292 – 30918Extracellular Reviewed prediction
Add
BLAST
Transmembranei310 – 33021Helical; Reviewed prediction
Add
BLAST
Topological domaini331 – 35020Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei351 – 37121Helical; Reviewed prediction
Add
BLAST
Topological domaini372 – 38413Extracellular Reviewed prediction
Add
BLAST
Transmembranei385 – 40521Helical; Reviewed prediction
Add
BLAST
Topological domaini406 – 43025Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei431 – 45121Helical; Reviewed prediction
Add
BLAST
Topological domaini452 – 4532Extracellular Reviewed prediction
Transmembranei454 – 47219Helical; Reviewed prediction
Add
BLAST
Topological domaini473 – 54977Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei550 – 57021Helical; Reviewed prediction
Add
BLAST
Topological domaini571 – 5744Extracellular Reviewed prediction

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 574574Multidrug and toxin extrusion protein 1
PRO_0000312851Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000049598.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0534.
HOGENOMiHOG000060313.
HOVERGENiHBG056043.
KOiK03327.

Family and domain databases

InterProiIPR002528. MATE.
[Graphical view]
PfamiPF01554. MatE. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00797. matE. 1 hit.

Sequencei

Sequence statusi: Complete.

A4IIS8-1 [UniParc]FASTAAdd to Basket

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MEGQAAETNH RAETVVRAEL CLSAEQGPET TAYSQKRCLF LPMEVWQEAQ    50
QLLALAAPAF LSQLMIFLIS IVSSIFCGHL GKVELDAVSL AITIINITGV 100
AVGTGLAGAC DTLISQTFGG SNLKLVGIIL QRGILILLLF CFPCWALLIN 150
TESILLLFRQ DPEVSKLTQI YVLIFLPALP AAFLYQLLAK YLQNQGIIYP 200
QVLTGFIANI FNALFNYILL YVLGLGVMGS ACANTVSQFI QMILLFLYIV 250
WRRLYADTWG GWSQACFEEW GAFIRLAVAS MLMLCIEWWA FEISMFLAGV 300
LGMVDLAAQA IIYQVAIVVY LIPLGLCIAG SIRVGHGLGA GNTEQAKRSA 350
LVVLCMTELC ALLSGILLAT LKDVVAYIFT SDPNIVALVS YVLPVYSACL 400
LFDACVAACG GILRGSGKLK VGAISHTVGY YVIGLPLGIS LMFAAKLGII 450
GFWFGILACG IAQSIFLIIF VFKIDWKRAS EEAQTRASER VEIPQKIDNK 500
PSVYQEGCPT EQGDVDPGNV ESIEFSQSST SSEGTSPTPA GAAQHTRTLI 550
LTRGLALGCA VGTLIIGIVI RLSV 574
Length:574
Mass (Da):61,887
Last modified:May 1, 2007 - v1
Checksum:iCDC2BA5D2D406B15
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC136138 mRNA. Translation: AAI36139.1.
RefSeqiNP_001096440.1. NM_001102970.1.
UniGeneiStr.64530.

Genome annotation databases

GeneIDi100125051.
KEGGixtr:100125051.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC136138 mRNA. Translation: AAI36139.1 .
RefSeqi NP_001096440.1. NM_001102970.1.
UniGenei Str.64530.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 8364.ENSXETP00000049598.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100125051.
KEGGi xtr:100125051.

Organism-specific databases

CTDi 146802.
Xenbasei XB-GENE-5793831. slc47a2.

Phylogenomic databases

eggNOGi COG0534.
HOGENOMi HOG000060313.
HOVERGENi HBG056043.
KOi K03327.

Family and domain databases

InterProi IPR002528. MATE.
[Graphical view ]
Pfami PF01554. MatE. 2 hits.
[Graphical view ]
TIGRFAMsi TIGR00797. matE. 1 hit.
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiS47A1_XENTR
AccessioniPrimary (citable) accession number: A4IIS8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: May 1, 2007
Last modified: March 19, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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