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A4IIS8 (S47A1_XENTR) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Multidrug and toxin extrusion protein 1

Short name=MATE-1
Alternative name(s):
Solute carrier family 47 member 1
Gene names
Name:slc47a1
Synonyms:mate1
OrganismXenopus tropicalis (Western clawed frog) (Silurana tropicalis) [Reference proteome]
Taxonomic identifier8364 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana

Protein attributes

Sequence length574 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Solute transporter for tetraethylammonium (TEA), cimetidine, metformin, guanidine, N-methylnicotinamide (NMN) and also the zwitterionic cephalosporin cephalexin. Responsible for the secretion of cationic drugs across the brush border membranes By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. [View classification]

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 574574Multidrug and toxin extrusion protein 1
PRO_0000312851

Regions

Topological domain1 – 5151Cytoplasmic Potential
Transmembrane52 – 7221Helical; Potential
Topological domain73 – 8614Extracellular Potential
Transmembrane87 – 10721Helical; Potential
Topological domain108 – 13326Cytoplasmic Potential
Transmembrane134 – 15421Helical; Potential
Topological domain155 – 16814Extracellular Potential
Transmembrane169 – 18921Helical; Potential
Topological domain190 – 20415Cytoplasmic Potential
Transmembrane205 – 22521Helical; Potential
Topological domain226 – 2305Extracellular Potential
Transmembrane231 – 25121Helical; Potential
Topological domain252 – 27120Cytoplasmic Potential
Transmembrane272 – 29120Helical; Potential
Topological domain292 – 30918Extracellular Potential
Transmembrane310 – 33021Helical; Potential
Topological domain331 – 35020Cytoplasmic Potential
Transmembrane351 – 37121Helical; Potential
Topological domain372 – 38413Extracellular Potential
Transmembrane385 – 40521Helical; Potential
Topological domain406 – 43025Cytoplasmic Potential
Transmembrane431 – 45121Helical; Potential
Topological domain452 – 4532Extracellular Potential
Transmembrane454 – 47219Helical; Potential
Topological domain473 – 54977Cytoplasmic Potential
Transmembrane550 – 57021Helical; Potential
Topological domain571 – 5744Extracellular Potential

Sequences

Sequence LengthMass (Da)Tools
A4IIS8 [UniParc].

Last modified May 1, 2007. Version 1.
Checksum: CDC2BA5D2D406B15

FASTA57461,887
        10         20         30         40         50         60 
MEGQAAETNH RAETVVRAEL CLSAEQGPET TAYSQKRCLF LPMEVWQEAQ QLLALAAPAF 

        70         80         90        100        110        120 
LSQLMIFLIS IVSSIFCGHL GKVELDAVSL AITIINITGV AVGTGLAGAC DTLISQTFGG 

       130        140        150        160        170        180 
SNLKLVGIIL QRGILILLLF CFPCWALLIN TESILLLFRQ DPEVSKLTQI YVLIFLPALP 

       190        200        210        220        230        240 
AAFLYQLLAK YLQNQGIIYP QVLTGFIANI FNALFNYILL YVLGLGVMGS ACANTVSQFI 

       250        260        270        280        290        300 
QMILLFLYIV WRRLYADTWG GWSQACFEEW GAFIRLAVAS MLMLCIEWWA FEISMFLAGV 

       310        320        330        340        350        360 
LGMVDLAAQA IIYQVAIVVY LIPLGLCIAG SIRVGHGLGA GNTEQAKRSA LVVLCMTELC 

       370        380        390        400        410        420 
ALLSGILLAT LKDVVAYIFT SDPNIVALVS YVLPVYSACL LFDACVAACG GILRGSGKLK 

       430        440        450        460        470        480 
VGAISHTVGY YVIGLPLGIS LMFAAKLGII GFWFGILACG IAQSIFLIIF VFKIDWKRAS 

       490        500        510        520        530        540 
EEAQTRASER VEIPQKIDNK PSVYQEGCPT EQGDVDPGNV ESIEFSQSST SSEGTSPTPA 

       550        560        570 
GAAQHTRTLI LTRGLALGCA VGTLIIGIVI RLSV 

« Hide

References

[1]NIH - Xenopus Gene Collection (XGC) project
Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC136138 mRNA. Translation: AAI36139.1.
RefSeqNP_001096440.1. NM_001102970.1.
UniGeneStr.64530.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING8364.ENSXETP00000049598.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100125051.
KEGGxtr:100125051.

Organism-specific databases

CTD146802.
XenbaseXB-GENE-5793831. slc47a2.

Phylogenomic databases

eggNOGCOG0534.
HOGENOMHOG000060313.
HOVERGENHBG056043.
KOK03327.

Family and domain databases

InterProIPR002528. MATE.
[Graphical view]
PfamPF01554. MatE. 2 hits.
[Graphical view]
TIGRFAMsTIGR00797. matE. 1 hit.
ProtoNetSearch...

Entry information

Entry nameS47A1_XENTR
AccessionPrimary (citable) accession number: A4IIS8
Entry history
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: May 1, 2007
Last modified: March 19, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families