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Protein

Multidrug and toxin extrusion protein 1

Gene

slc47a1

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Solute transporter for tetraethylammonium (TEA), cimetidine, metformin, guanidine, N-methylnicotinamide (NMN) and also the zwitterionic cephalosporin cephalexin. Responsible for the secretion of cationic drugs across the brush border membranes (By similarity).By similarity

GO - Molecular functioni

  1. antiporter activity Source: InterPro
  2. drug transmembrane transporter activity Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Multidrug and toxin extrusion protein 1
Short name:
MATE-1
Alternative name(s):
Solute carrier family 47 member 1
Gene namesi
Name:slc47a1
Synonyms:mate1
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
ProteomesiUP000008143: Unplaced

Organism-specific databases

XenbaseiXB-GENE-5793831. slc47a2.

Subcellular locationi

Cell membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5151CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei52 – 7221HelicalSequence AnalysisAdd
BLAST
Topological domaini73 – 8614ExtracellularSequence AnalysisAdd
BLAST
Transmembranei87 – 10721HelicalSequence AnalysisAdd
BLAST
Topological domaini108 – 13326CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei134 – 15421HelicalSequence AnalysisAdd
BLAST
Topological domaini155 – 16814ExtracellularSequence AnalysisAdd
BLAST
Transmembranei169 – 18921HelicalSequence AnalysisAdd
BLAST
Topological domaini190 – 20415CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei205 – 22521HelicalSequence AnalysisAdd
BLAST
Topological domaini226 – 2305ExtracellularSequence Analysis
Transmembranei231 – 25121HelicalSequence AnalysisAdd
BLAST
Topological domaini252 – 27120CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei272 – 29120HelicalSequence AnalysisAdd
BLAST
Topological domaini292 – 30918ExtracellularSequence AnalysisAdd
BLAST
Transmembranei310 – 33021HelicalSequence AnalysisAdd
BLAST
Topological domaini331 – 35020CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei351 – 37121HelicalSequence AnalysisAdd
BLAST
Topological domaini372 – 38413ExtracellularSequence AnalysisAdd
BLAST
Transmembranei385 – 40521HelicalSequence AnalysisAdd
BLAST
Topological domaini406 – 43025CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei431 – 45121HelicalSequence AnalysisAdd
BLAST
Topological domaini452 – 4532ExtracellularSequence Analysis
Transmembranei454 – 47219HelicalSequence AnalysisAdd
BLAST
Topological domaini473 – 54977CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei550 – 57021HelicalSequence AnalysisAdd
BLAST
Topological domaini571 – 5744ExtracellularSequence Analysis

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 574574Multidrug and toxin extrusion protein 1PRO_0000312851Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000049598.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0534.
HOGENOMiHOG000060313.
HOVERGENiHBG056043.
InParanoidiA4IIS8.
KOiK03327.

Family and domain databases

InterProiIPR002528. MATE.
[Graphical view]
PfamiPF01554. MatE. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00797. matE. 1 hit.

Sequencei

Sequence statusi: Complete.

A4IIS8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEGQAAETNH RAETVVRAEL CLSAEQGPET TAYSQKRCLF LPMEVWQEAQ
60 70 80 90 100
QLLALAAPAF LSQLMIFLIS IVSSIFCGHL GKVELDAVSL AITIINITGV
110 120 130 140 150
AVGTGLAGAC DTLISQTFGG SNLKLVGIIL QRGILILLLF CFPCWALLIN
160 170 180 190 200
TESILLLFRQ DPEVSKLTQI YVLIFLPALP AAFLYQLLAK YLQNQGIIYP
210 220 230 240 250
QVLTGFIANI FNALFNYILL YVLGLGVMGS ACANTVSQFI QMILLFLYIV
260 270 280 290 300
WRRLYADTWG GWSQACFEEW GAFIRLAVAS MLMLCIEWWA FEISMFLAGV
310 320 330 340 350
LGMVDLAAQA IIYQVAIVVY LIPLGLCIAG SIRVGHGLGA GNTEQAKRSA
360 370 380 390 400
LVVLCMTELC ALLSGILLAT LKDVVAYIFT SDPNIVALVS YVLPVYSACL
410 420 430 440 450
LFDACVAACG GILRGSGKLK VGAISHTVGY YVIGLPLGIS LMFAAKLGII
460 470 480 490 500
GFWFGILACG IAQSIFLIIF VFKIDWKRAS EEAQTRASER VEIPQKIDNK
510 520 530 540 550
PSVYQEGCPT EQGDVDPGNV ESIEFSQSST SSEGTSPTPA GAAQHTRTLI
560 570
LTRGLALGCA VGTLIIGIVI RLSV
Length:574
Mass (Da):61,887
Last modified:May 1, 2007 - v1
Checksum:iCDC2BA5D2D406B15
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC136138 mRNA. Translation: AAI36139.1.
RefSeqiNP_001096440.1. NM_001102970.1.
UniGeneiStr.64530.

Genome annotation databases

GeneIDi100125051.
KEGGixtr:100125051.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC136138 mRNA. Translation: AAI36139.1.
RefSeqiNP_001096440.1. NM_001102970.1.
UniGeneiStr.64530.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi8364.ENSXETP00000049598.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100125051.
KEGGixtr:100125051.

Organism-specific databases

CTDi146802.
XenbaseiXB-GENE-5793831. slc47a2.

Phylogenomic databases

eggNOGiCOG0534.
HOGENOMiHOG000060313.
HOVERGENiHBG056043.
InParanoidiA4IIS8.
KOiK03327.

Family and domain databases

InterProiIPR002528. MATE.
[Graphical view]
PfamiPF01554. MatE. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00797. matE. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiS47A1_XENTR
AccessioniPrimary (citable) accession number: A4IIS8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: May 1, 2007
Last modified: January 7, 2015
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.