Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Multidrug and toxin extrusion protein 1

Gene

slc47a1

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Solute transporter for tetraethylammonium (TEA), cimetidine, metformin, guanidine, N-methylnicotinamide (NMN) and also the zwitterionic cephalosporin cephalexin. Responsible for the secretion of cationic drugs across the brush border membranes (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Multidrug and toxin extrusion protein 1
Short name:
MATE-1
Alternative name(s):
Solute carrier family 47 member 1
Gene namesi
Name:slc47a1
Synonyms:mate1
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-5793831. slc47a2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 51CytoplasmicSequence analysisAdd BLAST51
Transmembranei52 – 72HelicalSequence analysisAdd BLAST21
Topological domaini73 – 86ExtracellularSequence analysisAdd BLAST14
Transmembranei87 – 107HelicalSequence analysisAdd BLAST21
Topological domaini108 – 133CytoplasmicSequence analysisAdd BLAST26
Transmembranei134 – 154HelicalSequence analysisAdd BLAST21
Topological domaini155 – 168ExtracellularSequence analysisAdd BLAST14
Transmembranei169 – 189HelicalSequence analysisAdd BLAST21
Topological domaini190 – 204CytoplasmicSequence analysisAdd BLAST15
Transmembranei205 – 225HelicalSequence analysisAdd BLAST21
Topological domaini226 – 230ExtracellularSequence analysis5
Transmembranei231 – 251HelicalSequence analysisAdd BLAST21
Topological domaini252 – 271CytoplasmicSequence analysisAdd BLAST20
Transmembranei272 – 291HelicalSequence analysisAdd BLAST20
Topological domaini292 – 309ExtracellularSequence analysisAdd BLAST18
Transmembranei310 – 330HelicalSequence analysisAdd BLAST21
Topological domaini331 – 350CytoplasmicSequence analysisAdd BLAST20
Transmembranei351 – 371HelicalSequence analysisAdd BLAST21
Topological domaini372 – 384ExtracellularSequence analysisAdd BLAST13
Transmembranei385 – 405HelicalSequence analysisAdd BLAST21
Topological domaini406 – 430CytoplasmicSequence analysisAdd BLAST25
Transmembranei431 – 451HelicalSequence analysisAdd BLAST21
Topological domaini452 – 453ExtracellularSequence analysis2
Transmembranei454 – 472HelicalSequence analysisAdd BLAST19
Topological domaini473 – 549CytoplasmicSequence analysisAdd BLAST77
Transmembranei550 – 570HelicalSequence analysisAdd BLAST21
Topological domaini571 – 574ExtracellularSequence analysis4

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003128511 – 574Multidrug and toxin extrusion protein 1Add BLAST574

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000060313.
HOVERGENiHBG056043.
InParanoidiA4IIS8.
KOiK03327.

Family and domain databases

InterProiIPR002528. MATE_fam.
[Graphical view]
PfamiPF01554. MatE. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00797. matE. 1 hit.

Sequencei

Sequence statusi: Complete.

A4IIS8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGQAAETNH RAETVVRAEL CLSAEQGPET TAYSQKRCLF LPMEVWQEAQ
60 70 80 90 100
QLLALAAPAF LSQLMIFLIS IVSSIFCGHL GKVELDAVSL AITIINITGV
110 120 130 140 150
AVGTGLAGAC DTLISQTFGG SNLKLVGIIL QRGILILLLF CFPCWALLIN
160 170 180 190 200
TESILLLFRQ DPEVSKLTQI YVLIFLPALP AAFLYQLLAK YLQNQGIIYP
210 220 230 240 250
QVLTGFIANI FNALFNYILL YVLGLGVMGS ACANTVSQFI QMILLFLYIV
260 270 280 290 300
WRRLYADTWG GWSQACFEEW GAFIRLAVAS MLMLCIEWWA FEISMFLAGV
310 320 330 340 350
LGMVDLAAQA IIYQVAIVVY LIPLGLCIAG SIRVGHGLGA GNTEQAKRSA
360 370 380 390 400
LVVLCMTELC ALLSGILLAT LKDVVAYIFT SDPNIVALVS YVLPVYSACL
410 420 430 440 450
LFDACVAACG GILRGSGKLK VGAISHTVGY YVIGLPLGIS LMFAAKLGII
460 470 480 490 500
GFWFGILACG IAQSIFLIIF VFKIDWKRAS EEAQTRASER VEIPQKIDNK
510 520 530 540 550
PSVYQEGCPT EQGDVDPGNV ESIEFSQSST SSEGTSPTPA GAAQHTRTLI
560 570
LTRGLALGCA VGTLIIGIVI RLSV
Length:574
Mass (Da):61,887
Last modified:May 1, 2007 - v1
Checksum:iCDC2BA5D2D406B15
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC136138 mRNA. Translation: AAI36139.1.
RefSeqiNP_001096440.1. NM_001102970.1.
UniGeneiStr.64530.

Genome annotation databases

GeneIDi100125051.
KEGGixtr:100125051.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC136138 mRNA. Translation: AAI36139.1.
RefSeqiNP_001096440.1. NM_001102970.1.
UniGeneiStr.64530.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100125051.
KEGGixtr:100125051.

Organism-specific databases

CTDi146802.
XenbaseiXB-GENE-5793831. slc47a2.

Phylogenomic databases

HOGENOMiHOG000060313.
HOVERGENiHBG056043.
InParanoidiA4IIS8.
KOiK03327.

Family and domain databases

InterProiIPR002528. MATE_fam.
[Graphical view]
PfamiPF01554. MatE. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00797. matE. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiS47A1_XENTR
AccessioniPrimary (citable) accession number: A4IIS8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: May 1, 2007
Last modified: February 17, 2016
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.