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Protein

mRNA decay activator protein ZFP36L2

Gene

zfp36l2

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (By similarity). Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (By similarity). Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes (By similarity). Binds to 3'-UTR ARE of numerous mRNAs (By similarity). Induces also the degradation of ARE-containing mRNAs even in absence of poly(A) tail (By similarity). Required for tubulogenesis during pronephros development (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri130 – 158C3H1-type 1PROSITE-ProRule annotationAdd BLAST29
Zinc fingeri168 – 196C3H1-type 2PROSITE-ProRule annotationAdd BLAST29

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Ribonucleoprotein

Keywords - Ligandi

DNA-binding, Metal-binding, RNA-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
mRNA decay activator protein ZFP36L2Curated
Alternative name(s):
Zinc finger protein 36, C3H1 type-like 2
Gene namesi
Name:zfp36l2
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-971012. zfp36l2.

Subcellular locationi

  • Nucleus By similarity
  • Cytoplasm By similarity

  • Note: Shuttles between the nucleus and the cytoplasm in a XPO1/CRM1-dependent manner.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003979151 – 362mRNA decay activator protein ZFP36L2Add BLAST362

Post-translational modificationi

Phosphorylated (By similarity).By similarity

Proteomic databases

PaxDbiA4IIN5.

Expressioni

Gene expression databases

BgeeiENSXETG00000009274.

Interactioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000020367.

Structurei

3D structure databases

ProteinModelPortaliA4IIN5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni147 – 188RNA-bindingBy similarityAdd BLAST42

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi130 – 135RNA-bindingBy similarity6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi109 – 125Gln-richAdd BLAST17
Compositional biasi292 – 360Ser-richAdd BLAST69

Sequence similaritiesi

Contains 2 C3H1-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri130 – 158C3H1-type 1PROSITE-ProRule annotationAdd BLAST29
Zinc fingeri168 – 196C3H1-type 2PROSITE-ProRule annotationAdd BLAST29

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1677. Eukaryota.
COG5063. LUCA.
GeneTreeiENSGT00530000063262.
HOGENOMiHOG000233479.
HOVERGENiHBG008483.
InParanoidiA4IIN5.
KOiK18753.
OMAiQRDRPKL.
OrthoDBiEOG091G0957.
TreeFamiTF315463.

Family and domain databases

Gene3Di4.10.1000.10. 2 hits.
InterProiIPR007635. Tis11B_N.
IPR000571. Znf_CCCH.
[Graphical view]
PfamiPF04553. Tis11B_N. 1 hit.
PF00642. zf-CCCH. 2 hits.
[Graphical view]
SMARTiSM00356. ZnF_C3H1. 2 hits.
[Graphical view]
SUPFAMiSSF90229. SSF90229. 2 hits.
PROSITEiPS50103. ZF_C3H1. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4IIN5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTTLLSAFY DIDLLYKNEK VLNNLALSTM LDKKAVGSPV SSTNSNLFPG
60 70 80 90 100
FLRRHSASNL QALSGNTNPA KFCPNNNQLK EPAAGSTALL NRENKFRDRS
110 120 130 140 150
FSENGERSQH LLHLQQQQQQ KAGAQVNSTR YKTELCRPFE ESGACKYGEK
160 170 180 190 200
CQFAHGFHEL RSLTRHPKYK TELCRTFHTI GFCPYGPRCH FIHNAEERRQ
210 220 230 240 250
APGAGERPKL HHSLSFSGFP NHSLDSPLLE SPTSRTPPPQ SSSSLYCQEL
260 270 280 290 300
LQLNNNNNPC ANNAFTFSGQ ELGLIAPLAI HTQNPPYCRQ PSSSPPLSFQ
310 320 330 340 350
PLRRVSESPV FDAPPSPPDS LSDRDSYLSG SLSSGSLSGS DSPTLDSNRR
360
LPIFSRLSIS DD
Length:362
Mass (Da):40,065
Last modified:September 18, 2013 - v2
Checksum:i94DC5A963C219E00
GO

Sequence cautioni

The sequence AAI36092 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti191F → L in AAI36092 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAMC01011930 Genomic DNA. No translation available.
BC136091 mRNA. Translation: AAI36092.1. Different initiation.
RefSeqiNP_001096423.1. NM_001102953.1.
XP_012818082.1. XM_012962628.2.
UniGeneiStr.6563.

Genome annotation databases

EnsembliENSXETT00000020367; ENSXETP00000020367; ENSXETG00000009274.
GeneIDi100125029.
KEGGixtr:100125029.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAMC01011930 Genomic DNA. No translation available.
BC136091 mRNA. Translation: AAI36092.1. Different initiation.
RefSeqiNP_001096423.1. NM_001102953.1.
XP_012818082.1. XM_012962628.2.
UniGeneiStr.6563.

3D structure databases

ProteinModelPortaliA4IIN5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi8364.ENSXETP00000020367.

Proteomic databases

PaxDbiA4IIN5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSXETT00000020367; ENSXETP00000020367; ENSXETG00000009274.
GeneIDi100125029.
KEGGixtr:100125029.

Organism-specific databases

CTDi678.
XenbaseiXB-GENE-971012. zfp36l2.

Phylogenomic databases

eggNOGiKOG1677. Eukaryota.
COG5063. LUCA.
GeneTreeiENSGT00530000063262.
HOGENOMiHOG000233479.
HOVERGENiHBG008483.
InParanoidiA4IIN5.
KOiK18753.
OMAiQRDRPKL.
OrthoDBiEOG091G0957.
TreeFamiTF315463.

Gene expression databases

BgeeiENSXETG00000009274.

Family and domain databases

Gene3Di4.10.1000.10. 2 hits.
InterProiIPR007635. Tis11B_N.
IPR000571. Znf_CCCH.
[Graphical view]
PfamiPF04553. Tis11B_N. 1 hit.
PF00642. zf-CCCH. 2 hits.
[Graphical view]
SMARTiSM00356. ZnF_C3H1. 2 hits.
[Graphical view]
SUPFAMiSSF90229. SSF90229. 2 hits.
PROSITEiPS50103. ZF_C3H1. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTISD_XENTR
AccessioniPrimary (citable) accession number: A4IIN5
Secondary accession number(s): F7CNB8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: September 18, 2013
Last modified: November 30, 2016
This is version 52 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.