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Protein

mRNA decay activator protein ZFP36L2

Gene

zfp36l2

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (By similarity). Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (By similarity). Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes (By similarity). Binds to 3'-UTR ARE of numerous mRNAs (By similarity). Induces also the degradation of ARE-containing mRNAs even in absence of poly(A) tail (By similarity). Required for tubulogenesis during pronephros development (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri130 – 158C3H1-type 1PROSITE-ProRule annotationAdd BLAST29
Zinc fingeri168 – 196C3H1-type 2PROSITE-ProRule annotationAdd BLAST29

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding, Ribonucleoprotein, RNA-binding
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
mRNA decay activator protein ZFP36L2Curated
Alternative name(s):
Zinc finger protein 36, C3H1 type-like 2
Gene namesi
Name:zfp36l2
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-971012 zfp36l2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003979151 – 362mRNA decay activator protein ZFP36L2Add BLAST362

Post-translational modificationi

Phosphorylated (By similarity).By similarity

Proteomic databases

PaxDbiA4IIN5

Expressioni

Gene expression databases

BgeeiENSXETG00000009274

Interactioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000020367

Structurei

3D structure databases

ProteinModelPortaliA4IIN5
SMRiA4IIN5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni147 – 188RNA-bindingBy similarityAdd BLAST42

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi130 – 135RNA-bindingBy similarity6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi109 – 125Gln-richAdd BLAST17
Compositional biasi292 – 360Ser-richAdd BLAST69

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri130 – 158C3H1-type 1PROSITE-ProRule annotationAdd BLAST29
Zinc fingeri168 – 196C3H1-type 2PROSITE-ProRule annotationAdd BLAST29

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1677 Eukaryota
COG5063 LUCA
GeneTreeiENSGT00530000063262
HOGENOMiHOG000233479
HOVERGENiHBG008483
InParanoidiA4IIN5
KOiK18753
OMAiQRDRPKL
OrthoDBiEOG091G0957
TreeFamiTF315463

Family and domain databases

InterProiView protein in InterPro
IPR007635 Tis11B_N
IPR000571 Znf_CCCH
IPR036855 Znf_CCCH_sf
PfamiView protein in Pfam
PF04553 Tis11B_N, 1 hit
PF00642 zf-CCCH, 2 hits
SMARTiView protein in SMART
SM00356 ZnF_C3H1, 2 hits
SUPFAMiSSF90229 SSF90229, 2 hits
PROSITEiView protein in PROSITE
PS50103 ZF_C3H1, 2 hits

Sequencei

Sequence statusi: Complete.

A4IIN5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTTLLSAFY DIDLLYKNEK VLNNLALSTM LDKKAVGSPV SSTNSNLFPG
60 70 80 90 100
FLRRHSASNL QALSGNTNPA KFCPNNNQLK EPAAGSTALL NRENKFRDRS
110 120 130 140 150
FSENGERSQH LLHLQQQQQQ KAGAQVNSTR YKTELCRPFE ESGACKYGEK
160 170 180 190 200
CQFAHGFHEL RSLTRHPKYK TELCRTFHTI GFCPYGPRCH FIHNAEERRQ
210 220 230 240 250
APGAGERPKL HHSLSFSGFP NHSLDSPLLE SPTSRTPPPQ SSSSLYCQEL
260 270 280 290 300
LQLNNNNNPC ANNAFTFSGQ ELGLIAPLAI HTQNPPYCRQ PSSSPPLSFQ
310 320 330 340 350
PLRRVSESPV FDAPPSPPDS LSDRDSYLSG SLSSGSLSGS DSPTLDSNRR
360
LPIFSRLSIS DD
Length:362
Mass (Da):40,065
Last modified:September 18, 2013 - v2
Checksum:i94DC5A963C219E00
GO

Sequence cautioni

The sequence AAI36092 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti191F → L in AAI36092 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAMC01011930 Genomic DNA No translation available.
BC136091 mRNA Translation: AAI36092.1 Different initiation.
RefSeqiNP_001096423.1, NM_001102953.1
XP_012818082.1, XM_012962628.2
UniGeneiStr.6563

Genome annotation databases

EnsembliENSXETT00000020367; ENSXETP00000020367; ENSXETG00000009274
GeneIDi100125029
KEGGixtr:100125029

Similar proteinsi

Entry informationi

Entry nameiTISD_XENTR
AccessioniPrimary (citable) accession number: A4IIN5
Secondary accession number(s): F7CNB8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: September 18, 2013
Last modified: April 25, 2018
This is version 59 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health