ID   NR4A2_XENTR             Reviewed;         591 AA.
AC   A4IIG7;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 1.
DT   27-MAR-2024, entry version 106.
DE   RecName: Full=Nuclear receptor subfamily 4 group A member 2;
GN   Name=nr4a2;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcriptional regulator which may play a role in the
CC       differentiation and maintenance of meso-diencephalic dopaminergic
CC       (mdDA) neurons. {ECO:0000250|UniProtKB:Q06219}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P43354}. Nucleus
CC       {ECO:0000250|UniProtKB:P43354}.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
CC       {ECO:0000305}.
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DR   EMBL; BC136009; AAI36010.1; -; mRNA.
DR   RefSeq; NP_001093678.1; NM_001100208.1.
DR   AlphaFoldDB; A4IIG7; -.
DR   SMR; A4IIG7; -.
DR   STRING; 8364.ENSXETP00000010149; -.
DR   PaxDb; 8364-ENSXETP00000011580; -.
DR   DNASU; 100101682; -.
DR   Ensembl; ENSXETT00000011580; ENSXETP00000011580; ENSXETG00000031753.
DR   GeneID; 100101682; -.
DR   KEGG; xtr:100101682; -.
DR   AGR; Xenbase:XB-GENE-480893; -.
DR   CTD; 4929; -.
DR   Xenbase; XB-GENE-480893; nr4a2.
DR   eggNOG; KOG4217; Eukaryota.
DR   HOGENOM; CLU_007368_14_2_1; -.
DR   InParanoid; A4IIG7; -.
DR   OMA; GSCQMRF; -.
DR   OrthoDB; 5395768at2759; -.
DR   PhylomeDB; A4IIG7; -.
DR   TreeFam; TF315430; -.
DR   Proteomes; UP000008143; Chromosome 9.
DR   Bgee; ENSXETG00000031753; Expressed in brain and 10 other cell types or tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0004879; F:nuclear receptor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd06969; NR_DBD_NGFI-B; 1.
DR   Gene3D; 3.30.50.10; Erythroid Transcription Factor GATA-1, subunit A; 1.
DR   Gene3D; 1.10.565.10; Retinoid X Receptor; 1.
DR   InterPro; IPR035500; NHR-like_dom_sf.
DR   InterPro; IPR003070; NR4A1-3.
DR   InterPro; IPR003073; NR4A2.
DR   InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR   InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR   InterPro; IPR001628; Znf_hrmn_rcpt.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   PANTHER; PTHR24085; NUCLEAR HORMONE RECEPTOR; 1.
DR   PANTHER; PTHR24085:SF0; NUCLEAR RECEPTOR SUBFAMILY 4 GROUP A MEMBER 2; 1.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   PRINTS; PR01284; NUCLEARECPTR.
DR   PRINTS; PR01287; NURRNUCRCPTR.
DR   PRINTS; PR00398; STRDHORMONER.
DR   PRINTS; PR00047; STROIDFINGER.
DR   SMART; SM00430; HOLI; 1.
DR   SMART; SM00399; ZnF_C4; 1.
DR   SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR   SUPFAM; SSF48508; Nuclear receptor ligand-binding domain; 1.
DR   PROSITE; PS51843; NR_LBD; 1.
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; DNA-binding; Metal-binding; Nucleus; Receptor;
KW   Reference proteome; Transcription; Transcription regulation; Zinc;
KW   Zinc-finger.
FT   CHAIN           1..591
FT                   /note="Nuclear receptor subfamily 4 group A member 2"
FT                   /id="PRO_0000326153"
FT   DOMAIN          353..588
FT                   /note="NR LBD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT   DNA_BIND        253..328
FT                   /note="Nuclear receptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         256..276
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         292..311
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          110..133
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          330..354
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           280..307
FT                   /note="Bipartite nuclear localization signal (NLS1)"
FT                   /evidence="ECO:0000250"
FT   MOTIF           331..343
FT                   /note="Nuclear localization signal (NLS1)"
FT                   /evidence="ECO:0000250"
FT   MOTIF           436..445
FT                   /note="nuclear export sequence (NES1)"
FT                   /evidence="ECO:0000250"
FT   MOTIF           561..570
FT                   /note="nuclear export sequence (NES2)"
FT                   /evidence="ECO:0000250"
FT   COMPBIAS        112..133
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   591 AA;  65681 MW;  E3DD191ED465C45C CRC64;
     MPCVQAQYGS SPQGASPASQ SYTYHSSGEY SSDFLTPEFV KFSMDLTNTE ITATTSLPSF
     STFMDNYNTS YDVKPPCLYQ MPLSGQQSSV KVEDIQMHGY QQHGHLPPQS EEMMSHSGSV
     YYKPSSPPTS STPGFPVQHS PMWDNHGSLH SFNQNYVATR GGHVPRLSLF SFKQSPPGTP
     VSSCQMRFDG HHVSMNPETS GAHHVIDGQT FAVPNPIRKQ ASMGFPGLQL GHASQLIDSQ
     VPSPPSRGSP SNEGLCAVCG DNAACQHYGV RTCEGCKGFF KRTVQKNAKY VCLANKNCPV
     DKRRRNRCQY CRFQKCLVVG MVKEVVRTDS LKGRRGRLPS KPKSPQEPSP PSPPVSLISA
     LVRAHVDSNP AVSSLDYSRF QANPEYQMNG DDTQHIQQFY DLLTGSMEII RGWAEKIPGF
     SELHKQDQDL LFESAFLELF VLRLAYRSNP AEGKLIFCNG VVLNRLQCVR GFGEWIDSIV
     DFSSNLHSMN IDISAFSCIA ALAVITERHG LKEPKRVEEL QNKIVNCLKD HVTFNNGGLN
     RPNYLSKLLG KLPELRTLCT QGLQRIFYLK LEDLVPPPAI IDKLFLDTLP F
//