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Protein

Nuclear receptor subfamily 4 group A member 2

Gene

nr4a2

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Transcriptional regulator which may play a role in the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi253 – 32876Nuclear receptorPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri256 – 27621NR C4-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri292 – 31120NR C4-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_287606. Nuclear Receptor transcription pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear receptor subfamily 4 group A member 2
Gene namesi
Name:nr4a2
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
ProteomesiUP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-480893. nr4a2.

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 591591Nuclear receptor subfamily 4 group A member 2PRO_0000326153Add
BLAST

Expressioni

Gene expression databases

BgeeiA4IIG7.

Interactioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000011580.

Structurei

3D structure databases

ProteinModelPortaliA4IIG7.
SMRiA4IIG7. Positions 254-591.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni402 – 45251Ligand-bindingSequence AnalysisAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi280 – 30728Bipartite nuclear localization signal (NLS1)By similarityAdd
BLAST
Motifi331 – 34313Nuclear localization signal (NLS1)By similarityAdd
BLAST
Motifi436 – 44510nuclear export sequence (NES1)By similarity
Motifi561 – 57010nuclear export sequence (NES2)By similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi80 – 13859Gln-richAdd
BLAST
Compositional biasi127 – 226100Pro-richAdd
BLAST
Compositional biasi339 – 38446Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the nuclear hormone receptor family.Curated
Contains 1 nuclear receptor DNA-binding domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri256 – 27621NR C4-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri292 – 31120NR C4-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

GeneTreeiENSGT00760000118887.
HOVERGENiHBG052663.
InParanoidiA4IIG7.
KOiK08558.
OMAiEYSCDFL.
OrthoDBiEOG75XGKJ.
TreeFamiTF315430.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR003070. Nuc_orph_rcpt.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR003073. NURR_rcpt.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR01284. NUCLEARECPTR.
PR01287. NURRNUCRCPTR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4IIG7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPCVQAQYGS SPQGASPASQ SYTYHSSGEY SSDFLTPEFV KFSMDLTNTE
60 70 80 90 100
ITATTSLPSF STFMDNYNTS YDVKPPCLYQ MPLSGQQSSV KVEDIQMHGY
110 120 130 140 150
QQHGHLPPQS EEMMSHSGSV YYKPSSPPTS STPGFPVQHS PMWDNHGSLH
160 170 180 190 200
SFNQNYVATR GGHVPRLSLF SFKQSPPGTP VSSCQMRFDG HHVSMNPETS
210 220 230 240 250
GAHHVIDGQT FAVPNPIRKQ ASMGFPGLQL GHASQLIDSQ VPSPPSRGSP
260 270 280 290 300
SNEGLCAVCG DNAACQHYGV RTCEGCKGFF KRTVQKNAKY VCLANKNCPV
310 320 330 340 350
DKRRRNRCQY CRFQKCLVVG MVKEVVRTDS LKGRRGRLPS KPKSPQEPSP
360 370 380 390 400
PSPPVSLISA LVRAHVDSNP AVSSLDYSRF QANPEYQMNG DDTQHIQQFY
410 420 430 440 450
DLLTGSMEII RGWAEKIPGF SELHKQDQDL LFESAFLELF VLRLAYRSNP
460 470 480 490 500
AEGKLIFCNG VVLNRLQCVR GFGEWIDSIV DFSSNLHSMN IDISAFSCIA
510 520 530 540 550
ALAVITERHG LKEPKRVEEL QNKIVNCLKD HVTFNNGGLN RPNYLSKLLG
560 570 580 590
KLPELRTLCT QGLQRIFYLK LEDLVPPPAI IDKLFLDTLP F
Length:591
Mass (Da):65,681
Last modified:May 1, 2007 - v1
Checksum:iE3DD191ED465C45C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC136009 mRNA. Translation: AAI36010.1.
RefSeqiNP_001093678.1. NM_001100208.1.
UniGeneiStr.34862.

Genome annotation databases

EnsembliENSXETT00000011580; ENSXETP00000011580; ENSXETG00000031753.
GeneIDi100101682.
KEGGixtr:100101682.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC136009 mRNA. Translation: AAI36010.1.
RefSeqiNP_001093678.1. NM_001100208.1.
UniGeneiStr.34862.

3D structure databases

ProteinModelPortaliA4IIG7.
SMRiA4IIG7. Positions 254-591.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi8364.ENSXETP00000011580.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSXETT00000011580; ENSXETP00000011580; ENSXETG00000031753.
GeneIDi100101682.
KEGGixtr:100101682.

Organism-specific databases

CTDi4929.
XenbaseiXB-GENE-480893. nr4a2.

Phylogenomic databases

GeneTreeiENSGT00760000118887.
HOVERGENiHBG052663.
InParanoidiA4IIG7.
KOiK08558.
OMAiEYSCDFL.
OrthoDBiEOG75XGKJ.
TreeFamiTF315430.

Enzyme and pathway databases

ReactomeiREACT_287606. Nuclear Receptor transcription pathway.

Gene expression databases

BgeeiA4IIG7.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR003070. Nuc_orph_rcpt.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR003073. NURR_rcpt.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR01284. NUCLEARECPTR.
PR01287. NURRNUCRCPTR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiNR4A2_XENTR
AccessioniPrimary (citable) accession number: A4IIG7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: May 1, 2007
Last modified: July 22, 2015
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.