Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

A4IIG7 (NR4A2_XENTR) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Nuclear receptor subfamily 4 group A member 2
Gene names
Name:nr4a2
OrganismXenopus tropicalis (Western clawed frog) (Silurana tropicalis) [Reference proteome]
Taxonomic identifier8364 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana

Protein attributes

Sequence length591 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Transcriptional regulator which may play a role in the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons By similarity.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity.

Sequence similarities

Belongs to the nuclear hormone receptor family.

Contains 1 nuclear receptor DNA-binding domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 591591Nuclear receptor subfamily 4 group A member 2
PRO_0000326153

Regions

DNA binding253 – 32876Nuclear receptor
Zinc finger256 – 27621NR C4-type
Zinc finger292 – 31120NR C4-type
Region402 – 45251Ligand-binding Potential
Motif280 – 30728Bipartite nuclear localization signal (NLS1) By similarity
Motif331 – 34313Nuclear localization signal (NLS1) By similarity
Motif436 – 44510nuclear export sequence (NES1) By similarity
Motif561 – 57010nuclear export sequence (NES2) By similarity
Compositional bias80 – 13859Gln-rich
Compositional bias127 – 226100Pro-rich
Compositional bias339 – 38446Pro-rich

Sequences

Sequence LengthMass (Da)Tools
A4IIG7 [UniParc].

Last modified May 1, 2007. Version 1.
Checksum: E3DD191ED465C45C

FASTA59165,681
        10         20         30         40         50         60 
MPCVQAQYGS SPQGASPASQ SYTYHSSGEY SSDFLTPEFV KFSMDLTNTE ITATTSLPSF 

        70         80         90        100        110        120 
STFMDNYNTS YDVKPPCLYQ MPLSGQQSSV KVEDIQMHGY QQHGHLPPQS EEMMSHSGSV 

       130        140        150        160        170        180 
YYKPSSPPTS STPGFPVQHS PMWDNHGSLH SFNQNYVATR GGHVPRLSLF SFKQSPPGTP 

       190        200        210        220        230        240 
VSSCQMRFDG HHVSMNPETS GAHHVIDGQT FAVPNPIRKQ ASMGFPGLQL GHASQLIDSQ 

       250        260        270        280        290        300 
VPSPPSRGSP SNEGLCAVCG DNAACQHYGV RTCEGCKGFF KRTVQKNAKY VCLANKNCPV 

       310        320        330        340        350        360 
DKRRRNRCQY CRFQKCLVVG MVKEVVRTDS LKGRRGRLPS KPKSPQEPSP PSPPVSLISA 

       370        380        390        400        410        420 
LVRAHVDSNP AVSSLDYSRF QANPEYQMNG DDTQHIQQFY DLLTGSMEII RGWAEKIPGF 

       430        440        450        460        470        480 
SELHKQDQDL LFESAFLELF VLRLAYRSNP AEGKLIFCNG VVLNRLQCVR GFGEWIDSIV 

       490        500        510        520        530        540 
DFSSNLHSMN IDISAFSCIA ALAVITERHG LKEPKRVEEL QNKIVNCLKD HVTFNNGGLN 

       550        560        570        580        590 
RPNYLSKLLG KLPELRTLCT QGLQRIFYLK LEDLVPPPAI IDKLFLDTLP F 

« Hide

References

[1]NIH - Xenopus Gene Collection (XGC) project
Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC136009 mRNA. Translation: AAI36010.1.
RefSeqNP_001093678.1. NM_001100208.1.
UniGeneStr.34862.

3D structure databases

ProteinModelPortalA4IIG7.
SMRA4IIG7. Positions 254-591.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSXETT00000011580; ENSXETP00000011580; ENSXETG00000031753.
GeneID100101682.
KEGGxtr:100101682.

Organism-specific databases

CTD4929.
XenbaseXB-GENE-480893. nr4a2.

Phylogenomic databases

GeneTreeENSGT00740000115375.
HOVERGENHBG052663.
KOK08558.
OMAMWEDPGS.
OrthoDBEOG75XGKJ.
TreeFamTF315430.

Gene expression databases

BgeeA4IIG7.

Family and domain databases

Gene3D1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProIPR003070. Nuc_orph_rcpt.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR003073. NURR_rcpt.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSPR01284. NUCLEARECPTR.
PR01287. NURRNUCRCPTR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMSSF48508. SSF48508. 1 hit.
PROSITEPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNR4A2_XENTR
AccessionPrimary (citable) accession number: A4IIG7
Entry history
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: May 1, 2007
Last modified: April 16, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families