SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

A4IIG7

- NR4A2_XENTR

UniProt

A4IIG7 - NR4A2_XENTR

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Nuclear receptor subfamily 4 group A member 2

Gene
nr4a2
Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Transcriptional regulator which may play a role in the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi253 – 32876Nuclear receptorAdd
BLAST
Zinc fingeri256 – 27621NR C4-typeAdd
BLAST
Zinc fingeri292 – 31120NR C4-typeAdd
BLAST

GO - Molecular functioni

  1. ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity Source: InterPro
  2. sequence-specific DNA binding Source: InterPro
  3. steroid hormone receptor activity Source: InterPro
  4. zinc ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_210122. Nuclear Receptor transcription pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear receptor subfamily 4 group A member 2
Gene namesi
Name:nr4a2
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
ProteomesiUP000008143: Unplaced

Organism-specific databases

XenbaseiXB-GENE-480893. nr4a2.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 591591Nuclear receptor subfamily 4 group A member 2PRO_0000326153Add
BLAST

Expressioni

Gene expression databases

BgeeiA4IIG7.

Structurei

3D structure databases

ProteinModelPortaliA4IIG7.
SMRiA4IIG7. Positions 254-591.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni402 – 45251Ligand-binding Reviewed predictionAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi280 – 30728Bipartite nuclear localization signal (NLS1) By similarityAdd
BLAST
Motifi331 – 34313Nuclear localization signal (NLS1) By similarityAdd
BLAST
Motifi436 – 44510nuclear export sequence (NES1) By similarity
Motifi561 – 57010nuclear export sequence (NES2) By similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi80 – 13859Gln-richAdd
BLAST
Compositional biasi127 – 226100Pro-richAdd
BLAST
Compositional biasi339 – 38446Pro-richAdd
BLAST

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri256 – 27621NR C4-typeAdd
BLAST
Zinc fingeri292 – 31120NR C4-typeAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

GeneTreeiENSGT00740000115375.
HOVERGENiHBG052663.
KOiK08558.
OMAiMWEDPGS.
OrthoDBiEOG75XGKJ.
TreeFamiTF315430.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR003070. Nuc_orph_rcpt.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR003073. NURR_rcpt.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR01284. NUCLEARECPTR.
PR01287. NURRNUCRCPTR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A4IIG7-1 [UniParc]FASTAAdd to Basket

« Hide

MPCVQAQYGS SPQGASPASQ SYTYHSSGEY SSDFLTPEFV KFSMDLTNTE    50
ITATTSLPSF STFMDNYNTS YDVKPPCLYQ MPLSGQQSSV KVEDIQMHGY 100
QQHGHLPPQS EEMMSHSGSV YYKPSSPPTS STPGFPVQHS PMWDNHGSLH 150
SFNQNYVATR GGHVPRLSLF SFKQSPPGTP VSSCQMRFDG HHVSMNPETS 200
GAHHVIDGQT FAVPNPIRKQ ASMGFPGLQL GHASQLIDSQ VPSPPSRGSP 250
SNEGLCAVCG DNAACQHYGV RTCEGCKGFF KRTVQKNAKY VCLANKNCPV 300
DKRRRNRCQY CRFQKCLVVG MVKEVVRTDS LKGRRGRLPS KPKSPQEPSP 350
PSPPVSLISA LVRAHVDSNP AVSSLDYSRF QANPEYQMNG DDTQHIQQFY 400
DLLTGSMEII RGWAEKIPGF SELHKQDQDL LFESAFLELF VLRLAYRSNP 450
AEGKLIFCNG VVLNRLQCVR GFGEWIDSIV DFSSNLHSMN IDISAFSCIA 500
ALAVITERHG LKEPKRVEEL QNKIVNCLKD HVTFNNGGLN RPNYLSKLLG 550
KLPELRTLCT QGLQRIFYLK LEDLVPPPAI IDKLFLDTLP F 591
Length:591
Mass (Da):65,681
Last modified:May 1, 2007 - v1
Checksum:iE3DD191ED465C45C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC136009 mRNA. Translation: AAI36010.1.
RefSeqiNP_001093678.1. NM_001100208.1.
UniGeneiStr.34862.

Genome annotation databases

EnsembliENSXETT00000011580; ENSXETP00000011580; ENSXETG00000031753.
GeneIDi100101682.
KEGGixtr:100101682.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC136009 mRNA. Translation: AAI36010.1 .
RefSeqi NP_001093678.1. NM_001100208.1.
UniGenei Str.34862.

3D structure databases

ProteinModelPortali A4IIG7.
SMRi A4IIG7. Positions 254-591.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSXETT00000011580 ; ENSXETP00000011580 ; ENSXETG00000031753 .
GeneIDi 100101682.
KEGGi xtr:100101682.

Organism-specific databases

CTDi 4929.
Xenbasei XB-GENE-480893. nr4a2.

Phylogenomic databases

GeneTreei ENSGT00740000115375.
HOVERGENi HBG052663.
KOi K08558.
OMAi MWEDPGS.
OrthoDBi EOG75XGKJ.
TreeFami TF315430.

Enzyme and pathway databases

Reactomei REACT_210122. Nuclear Receptor transcription pathway.

Gene expression databases

Bgeei A4IIG7.

Family and domain databases

Gene3Di 1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProi IPR003070. Nuc_orph_rcpt.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR003073. NURR_rcpt.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view ]
Pfami PF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view ]
PRINTSi PR01284. NUCLEARECPTR.
PR01287. NURRNUCRCPTR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTi SM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view ]
SUPFAMi SSF48508. SSF48508. 1 hit.
PROSITEi PS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiNR4A2_XENTR
AccessioniPrimary (citable) accession number: A4IIG7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: May 1, 2007
Last modified: September 3, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi