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A4IIG7

- NR4A2_XENTR

UniProt

A4IIG7 - NR4A2_XENTR

Protein

Nuclear receptor subfamily 4 group A member 2

Gene

nr4a2

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 1 (01 May 2007)
      Previous versions | rss
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    Functioni

    Transcriptional regulator which may play a role in the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi253 – 32876Nuclear receptorPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri256 – 27621NR C4-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri292 – 31120NR C4-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity Source: InterPro
    2. sequence-specific DNA binding Source: InterPro
    3. steroid hormone receptor activity Source: InterPro
    4. zinc ion binding Source: InterPro

    Keywords - Molecular functioni

    Receptor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_210122. Nuclear Receptor transcription pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nuclear receptor subfamily 4 group A member 2
    Gene namesi
    Name:nr4a2
    OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
    Taxonomic identifieri8364 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
    ProteomesiUP000008143: Unplaced

    Organism-specific databases

    XenbaseiXB-GENE-480893. nr4a2.

    Subcellular locationi

    Cytoplasm By similarity. Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 591591Nuclear receptor subfamily 4 group A member 2PRO_0000326153Add
    BLAST

    Expressioni

    Gene expression databases

    BgeeiA4IIG7.

    Structurei

    3D structure databases

    ProteinModelPortaliA4IIG7.
    SMRiA4IIG7. Positions 254-591.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni402 – 45251Ligand-bindingSequence AnalysisAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi280 – 30728Bipartite nuclear localization signal (NLS1)By similarityAdd
    BLAST
    Motifi331 – 34313Nuclear localization signal (NLS1)By similarityAdd
    BLAST
    Motifi436 – 44510nuclear export sequence (NES1)By similarity
    Motifi561 – 57010nuclear export sequence (NES2)By similarity

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi80 – 13859Gln-richAdd
    BLAST
    Compositional biasi127 – 226100Pro-richAdd
    BLAST
    Compositional biasi339 – 38446Pro-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the nuclear hormone receptor family.Curated
    Contains 1 nuclear receptor DNA-binding domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri256 – 27621NR C4-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri292 – 31120NR C4-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    GeneTreeiENSGT00740000115375.
    HOVERGENiHBG052663.
    KOiK08558.
    OMAiMWEDPGS.
    OrthoDBiEOG75XGKJ.
    TreeFamiTF315430.

    Family and domain databases

    Gene3Di1.10.565.10. 1 hit.
    3.30.50.10. 1 hit.
    InterProiIPR003070. Nuc_orph_rcpt.
    IPR008946. Nucl_hormone_rcpt_ligand-bd.
    IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
    IPR003073. NURR_rcpt.
    IPR001723. Str_hrmn_rcpt.
    IPR001628. Znf_hrmn_rcpt.
    IPR013088. Znf_NHR/GATA.
    [Graphical view]
    PfamiPF00104. Hormone_recep. 1 hit.
    PF00105. zf-C4. 1 hit.
    [Graphical view]
    PRINTSiPR01284. NUCLEARECPTR.
    PR01287. NURRNUCRCPTR.
    PR00398. STRDHORMONER.
    PR00047. STROIDFINGER.
    SMARTiSM00430. HOLI. 1 hit.
    SM00399. ZnF_C4. 1 hit.
    [Graphical view]
    SUPFAMiSSF48508. SSF48508. 1 hit.
    PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
    PS51030. NUCLEAR_REC_DBD_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A4IIG7-1 [UniParc]FASTAAdd to Basket

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    MPCVQAQYGS SPQGASPASQ SYTYHSSGEY SSDFLTPEFV KFSMDLTNTE    50
    ITATTSLPSF STFMDNYNTS YDVKPPCLYQ MPLSGQQSSV KVEDIQMHGY 100
    QQHGHLPPQS EEMMSHSGSV YYKPSSPPTS STPGFPVQHS PMWDNHGSLH 150
    SFNQNYVATR GGHVPRLSLF SFKQSPPGTP VSSCQMRFDG HHVSMNPETS 200
    GAHHVIDGQT FAVPNPIRKQ ASMGFPGLQL GHASQLIDSQ VPSPPSRGSP 250
    SNEGLCAVCG DNAACQHYGV RTCEGCKGFF KRTVQKNAKY VCLANKNCPV 300
    DKRRRNRCQY CRFQKCLVVG MVKEVVRTDS LKGRRGRLPS KPKSPQEPSP 350
    PSPPVSLISA LVRAHVDSNP AVSSLDYSRF QANPEYQMNG DDTQHIQQFY 400
    DLLTGSMEII RGWAEKIPGF SELHKQDQDL LFESAFLELF VLRLAYRSNP 450
    AEGKLIFCNG VVLNRLQCVR GFGEWIDSIV DFSSNLHSMN IDISAFSCIA 500
    ALAVITERHG LKEPKRVEEL QNKIVNCLKD HVTFNNGGLN RPNYLSKLLG 550
    KLPELRTLCT QGLQRIFYLK LEDLVPPPAI IDKLFLDTLP F 591
    Length:591
    Mass (Da):65,681
    Last modified:May 1, 2007 - v1
    Checksum:iE3DD191ED465C45C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC136009 mRNA. Translation: AAI36010.1.
    RefSeqiNP_001093678.1. NM_001100208.1.
    UniGeneiStr.34862.

    Genome annotation databases

    EnsembliENSXETT00000011580; ENSXETP00000011580; ENSXETG00000031753.
    GeneIDi100101682.
    KEGGixtr:100101682.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC136009 mRNA. Translation: AAI36010.1 .
    RefSeqi NP_001093678.1. NM_001100208.1.
    UniGenei Str.34862.

    3D structure databases

    ProteinModelPortali A4IIG7.
    SMRi A4IIG7. Positions 254-591.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSXETT00000011580 ; ENSXETP00000011580 ; ENSXETG00000031753 .
    GeneIDi 100101682.
    KEGGi xtr:100101682.

    Organism-specific databases

    CTDi 4929.
    Xenbasei XB-GENE-480893. nr4a2.

    Phylogenomic databases

    GeneTreei ENSGT00740000115375.
    HOVERGENi HBG052663.
    KOi K08558.
    OMAi MWEDPGS.
    OrthoDBi EOG75XGKJ.
    TreeFami TF315430.

    Enzyme and pathway databases

    Reactomei REACT_210122. Nuclear Receptor transcription pathway.

    Gene expression databases

    Bgeei A4IIG7.

    Family and domain databases

    Gene3Di 1.10.565.10. 1 hit.
    3.30.50.10. 1 hit.
    InterProi IPR003070. Nuc_orph_rcpt.
    IPR008946. Nucl_hormone_rcpt_ligand-bd.
    IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
    IPR003073. NURR_rcpt.
    IPR001723. Str_hrmn_rcpt.
    IPR001628. Znf_hrmn_rcpt.
    IPR013088. Znf_NHR/GATA.
    [Graphical view ]
    Pfami PF00104. Hormone_recep. 1 hit.
    PF00105. zf-C4. 1 hit.
    [Graphical view ]
    PRINTSi PR01284. NUCLEARECPTR.
    PR01287. NURRNUCRCPTR.
    PR00398. STRDHORMONER.
    PR00047. STROIDFINGER.
    SMARTi SM00430. HOLI. 1 hit.
    SM00399. ZnF_C4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48508. SSF48508. 1 hit.
    PROSITEi PS00031. NUCLEAR_REC_DBD_1. 1 hit.
    PS51030. NUCLEAR_REC_DBD_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Xenopus Gene Collection (XGC) project
      Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiNR4A2_XENTR
    AccessioniPrimary (citable) accession number: A4IIG7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 18, 2008
    Last sequence update: May 1, 2007
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3