A4IID4 (PI4KB_XENTR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphatidylinositol 4-kinase beta
Short name=PI4K-beta
Short name=PI4Kbeta
Short name=PtdIns 4-kinase beta
EC=2.7.1.67

Gene names

Name:	pi4kb
Synonyms:	pik4cb

Organism

Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

Taxonomic identifier

8364 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana

Protein attributes

Sequence length	806 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP) By similarity.
Catalytic activity	ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate.
Subcellular location	Endomembrane system By similarity. Mitochondrion outer membrane; Peripheral membrane protein By similarity. Rough endoplasmic reticulum membrane; Peripheral membrane protein By similarity.
Sequence similarities	Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. Contains 1 PI3K/PI4K domain. Contains 1 PIK helical domain.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane Mitochondrion Mitochondrion outer membrane
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	phosphatidylinositol-mediated signaling Inferred from electronic annotation. Source: InterPro
Cellular component	mitochondrial outer membrane Inferred from electronic annotation. Source: UniProtKB-SubCell rough endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	1-phosphatidylinositol 4-kinase activity Inferred from electronic annotation. Source: EC ATP binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 806	806	Phosphatidylinositol 4-kinase beta		PRO_0000365171
Regions
	Domain	55 – 247	193	PIK helical
	Domain	549 – 755	207	PI3K/PI4K
	Compositional bias	107 – 110	4	Poly-Glu

Sequences

	Sequence		Length	Mass (Da)
	A4IID4 [UniParc]. Last modified May 1, 2007. Version 1. Checksum: E1323728B674D708	FASTA	806	90,709
	10 20 30 40 50 60 MGDTMVEPVP AKLSDPTLVL RGNGGSPLCV ITEGVGEAQM VIDPDVAEKA CQDVLDKVKL 70 80 90 100 110 120 IRGSSAESLD KIDGSDTGDG GSLANGDAGP RHSESCGPPV SASRITEEEE SLIDINSVKS 130 140 150 160 170 180 ARRRQKNNSA KQSWLLRLFE CKLFDVSMAI SYLYNSKEPG VQAYIGNRLF CFRYEDVDFY 190 200 210 220 230 240 LPQLLNMYIH MDEDVGDAIK PYVVHRCRQS INFSLQCAWL LGAYSSDMHI STQRHSRGTK 250 260 270 280 290 300 LRKLILSDEL KPAHKKREIP PLSLAPDTGL SPSKRTHQRS KSDATVSISL SSNLKRTSSN 310 320 330 340 350 360 PKVENDDEPV RLAPEREFIK SLMAIGKRLA TLPTKEQKTQ RLISELSLLN HKLPARVWLP 370 380 390 400 410 420 TAGFDHHVVR VPHTQAVVLN SKDKAPYLIY VEVLECENFE TSLVPVRIPE NRIRSTRSVE 430 440 450 460 470 480 NLPECGITHE QRASSFTTVP NYDNDDEAWS VDDIGELQVE LPELHTNSCD NISQFSVDSI 490 500 510 520 530 540 TSQESKDPVF IAAGDIRRRL SEQLAHTPTT FRRDPEDPSA VALKEPWQEK VRRIREGSPY 550 560 570 580 590 600 GHFPNWRLLS VIVKCGDDLR QELLAYQVLK QLQSIWESER VPLWIRPYKI LVISADSGMI 610 620 630 640 650 660 EPVVNAVSIH QVKKQSQLSL LDYFLQEHGS CTTEAFLTAQ RNFVQSCAGY CLVCYLLQVK 670 680 690 700 710 720 DRHNGNILLD AEGHIIHIDF GFILSSSPRN LGFETSAFKL TSEFVDVMGG LNGDMFNYYK 730 740 750 760 770 780 MLMLQGLIAA RKHMDRVVQI VEIMQQGSQL PCFHGSSTIR NLKERFHMNM TEEQLQVLVE 790 800 QMVDGSMRSI TTKLYDGFQY LTNGIM

References

[1]	NIH - Xenopus Gene Collection (XGC) project Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC135973 mRNA. Translation: AAI35974.1.
RefSeq	NP_001096204.1. NM_001102734.1.
UniGene	Str.2536.
3D structure databases
ProteinModelPortal	A4IID4.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	100124755.
KEGG	xtr:100124755.
Organism-specific databases
CTD	5298.
Xenbase	XB-GENE-997612. pi4kb.
Phylogenomic databases
eggNOG	veNOG07907.
HOVERGEN	HBG053597.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR000403. PI3/4_kinase_cat. IPR018936. PI3/4_kinase_CS. IPR015433. PI_Kinase. [Graphical view]
Gene3D	G3DSA:1.10.1070.11. PI3/4_kinase_cat. 1 hit.
KO	K00888.
PANTHER	PTHR10048. PI_Kinase. 1 hit.
Pfam	PF00454. PI3_PI4_kinase. 1 hit. [Graphical view]
SMART	SM00146. PI3Kc. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS00915. PI3_4_KINASE_1. 1 hit. PS00916. PI3_4_KINASE_2. 1 hit. PS50290. PI3_4_KINASE_3. 1 hit. PS51545. PIK_HELICAL. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PI4KB_XENTR

Accession

Primary (citable) accession number: A4IID4

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 3, 2009
Last sequence update:	May 1, 2007
Last modified:	November 16, 2011
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program